Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 2, February 2026.Cannabidiol and cannabigerol suppress maximal electroshock seizures. Cannabidiol and cannabigerol show similar dose–response properties. Both cannabinoids show no toxicity at effective doses. ABSTRACT Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population.
Han Zhong Zhou +3 more
wiley +1 more source
Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe [PDF]
, 2020 Zahi Abu Ghosh +3 more
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Clinical Endocrinology, Volume 104, Issue 2, Page 167-174, February 2026.ABSTRACT Objective To investigate the association between health literacy levels and biochemical control of hypothyroidism, measured by serum TSH and free thyroxine (FT4) levels, in patients receiving levothyroxine (L‐T4) therapy. Methods We conducted a cross‐sectional study at the Thyroid Disorders Outpatient Clinic, Escola Paulista de Medicina ...
Jessyka Krause Meneses +4 more
wiley +1 more source
Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim +4 more
wiley +1 more source
ATAD3 duplications bridge mitochondrial diseases and Aicardi–Goutières syndrome
Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 287-294, February 2026.ATAD3 locus duplications cause a severe neonatal mitochondrial disorder with neuroimaging features resembling interferonopathies, and suggest a mitochondrial nucleic acid‐triggered interferon response. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16446 Abstract A recurrent 68‐kb heterozygous duplication of the ATAD3 locus ...
Pauline Planté‐Bordeneuve +26 more
wiley +1 more source
Hydroxypropyl Methylcellulose Capsules Enhance Aerodynamic Performance of Carrier-Based Dry Powder Inhaler Formulations: A Comprehensive Evaluation of Capsule Material Effects. [PDF]
PharmaceuticsDumont C +8 more
europepmc +1 more source
Simulated effects of phenytoin on control and schizophrenic models.
, 2015 J. Siekmeier Peter, P David
openalex +2 more sources
Stevens-Johnson syndrome following concurrent phenytoin and holocranial radiotherapy [PDF]
, 2009 Shikha Goyal +3 more
openalex +1 more source
Antiseizure Treatments and Liver Injury: Expect (and Prevent) the Unexpected. [PDF]
Epilepsy CurrBunch M +4 more
europepmc +1 more source
Postoperative seizure prophylaxis after craniotomy: a current evidence and ongoing controversy. [PDF]
Ann Med Surg (Lond)Gould J, Patel S, Chaurasia B.
europepmc +1 more source