Results 131 to 140 of about 46,241 (267)
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 6, November 2026.ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source
Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay +3 more
wiley +1 more source
Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy
Advanced Science, Volume 13, Issue 57, 14 October 2026.A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan +9 more
wiley +1 more source
Comparison of topical application of Mummify and Phenytoin cream on skin wound healing in rat
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2003 Background and Objective: Mummify is a semisolid material, which comes out from fissures of caves and contains hydrocarbons, oxygen, nitrogen and sulfur. This material has a specific position among people of Jiroft town as a healing agent of skin wounds.
M Allah Tavakoli +2 more
doaj
A murine model of amyloid‐enhanced tauopathy: Comparison of wild‐type and P301L‐tau
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION To optimize a model of amyloid‐enhanced tauopathy we compared wild‐type (WT) tau with P301L‐tau in a mouse with mature amyloid. METHODS Mice transgenic for amyloid precursor protein and presenilin‐1 (APP+PS1, A/P) were injected intravenously with adeno‐associated virus with capsid B10 (AAV.CAP‐B10) expressing either WT or P301L ...
Dylan J. Finneran +4 more
wiley +1 more source
A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract BACKGROUND Our prior work demonstrated systemic P301L‐tau injections in mice with mature amyloid resulted in several‐fold enhancement of tauopathy compared to non‐transgenic (NTg) littermates. METHODS APP+PS1 mice were injected intravenously with AAV.CAP‐B10 expressing P301L tau (A/P+P301L).
Dylan J. Finneran +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson +8 more
wiley +1 more source
Cenobamate use in super‐refractory status epilepticus: A report of three cases
Epileptic Disorders, Volume 28, Issue 5, Page 1661-1668, October 2026.Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi +11 more
wiley +1 more source
Exploring the efficacy and safety of perampanel in epilepsia partialis continua: A case series
Epileptic Disorders, Volume 28, Issue 5, Page 1669-1674, October 2026.Abstract Background Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus (SE), which is commonly drug‐resistant requiring treatment with multiple antiseizure medications (ASM). There are no established guidelines for pharmacological management.
Setareh Lahsaee +3 more
wiley +1 more source