Results 11 to 20 of about 65,177 (296)

Phenytoin toxicity

BMJ Case Reports, 2022
© BMJ Publishing Group Limited 2022. No commercial reuse. See rights and permissions. Published by BMJ. DESCRIPTION A teenage girl, who had been treated with phenytoin sodium for seizure disorder since she was 4 years old, presented with failure to gain ...
Avivar Awasthi, Neeti Agrawal, Partha Pratim Chakraborty, Animesh Maiti   +3 more
openaire   +3 more sources

Nose to Brain Delivery of Phenytoin Sodium Loaded Nano Lipid Carriers: Formulation, Drug Release, Permeation and In Vivo Pharmacokinetic Studies

Pharmaceutics, 2021
An acute epileptic seizure is a seizure emergency fatal condition that requires immediate medical attention. IV phenytoin sodium remains the second line therapeutic agent for the immediate treatment of status epilepticus.
Sreeja C. Nair, Kollencheri Puthenveettil Vinayan, Sabitha Mangalathillam   +2 more
doaj   +2 more sources

CYP2C9 polymorphisms are associated with phenytoin toxicity in South-Indian epileptic patients

Journal of Dr. NTR University of Health Sciences, 2020
Background and Aims: The contribution of CYP2C9 in phenytoin metabolism is generally modest, but it increases with increasing serum phenytoin concentration.
Rakesh Reddy Reddigari, S V Naveen Prasad, Vengamma Bhuma, P VGK Sarma, Appa Rao Anumolu   +4 more
doaj   +2 more sources

Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series

Pharmaceuticals, 2018
BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic ...
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +2 more sources

Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

Neurotherapeutics, 2015
Mutations in SCN8A are associated with epilepsy and intellectual disability. SCN8A encodes for sodium channel Nav1.6, which is located in the brain.
Dick Lindhout, Carolien G De Kovel, Bobby P C Koeleman   +2 more
exaly   +2 more sources

Phenytoin-induced Ogilvie syndrome: A rare case report [PDF]

SAGE Open Medical Case Reports
Phenytoin is a widely prescribed antiepileptic drug that is associated with various adverse effects, but gastrointestinal manifestations are rare. Therapeutic drug monitoring is essential for ensuring safe and effective dosing by measuring the drug ...
Joel Sabu, Kevin Jose Madapat, Namitha K. Baby   +2 more
doaj   +2 more sources

Therapeutic potential for phenytoin: targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer

Breast Cancer Research and Treatment, 2012
Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits.
Ming Yang, Jeffrey D Calhoun, Lori L Isom   +2 more
exaly   +2 more sources

Phenytoin: A Guide to Therapeutic Drug Monitoring

Proceedings of Singapore Healthcare, 2013
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons), Wai Hing Lim B.Pharm (Hons), M Clin Pharm   +1 more
doaj   +2 more sources

Hepatoprotective potential of N-acetyl cysteine in rats with phenytoin induced liver injury [version 1; peer review: 2 approved] [PDF]

F1000Research
Background Phenytoin is an anticonvulsant medication that is effective in treating various seizure disorders. It is mostly metabolized by the liver, which increases the risk of PHT-induced hepatotoxicity. Aims This study aimed to assess the effectiveness
Fadhaa Abdulameer Ghafil, Sahar A. Majeed, Zahraa Abed Al-kareem, Amal Umran Mosa, Deema Diyaa Azeez, Noor D. Aziz   +5 more
doaj   +2 more sources

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin [PDF]

AAPS Journal, 2013
Po‐Chang Chiang, Harvey Wong
openalex   +2 more sources