Results 11 to 20 of about 93,963 (358)

Nose to Brain Delivery of Phenytoin Sodium Loaded Nano Lipid Carriers: Formulation, Drug Release, Permeation and In Vivo Pharmacokinetic Studies

Pharmaceutics, 2021
An acute epileptic seizure is a seizure emergency fatal condition that requires immediate medical attention. IV phenytoin sodium remains the second line therapeutic agent for the immediate treatment of status epilepticus.
Sreeja C. Nair, Kollencheri Puthenveettil Vinayan, Sabitha Mangalathillam   +2 more
doaj   +2 more sources

Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup [PDF]

American Journal of Kidney Diseases, 2016
The Extracorporeal Treatments in Poisoning (EXTRIP) Workgroup conducted a systematic literature review using a standardized process to develop evidence-based recommendations on the use of extracorporeal treatment (ECTR) in patients with phenytoin ...
Anseeuw, Kurt, Burdmann, Emmanuel A., Ghannoum, Marc, Gosselin, Sophie, Hoffman, Robert S., Lavergne, Valery, Mowry, James B., Nolin, Thomas D.   +7 more
core   +2 more sources

Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series

Pharmaceuticals, 2018
BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic ...
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +2 more sources

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B Genotype and Phenytoin Dosing [PDF]

Clinical pharmacology and therapy, 2014
Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large inter-patient variability partly due to genetic variations in CYP2C9.
Callaghan, J. Thomas, Caudle, Kelly E., Klein, Teri E., Lee, Ming Ta Michael, Mintzer, Scott E., Rettie, Allan E., Smith, Lisa H., Whirl-Carrillo, Michelle   +7 more
core   +4 more sources

Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

Neurotherapeutics, 2015
Mutations in SCN8A are associated with epilepsy and intellectual disability. SCN8A encodes for sodium channel Nav1.6, which is located in the brain.
Dick Lindhout, Carolien G De Kovel, Bobby P C Koeleman   +2 more
exaly   +2 more sources

Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations

BMC Medical Informatics and Decision Making, 2012
Background Therapeutic drug monitoring of phenytoin by measurement of plasma concentrations is often employed to optimize clinical efficacy while avoiding adverse effects.
Krasowski Matthew D, Penrod Louis E
doaj   +2 more sources

Phenytoin-induced Ogilvie syndrome: A rare case report [PDF]

SAGE Open Medical Case Reports
Phenytoin is a widely prescribed antiepileptic drug that is associated with various adverse effects, but gastrointestinal manifestations are rare. Therapeutic drug monitoring is essential for ensuring safe and effective dosing by measuring the drug ...
Joel Sabu, Kevin Jose Madapat, Namitha K. Baby   +2 more
doaj   +2 more sources

Therapeutic potential for phenytoin: targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer

Breast Cancer Research and Treatment, 2012
Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits.
Ming Yang, Jeffrey D Calhoun, Lori L Isom   +2 more
exaly   +2 more sources

Phenytoin: A Guide to Therapeutic Drug Monitoring

Proceedings of Singapore Healthcare, 2013
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons), Wai Hing Lim B.Pharm (Hons), M Clin Pharm   +1 more
doaj   +2 more sources

Hepatoprotective potential of N-acetyl cysteine in rats with phenytoin induced liver injury [version 1; peer review: 2 approved] [PDF]

F1000Research
Background Phenytoin is an anticonvulsant medication that is effective in treating various seizure disorders. It is mostly metabolized by the liver, which increases the risk of PHT-induced hepatotoxicity. Aims This study aimed to assess the effectiveness
Fadhaa Abdulameer Ghafil, Sahar A. Majeed, Zahraa Abed Al-kareem, Amal Umran Mosa, Deema Diyaa Azeez, Noor D. Aziz   +5 more
doaj   +2 more sources