Results 21 to 30 of about 92,765 (376)

Effect of Topical Phenytoin in Treatment of Corneal Epithelial Defect in Rabbits [PDF]

Trends in Pharmaceutical Sciences, 2018
Re-epithelialization of corneal epithelium is a major problem in delayed corneal wound healing. Phenytoin has been used topically for different type of cutaneous wounds and ulcers.
Masoomeh Eghtedari, Vahid Beigi, Mohammad Reza Soltani   +2 more
doaj   +3 more sources

The role of heat-not-burn, snus and other nicotine-containing products as interventions for epileptic patients who take phenytoin and smoke cigarettes

Toxicology Reports, 2022
Background: Cigarette smoke increases the metabolism of phenytoin, a widely used anti-epileptic agent, by inducing cytochrome P450 enzymes in the liver. Therefore, cigarette smoke may reduce the clinical effect of phenytoin.
P.N. Valodia
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA‐B Genotypes and Phenytoin Dosing: 2020 Update

Clinical pharmacology and therapy, 2020
Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9.
J. Karnes, A. Rettie, A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, A. Llerena, Michelle Whirl‐Carrillo, T. Klein, E. Phillips, S. Mintzer, A. Gaedigk, K. Caudle, J. Callaghan   +14 more
semanticscholar   +1 more source

Does long‐term phenytoin have a place in Dravet syndrome?

Annals of Clinical and Translational Neurology, 2022
Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent ...
George A. Zographos, Sophie J. Russ‐Hall, Ingrid E. Scheffer   +2 more
doaj   +1 more source

Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations

BMC Medical Informatics and Decision Making, 2012
Background Therapeutic drug monitoring of phenytoin by measurement of plasma concentrations is often employed to optimize clinical efficacy while avoiding adverse effects.
Krasowski Matthew D, Penrod Louis E
doaj   +1 more source

Restoration of Germinal Epithelium with Usage of Antioxidant Oils in Phenytoin Induced Testicular Toxicity: A Comparative Study in Rats

Journal of Bahria University Medical and Dental College, 2023
Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn Oil (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design and setting: An Experimental Longitudinal study was done at AL-Tibri Medical College
Khalique-ur- Rehman, Syed Muhammad Masood Ali, Khalid Shehzad, Sonia Khan, Sarah Sughra, Hina Khan   +5 more
doaj   +1 more source

Sertraline and Phenytoin Drug Interaction in a Geriatric Patient [PDF]

, 2017
This report presents the case of a 78-year-old man residing in a nursing home who presented with a 2-month history of increasing lethargy and confusion. These symptoms coincided with the initiation of sertraline in the patient.
Caprio, Thomas V., DiLoreto, Stefanie E., Hopkins, Heather A., Nathan, Kobi T, Ta, Nhon A.   +4 more
core   +2 more sources

Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

Trials, 2022
Background Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side effects.
David J. Kopsky, Ruben P. A. van Eijk, Janna K. Warendorf, Jan M. Keppel Hesselink, Nicolette C. Notermans, Alexander F. J. E. Vrancken   +5 more
doaj   +1 more source

Anticonvulsant Effect of Nebivolol alone and in Combination with Phenytoin against Maximal Electroshock-Induced Seizures in Mice [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Phenytoin is widely used in treatment of generalised tonic clonic seizures but its adverse effects make its usage limited. Hence forth, there is a need for newer antiepileptics. Studies have shown antiepileptic property for nebivolol in
Anuranjani Dhamodharan, Nitya Selvaraj, R Meenakshi   +2 more
doaj   +1 more source

Plasma arginine vasopressin concentrations in epileptics under monotherapy [PDF]

, 1983
Plasma arginine vasopressin concentrations were determined by radio-immunoassay in 112 adult epileptics who were taking carbamazepine, phenytoin, primidone, or sodium valproate in long-term monotherapy, and in 19 controls.
E Perucca, E Perucca, K. -H. Krause, M Heim, MG Ashton, MP Fichman, NJ Smith, P Sordillo, P. Berlit, RL Marsland, T Kimura, TH Thomas, W Rascher, W. Rascher, WP Stephens, WP Stephens   +15 more
core   +1 more source