Results 21 to 30 of about 65,177 (296)

Properties of human brain sodium channel α‐subunits expressed inHEK293cells and their modulation by carbamazepine, phenytoin and lamotrigine [PDF]

British Journal of Pharmacology, 2013
Xin Qiao, Guangchun Sun, Jeffrey J. Clare, Taco R. Werkman, Wytse J. Wadman   +4 more
openalex   +2 more sources

Comparing the predictability of serum phenytoin concentrations between Bayesian method and mass-balance algorithm

Journal of Health Science and Medical Research (JHSMR), 2007
Objective: To compare the predictability of the two methods, Bayesian method (non steady-state assumption) and massbalance algorithm (steady-state assumption), used for predicting serum phenytoin concentrations.
W Wongpoowarak, C Rattanajamitr, P Wongpoowarak, N Somsak   +3 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing

Clinical Pharmacology and Therapeutics, 2014
K. Caudle, A. Rettie, Michelle Whirl‐Carrillo, L. H. Smith, Scott E. Mintzer, Ming Ta Michael Lee, Ming Ta Michael Lee, Teri E. Klein, J. T. Callaghan   +8 more
exaly   +2 more sources

Phenytoin induced Chorea: commonly used antiepileptic drug causing a rare movement disorder [PDF]

Asia Pacific Journal of Medical Toxicology, 2020
Background: Phenytoin, a commonly prescribed antiepileptic drug, causes side effects like ataxia, tremor, hirsutism, gum hyperplasia, insomnia, confusion, headache and vertigo when used for longer duration.
Rambhupal NAGIREDDY, Deepika Joshi, Sooraj Patil, Anand Kumar   +3 more
doaj   +1 more source

Phenytoin as seizure prophylaxis in hematopoietic stem cell transplantation with busulfan conditioning

Frontiers in Neurology, 2022
BackgroundPhenytoin is widely used as primary seizure prophylaxis in hematopoietic stem cell transplantation in patients undergoing myeloablative conditioning with busulfan. Because of the negative side effects of phenytoin, we abandoned phenytoin use in
R. S. Germeraad, A. M. P. Demandt, R. P. W. Rouhl, R. P. W. Rouhl, R. P. W. Rouhl   +4 more
doaj   +1 more source

Effect of Topical Phenytoin in Treatment of Corneal Epithelial Defect in Rabbits [PDF]

Trends in Pharmaceutical Sciences, 2018
Re-epithelialization of corneal epithelium is a major problem in delayed corneal wound healing. Phenytoin has been used topically for different type of cutaneous wounds and ulcers.
Masoomeh Eghtedari, Vahid Beigi, Mohammad Reza Soltani   +2 more
doaj   +3 more sources

The role of heat-not-burn, snus and other nicotine-containing products as interventions for epileptic patients who take phenytoin and smoke cigarettes

Toxicology Reports, 2022
Background: Cigarette smoke increases the metabolism of phenytoin, a widely used anti-epileptic agent, by inducing cytochrome P450 enzymes in the liver. Therefore, cigarette smoke may reduce the clinical effect of phenytoin.
P.N. Valodia
doaj   +1 more source

Carbamazepine and phenytoin induced Stevens‐Johnson syndrome is associated with HLA‐B*1502 allele in Thai population

Epilepsia, 2008
Vorasuk Shotelersuk
exaly   +2 more sources

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA‐B Genotypes and Phenytoin Dosing: 2020 Update

Clinical pharmacology and therapy, 2020
Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9.
J. Karnes, A. Rettie, A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, A. Llerena, Michelle Whirl‐Carrillo, T. Klein, E. Phillips, S. Mintzer, A. Gaedigk, K. Caudle, J. Callaghan   +14 more
semanticscholar   +1 more source

Does long‐term phenytoin have a place in Dravet syndrome?

Annals of Clinical and Translational Neurology, 2022
Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent ...
George A. Zographos, Sophie J. Russ‐Hall, Ingrid E. Scheffer   +2 more
doaj   +1 more source