Results 61 to 70 of about 10,045 (177)

Prospective Open‐Label Safety Study of Edaravone Dexborneol in Filipino Patients With Acute Ischemic Stroke

Brain and Behavior, Volume 16, Issue 3, March 2026.
This prospective, single‐arm study evaluated the real‐world safety of edaravone dexborneol in Filipino patients with acute ischemic stroke treated within 48 h of symptom onset. Adverse events were predominantly mild and transient, with headache and reversible liver enzyme elevations being the most common. No treatment discontinuations, life‐threatening
Zenyros Faith Sabellano, Bonifacio Pedregosa II, Laurence Kristoffer Batino, Jose Navarro   +3 more
wiley   +1 more source

Ataxia and Seizures despite Phenytoin: A Case Report Highlighting the Importance of TDM and Genetic Influences

Case Reports in Neurological Medicine
Adverse drug reactions to commonly prescribed medications such as phenytoin, used for seizures, often go undetected due to various factors. This case report highlights a 52-year-old male diagnosed with late-onset epilepsy who was prescribed phenytoin ...
Rachel Manoj, Arpita Meher, Jefry Winner G.   +2 more
doaj   +1 more source

Amitriptyline Induced Life‐Threatening Steven–Johnson Syndrome: Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Stevens–Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine, and carbamazepine are commonly implicated.
Wondwosen Mengist Dereje, Lidya Yalew, Nardos Tafesse, Teklegiorgis Goshime Getachew   +3 more
wiley   +1 more source

Nanoemulsions for Skin Delivery of Essential Oils: A Systematic Review

Phytotherapy Research, Volume 40, Issue 3, Page 847-872, March 2026.
ABSTRACT Essential oils (EOs) are recognized for their multiple health benefits. However, their high volatility, low stability, and limited water solubility limit their effective application. This systematic review aims to assess the use of nanoemulsions as delivery systems for the topical administration of EOs, highlighting their efficacy, safety, and
Thais Leticia Moreira da Silva, Anna Claudia Morais de Oliveira Capote, Flávio Luís Beltrame, Priscileila Colerato Ferrari   +3 more
wiley   +1 more source

Personalized care of paediatric drug‐resistant epilepsy in Africa: A single‐centre pilot study utilizing mobile health and genetic testing

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 394-406, March 2026.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.70075 This original article is commented on by Mante on pages 307–308 of this issue. Abstract Aim To evaluate personalized care or precision medicine initiatives, including mobile health (mHealth) technology and genetic screening, in a South African paediatric epilepsy clinic ...
Ian S. Olivier, Karen Fieggen, Sandra Komarzynski, Elin H. Davies, Irene Muchada, Caitlin McIntosh, Alina Esterhuizen, Richard J. Burman, Jo M. Wilmshurst, and the University of Cape Town (UCT) Human Genetics Precision Medicine Epilepsy Group, Nicholas Loxton, Shrinav R Dawlatt, Akshay Vanmali   +12 more
wiley   +1 more source

Practice parameters in management of status epileptics

Annals of Indian Academy of Neurology, 2014
Status epilepticus (SE) is an emergency neurological problem, more common in the developing countries due to high incidence of infection, stroke and head injury.
Usha Kant Misra, Jayantee Kalita, Sanjeev Kumar Bhoi   +2 more
doaj   +1 more source

Development of UPLC–MS/MS method for the simultaneous quantification of valproic acid and phenytoin in human plasma and application to study pharmacokinetic interaction in epilepsy patients

Heliyon
Valproic acid and phenytoin are two prevalent antiepileptic medications known for their narrow indices and propensity for cardiovascular and respiratory system toxicity.
Sil Thanh Nguyen, Duy Nguyen Ho, Thi Anh Huynh Huynh, Huyen Thu Thi Nguyen, Ngan Kim Thi Ly, Minh Van Le, Tho Vinh Minh Chau Do   +6 more
doaj   +1 more source

RLIP76, a non-ABC transporter, and drug resistance in epilepsy

BMC Neuroscience, 2005
Background Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intracerebral accumulation.
Awasthi Yogesh C, Cucullo Luca, Singhal Sharad S, Fazio Vince, Hallene Kerri L, Awasthi Sanjay, Dini Gabriele, Janigro Damir   +7 more
doaj   +1 more source

Case report and literature review: management of Paxlovid (nirmatrelvir/ritonavir)-induced acute tacrolimus toxicity in a patient with systemic lupus erythematosus

Frontiers in Pharmacology
Despite the availability of effective vaccines and treatments for SARS-CoV-2, managing COVID-19 in patients with systemic lupus erythematosus (SLE) remains challenging, particularly considering drug-drug interactions (DDIs).
Chenxiao Jiang, Xiaodi Yan, Peng Xia, Xuemei Luo, Haoyue Zheng, Hanwen Tong, Yun Liu, Huaijun Zhu, Peng Xu, Jun Wang   +9 more
doaj   +1 more source

Development and Validation of an LC-MS/MS Method and Comparison with a GC-MS Method to Measure Phenytoin in Human Brain Dialysate, Blood, and Saliva

Journal of Analytical Methods in Chemistry, 2018
Phenytoin (PHT) is one of the most often used critical dose drugs, where insufficient or excessive dosing can have severe consequences such as seizures or toxicity.
Raphael Hösli, Stefan König, Stefan F. Mühlebach   +2 more
doaj   +1 more source