Results 51 to 60 of about 621,544 (210)
Epilepsia, EarlyView.Abstract Objective To describe treatment decisions after first anti‐seizure medication (ASM) failure in focal epilepsy and describe how they have changed across two trial eras, and whether observed prescribing matched clinicians stated preferences. Methods We analyzed the focal epilepsy cohorts from two UK pragmatic, randomized trials, Standard and New
Isaac J. Egesa +4 more
wiley +1 more source
Phenytoin toxicity presenting as acute meningo-encephalitis in children
, 2012 Phenytoin can produce significant dose-related toxicity because of its zero order pharmacokinetics and is an important issue in pediatric emergency medicine.
Yadav, Anita +2 more
core +1 more source
Phenytoin and Rifampin Do Not Decrease Levels in Acute Tacrolimus Toxicity
Journal of Investigative Medicine High Impact Case Reports, 2018 Tacrolimus is used in bone marrow transplant patients to prevent graft-versus-host disease. There have been few case reports of tacrolimus toxicity (>30 ng/mL) in solid organ recipients as well as in nontransplant patients.
Benjamin O. Lawson MD +2 more
doaj +1 more source
Causes of Antiepileptic Treatment Failure
Pediatric Neurology Briefs, 1987 The Veterans Administration Epilepsy Cooperative Study Group (Regional Epilepsy Center, VA Med Cntr, 4500 S Lancaster Rd, Dallas, TX) have evaluated monotherapy with carbamazepine, phenobarbital, phenytoin, and primidone in a total of 622 patients with ...
J Gordon Millichap
doaj +1 more source
Imaging in phenytoin induced neurotoxicity: a case series [PDF]
, 2017 Phenytoin is a commonly used anti-epileptic drug for various types of seizure disorders except for absent seizures. Long term dose dependant neurological side effects of phenytoin therapy include cerebellar atrophy, cerebral atrophy and brain stem ...
Thakker, Vishal +7 more
core +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar +4 more
wiley +1 more source
Therapeutic Drug Monitoring of Antiepileptic Drugs
Journal of Nepal Medical Association, 2008 Commonly used conventional antiepileptic drugs for pharmacotherapy in epilepsy are phenytoin, carbamazepine and valproic acid. These drugs have complex pharmacokinetic properties leading to fluctuation in their plasma level at given same therapeutic dose.
Geeta Shakya +3 more
doaj +1 more source
Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy
Case Reports in Oncological Medicine, 2013 Case reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme,
Shereen Elazzazy +3 more
doaj +1 more source
Phenytoin toxicity: A cause of reversible monoplegia
Cleveland Clinic Journal of Medicine, 1987 Phenytoin sodium (Dilantin), a frequently used anticonvulsant, has many well-recognized side effects. Of these, neurological ones are prominent and, when present, usually consist of ataxia, nystagmus, or dysarthria. Phenytoin toxicity in patients with previous strokes may present as a “re-stroke” syndrome.
M H, Abdulhadi +3 more
openaire +2 more sources