Results 61 to 70 of about 10,598 (216)
Epilepsia Open, EarlyView.Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini +9 more
wiley +1 more source
Phenytoin-induced toxicity in the postnatal cerebellar development in rat: effect of calotropis procera on selective biochemical and haematological variables [PDF]
, 2011 Phenytoin, an antiepileptic drug is used in managing seizures. Phenytoin-associated oxidative stress causes cellular damage by the generation of free radicals.
IO Imosemi +7 more
core +2 more sources
Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy
Case Reports in Oncological Medicine, 2013 Case reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme,
Shereen Elazzazy +3 more
doaj +1 more source
Phenytoin toxicity: A cause of reversible monoplegia
Cleveland Clinic Journal of Medicine, 1987 Phenytoin sodium (Dilantin), a frequently used anticonvulsant, has many well-recognized side effects. Of these, neurological ones are prominent and, when present, usually consist of ataxia, nystagmus, or dysarthria. Phenytoin toxicity in patients with previous strokes may present as a “re-stroke” syndrome.
M H, Abdulhadi +3 more
openaire +2 more sources
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]
, 2011 Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen +3 more
core +1 more source
Imaging in phenytoin induced neurotoxicity: a case series [PDF]
, 2017 Phenytoin is a commonly used anti-epileptic drug for various types of seizure disorders except for absent seizures. Long term dose dependant neurological side effects of phenytoin therapy include cerebellar atrophy, cerebral atrophy and brain stem ...
Thakker, Vishal +7 more
core +2 more sources
Epilepsia Open, EarlyView.Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi +6 more
wiley +1 more source
DRUG INTERACTION INDUCED PHENYTOIN TOXICITY: A CASE REPORT [PDF]
, 2014 Phenytoin is a narrow therapeutic indexed antiepileptic drug. Many drugs competitively inhibit isoenzymes responsible for its metabolism when concurrently administered and increases the phenytoin plasma concentration leading to serious adverse effects ...
B.S, KESHAVA +4 more
core +1 more source
Journal of Medical Case Reports, 2012 Introduction Carnitine is an essential cofactor in mitochondrial fatty acid oxidation. Carnitine deficiency results in accumulation of non-oxidized fatty acyl-coenzyme A molecules, and this inhibits intra-mitochondrial degradation of ammonia ...
Ling Peter +3 more
doaj +1 more source