Results 41 to 50 of about 10,124 (185)
Molecules, 2022 Ranolazine, an antianginal and antiarrhythmic drug blocking slow inactivating persistent sodium currents, is described as a compound with anticonvulsant potential.
Kinga Borowicz-Reutt, Monika Banach
doaj +1 more source
Current Medical IssuesBackground: Phenytoin is a widely used, cost-effective anticonvulsant with a narrow therapeutic range, requiring close monitoring to avoid toxicity. Our aim was to investigate phenytoin toxicity in an emergency department setting, focusing on clinical ...
Nejah F. Ellouze +4 more
doaj +1 more source
Cerebellar Atrophy with Phenytoin and Epilepsy
Pediatric Neurology Briefs, 1994 Cerebellar size measured by MRI was studied in a group of 36 adults (21 to 54 years, mean age 34 years) with intractable partial epilepsy treated with phenytoin longer than 4 years at the Epilepsy Center of the Long Island Jewish Medical Center, New Hyde
J Gordon Millichap
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Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning
Global Journal of Transfusion MedicinePhenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy challenging. Because of its high protein binding property, the usual hemodialysis and hemoperfusion are not usually ...
Purshotam Paudel +3 more
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Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale +5 more
wiley +1 more source
Phenytoin Toxicity: A Case Report [PDF]
Journal of Young Pharmacists, 2015 Background: Phenytoin is a commonly used sedative antiepileptic medication in many countries. It is used against tonic-clonic and complex partial seizures. Phenytoin is reported to cause a range of deleterious and erratic side effects at therapeutic and toxic doses.
Vineetha Bharathan Menon +4 more
openaire +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang +7 more
wiley +1 more source