Results 21 to 30 of about 178 (146)
Acute Phenytoin Intoxication: Causes, Symptoms, Misdiagnoses, and Outcomes
Kaohsiung Journal of Medical Sciences, 2004 Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an important issue in emergency medicine.
Wen-Juh Hwang, Jing-Jane Tsai
doaj +1 more source
N-octyl-modified magnetite NPs for optimization of solid phase extraction for trace analysis of phenytoin in real samples [PDF]
Nanomedicine Research Journal, 2019 objective: Phenytoin is an anti-seizure medication used to treat epilepsy, as well as to control arrhythmias (irregular heartbeat) and to treat migraine headaches and nerve pain.
Shaghayegh Raeisi +3 more
doaj +1 more source
Phenytoin-Induced Toxic Epidermal Necrolysis
Cureus, 2023 Toxic epidermal necrolysis (TEN) is a rare fatal mucocutaneous blistering disorder that can have varied underlying triggers. The percentage of body surface area (BSA) that is impacted by erosive blistering is what separates it from Steven Johnson syndrome (SJS), both of which have the same underlying pathogenesis and are thought to exist on a continuum
Tunuguntla, Mounika Nagarani +4 more
openaire +2 more sources
Phenytoin: A Guide to Therapeutic Drug Monitoring
Proceedings of Singapore Healthcare, 2013 Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons) +1 more
doaj +1 more source
Antiepileptic drug-induced acute psychotic disorder in a nonepileptic patient: A definite prophecy
Apollo Medicine, 2019 Psychosis induced by antiepileptic drugs (AEDs) is considerably an iatrogenic adverse drug reaction. Various mechanisms operant in the development of iatrogenic psychiatric manifestations are proposed which necessitates analyzing complaints of ...
Mohit Dahiya +3 more
doaj +1 more source
Current Medical IssuesBackground: Phenytoin is a widely used, cost-effective anticonvulsant with a narrow therapeutic range, requiring close monitoring to avoid toxicity. Our aim was to investigate phenytoin toxicity in an emergency department setting, focusing on clinical ...
Nejah F. Ellouze +4 more
doaj +1 more source
Cerebellar Atrophy with Phenytoin and Epilepsy
Pediatric Neurology Briefs, 1994 Cerebellar size measured by MRI was studied in a group of 36 adults (21 to 54 years, mean age 34 years) with intractable partial epilepsy treated with phenytoin longer than 4 years at the Epilepsy Center of the Long Island Jewish Medical Center, New Hyde
J Gordon Millichap
doaj +1 more source
Molecules, 2022 Ranolazine, an antianginal and antiarrhythmic drug blocking slow inactivating persistent sodium currents, is described as a compound with anticonvulsant potential.
Kinga Borowicz-Reutt, Monika Banach
doaj +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning
Global Journal of Transfusion MedicinePhenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy challenging. Because of its high protein binding property, the usual hemodialysis and hemoperfusion are not usually ...
Purshotam Paudel +3 more
doaj +1 more source