Results 21 to 30 of about 10,598 (216)

CYP2C9 polymorphisms are associated with phenytoin toxicity in South-Indian epileptic patients

Journal of Dr. NTR University of Health Sciences, 2020
Background and Aims: The contribution of CYP2C9 in phenytoin metabolism is generally modest, but it increases with increasing serum phenytoin concentration.
Rakesh Reddy Reddigari, S V Naveen Prasad, Vengamma Bhuma, P VGK Sarma, Appa Rao Anumolu   +4 more
doaj   +1 more source

Tacrolimus Induced Organ Failure: Reversal by Activation of the Cytochrome P450-3a System

Uro, 2021
Tacrolimus is the cornerstone component of all immunosuppressive regimens. Despite its long record of use, very little is known about its acute toxicity syndrome.
Dai D. Nghiem
doaj   +1 more source

Contributions to an improved phenytoin monitoring and dosing in hospitalized patients [PDF]

, 2016
Phenytoin (PHT) is one of the mostly used and well established anticonvulsants for the treatment of epilepsy and a standard in the antiepileptic prophylaxis in adults with severe traumatic brain injuries before and after neurosurgical intervention. Its
Tobler-Giger, Andrea
core   +1 more source

Usual erratic phenomenon, dramatic outcome: a case report of phenytoin toxicity

Psychiatry and Clinical Psychopharmacology, 2021
Phenytoin is still one of the most commonly used antiepileptic drugs in clinical practice in many countries. It has a range of usual deleterious and erratic side effects, which have been reported previously including horizontal nystagmus, ataxia and ...
Madhusudan Singh Solanki, Kuldip Kumar
doaj   +1 more source

Phenytoin toxicity presenting as acute meningo-encephalitis in children [PDF]

, 2011
Phenytoin can produce significant dose-related toxicity because of its zero order pharmacokinetics and is an important issue in pediatric emergency medicine.
Yadav, Anita, Yadav, Tribhuvan P., Gupta, Vijay, Vijay Gupta, TribhuvanP Yadav, Anita Yadav   +5 more
core   +1 more source

Death Due to Phenytoin Poisoning in an Intellectually Disabled Female Child: A Case Report

National Board of Examinations Journal of Medical Sciences, 2023
Phenytoin is a commonly used anticonvulsant, but its narrow therapeutic window can lead to toxicity, often due to medication errors or, in some cases, due to intentional overdose.
S.M. Krishna Sagar, Rakesh Miriyala, Sravani Yandava, T Mohit Kumar Moses, Narasimhulu Kuna, Kattamreddy Ananth Rupesh   +5 more
doaj   +1 more source

Phenytoin toxicity with mandibular tremor secondary to intravenous administration [PDF]

, 2002
The parenteral form or phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbumin-emia and phenytoin intoxicity following I day ...

core   +3 more sources

Paxlovid with Caution: Novel Case of Paxlovid-Induced Tacrolimus Toxicity in a Cardiac Transplant Patients

European Journal of Case Reports in Internal Medicine, 2022
Tacrolimus is commonly used as a prophylactic against acute rejection in transplant patients. Tacrolimus toxicity has numerous presentations that have been well documented in the literature and can be induced by a wide variety of agents.
Aaisha Shah, Adeel Nasrullah, Muhammad Ali Butt, Meilin Young   +3 more
doaj   +1 more source

Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

Future Journal of Pharmaceutical Sciences, 2022
Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced ...
Vivek Kumar Garg, Supriya, Ritu Shree, Ajay Prakash, Aastha Takkar, Madhu Khullar, Biman Saikia, Bikash Medhi, Manish Modi   +8 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source