Treatment of Acute Tacrolimus Toxicity with Phenytoin in Solid Organ Transplant Recipients [PDF]
Case Reports in Transplantation, 2013 The pharmacokinetics of tacrolimus are influenced by many factors, including genetic variability, acute infections, liver dysfunction, and interacting medications, which can result in elevated concentrations.
Arin S. Jantz +5 more
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Phenytoin: A Guide to Therapeutic Drug Monitoring [PDF]
Proceedings of Singapore Healthcare, 2013 Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons) +1 more
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Acute Phenytoin Intoxication: Causes, Symptoms, Misdiagnoses, and Outcomes [PDF]
Kaohsiung Journal of Medical Sciences, 2004 Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an important issue in emergency medicine.
Wen-Juh Hwang, Jing-Jane Tsai
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Phenytoin and Rifampin Do Not Decrease Levels in Acute Tacrolimus Toxicity [PDF]
Journal of Investigative Medicine High Impact Case Reports, 2018 Tacrolimus is used in bone marrow transplant patients to prevent graft-versus-host disease. There have been few case reports of tacrolimus toxicity (>30 ng/mL) in solid organ recipients as well as in nontransplant patients.
Benjamin O. Lawson MD +2 more
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Investigation on the phenytoin sodium channel-blocker effect in PDT of MDA MB 231 breast cancer using a positively charged PS [PDF]
Scientific ReportsCancer therapy, due to the rising number of detected and reported cases, is one of the most important goals of scientists worldwide. Among these, there is a strong interest in using effective noninvasive protocols for cancer therapy.
HomaSadat Esfahani +2 more
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A Clinically Relevant Drug Interaction Between Busulfan and Rifampin in the Setting of Hematopoietic Stem Cell Transplant Conditioning [PDF]
Pharmacology Research & PerspectivesBusulfan is an alkylating agent used in combination with other chemotherapeutic agents and has become a common component of conditioning regimens prior to hematopoietic stem cell transplantation. Busulfan has a very narrow therapeutic index corresponding
Colleen Drangines +2 more
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Cardiac Collapse Secondary to Phenytoin Toxicity in a Neonate Treated with Extracorporeal Membrane Oxygenation Support (ECMO). [PDF]
J Med Toxicol, 2020 Introduction: Although medication toxicity is uncommon in neonates, there are several medications used in this population that pose a risk. Phenytoin has an increased risk of toxicity given its narrow therapeutic window and variations in drug elimination.
Knecht M +5 more
europepmc +2 more sources
Journal of Integrative Medicine and Research, 2023 The zero-order pharmacokinetics of phenytoin makes it a serious problem in pediatric emergency care since it can cause considerable dose-related toxicity.
Jenith Vijayalakshmi +4 more
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Phenytoin induced Chorea: commonly used antiepileptic drug causing a rare movement disorder [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Background: Phenytoin, a commonly prescribed antiepileptic drug, causes side effects like ataxia, tremor, hirsutism, gum hyperplasia, insomnia, confusion, headache and vertigo when used for longer duration.
Rambhupal NAGIREDDY +3 more
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Journal of Bahria University Medical and Dental College, 2023 Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn Oil (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design and setting: An Experimental Longitudinal study was done at AL-Tibri Medical College
Khalique-ur- Rehman +5 more
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