Treatment of Acute Tacrolimus Toxicity with Phenytoin in Solid Organ Transplant Recipients [PDF]
Case Reports in Transplantation, 2013 The pharmacokinetics of tacrolimus are influenced by many factors, including genetic variability, acute infections, liver dysfunction, and interacting medications, which can result in elevated concentrations.
Arin S. Jantz +5 more
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Phenytoin-induced Ogilvie syndrome: A rare case report [PDF]
SAGE Open Medical Case ReportsPhenytoin is a widely prescribed antiepileptic drug that is associated with various adverse effects, but gastrointestinal manifestations are rare. Therapeutic drug monitoring is essential for ensuring safe and effective dosing by measuring the drug ...
Joel Sabu +2 more
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Cardiac Collapse Secondary to Phenytoin Toxicity in a Neonate Treated with Extracorporeal Membrane Oxygenation Support (ECMO). [PDF]
J Med Toxicol, 2020 Introduction: Although medication toxicity is uncommon in neonates, there are several medications used in this population that pose a risk. Phenytoin has an increased risk of toxicity given its narrow therapeutic window and variations in drug elimination.
Knecht M +5 more
europepmc +3 more sources
Evaluation of neurotoxicity of drugs from morphological and electrophysiological endpoints using human iPSC-derived neural cell models [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionGenome-edited human induced pluripotent stem cells (iPSCs) were first generated in 2007, and have been applied in pharmaceutical research, development, and clinical therapy as an in vitro platform for personalised phenotyping and drug ...
Zhe Qu +8 more
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The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]
Clin Pharmacol TherDicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Shaul C +5 more
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Journal of Integrative Medicine and Research, 2023 The zero-order pharmacokinetics of phenytoin makes it a serious problem in pediatric emergency care since it can cause considerable dose-related toxicity.
Jenith Vijayalakshmi +4 more
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Phenytoin induced Chorea: commonly used antiepileptic drug causing a rare movement disorder [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Background: Phenytoin, a commonly prescribed antiepileptic drug, causes side effects like ataxia, tremor, hirsutism, gum hyperplasia, insomnia, confusion, headache and vertigo when used for longer duration.
Rambhupal NAGIREDDY +3 more
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Journal of Bahria University Medical and Dental College, 2023 Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn Oil (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design and setting: An Experimental Longitudinal study was done at AL-Tibri Medical College
Khalique-ur- Rehman +5 more
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CYP2C9 polymorphisms are associated with phenytoin toxicity in South-Indian epileptic patients
Journal of Dr. NTR University of Health Sciences, 2020 Background and Aims: The contribution of CYP2C9 in phenytoin metabolism is generally modest, but it increases with increasing serum phenytoin concentration.
Rakesh Reddy Reddigari +4 more
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Tacrolimus Induced Organ Failure: Reversal by Activation of the Cytochrome P450-3a System
Uro, 2021 Tacrolimus is the cornerstone component of all immunosuppressive regimens. Despite its long record of use, very little is known about its acute toxicity syndrome.
Dai D. Nghiem
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