Results 31 to 40 of about 621,544 (210)
Noncompliance leading to drug accumulation resulting in phenytoin toxicity
, 2003 Phenytoin is effective in suppressing tonic-clonic and partial seizures, and is widely used for initial therapy, particularly in adults. Ninety percent of phenytoin is protein bound and entirely eliminated by hepatic metabolism.
Akula, Ravi +3 more
core +2 more sources
Phenytoin toxicity with mandibular tremor secondary to intravenous administration
, 2002 The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day ...
F. Onat +3 more
core +2 more sources
In-vitro lymphocyte toxicity to a phenytoin metabolite in phenytoin induced cutaneous adverse drug eruptions [PDF]
, 2004 BACKGROUND: Phenytoin, one of the most commonly used antiepileptic drug, is associated with a wide spectrum of adverse drug eruptions. It is metabolized by the hepatic microsomal enzymes. The intermediate metabolites are arene oxides which accumulate due
Nithya Gogtay +4 more
core +3 more sources
DRUG INTERACTION INDUCED PHENYTOIN TOXICITY: A CASE REPORT [PDF]
, 2014 Phenytoin is a narrow therapeutic indexed antiepileptic drug. Many drugs competitively inhibit isoenzymes responsible for its metabolism when concurrently administered and increases the phenytoin plasma concentration leading to serious adverse effects ...
B.S, KESHAVA +4 more
core +1 more source
Acute Phenytoin Intoxication: Causes, Symptoms, Misdiagnoses, and Outcomes
Kaohsiung Journal of Medical Sciences, 2004 Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an important issue in emergency medicine.
Wen-Juh Hwang, Jing-Jane Tsai
doaj +1 more source
Antiepileptic drug-induced acute psychotic disorder in a nonepileptic patient: A definite prophecy
Apollo Medicine, 2019 Psychosis induced by antiepileptic drugs (AEDs) is considerably an iatrogenic adverse drug reaction. Various mechanisms operant in the development of iatrogenic psychiatric manifestations are proposed which necessitates analyzing complaints of ...
Mohit Dahiya +3 more
doaj +1 more source
Current Medical IssuesBackground: Phenytoin is a widely used, cost-effective anticonvulsant with a narrow therapeutic range, requiring close monitoring to avoid toxicity. Our aim was to investigate phenytoin toxicity in an emergency department setting, focusing on clinical ...
Nejah F. Ellouze +4 more
doaj +1 more source
Phenytoin: A Guide to Therapeutic Drug Monitoring
Proceedings of Singapore Healthcare, 2013 Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons) +1 more
doaj +1 more source
Cerebellar Atrophy with Phenytoin and Epilepsy
Pediatric Neurology Briefs, 1994 Cerebellar size measured by MRI was studied in a group of 36 adults (21 to 54 years, mean age 34 years) with intractable partial epilepsy treated with phenytoin longer than 4 years at the Epilepsy Center of the Long Island Jewish Medical Center, New Hyde
J Gordon Millichap
doaj +1 more source
N-octyl-modified magnetite NPs for optimization of solid phase extraction for trace analysis of phenytoin in real samples [PDF]
Nanomedicine Research Journal, 2019 objective: Phenytoin is an anti-seizure medication used to treat epilepsy, as well as to control arrhythmias (irregular heartbeat) and to treat migraine headaches and nerve pain.
Shaghayegh Raeisi +3 more
doaj +1 more source