Pheophorbide a: State of the Art [PDF]
Marine Drugs, 2020 Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is a photosensitizer that can induce significant anti-proliferative effects in several human ...
Assunta Saide +2 more
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Zinc-Substituted Pheophorbide A Is a Safe and Efficient Antivascular Photodynamic Agent
Pharmaceuticals, 2022 The present study focuses on the photodynamic activity of zinc-substituted pheophorbide a against human endothelial cells. Previously, zinc pheophorbide a has been shown to be a very potent photosensitizer but also a strong albumin binder.
Milena Szafraniec, Andrzej Gamian
exaly +4 more sources
Frontiers in EndocrinologyIntroductionPheophorbide A, a chlorophyll-breakdown product, is primarily investigated for its anti-oxidant and anti-inflammatory activity. Recent reports on pheophorbide A have shown its potential in lowering blood glucose levels, thus leading to the ...
Saptadipa Paul +3 more
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Photosensitizing Lipid Nanoparticles for Ferroptosis-Enhanced Photodynamic Cancer Therapy via GPX4 Silencing. [PDF]
Adv Healthc MaterPhotosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Bae GH +9 more
europepmc +2 more sources
OPTIMIZATION OF CONDITION FOR METHYL PHEOPHORBIDE A FORMATION AND CONVERSION TO CHLORIN E6
Tạp chí Khoa họcChlorin e6 is a stable chlorophyll derivative and can be used in photodynamic therapy (PDT) to treat cancer. One of the synthetic pathways of chlorin e6 is via the transformation of chlorophyll a to methyl pheophorbide a.
Nguyen Thi Thao, Vu Hong Son, Bui Kim Hoan, Nguyen Thi Minh Tu, Nguyen Thi Lan Anh, Nguyen Thanh Phuong* +1 more
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Pheophorbide A and Paclitaxel Bioresponsive Nanoparticles as Double-Punch Platform for Cancer Therapy [PDF]
Pharmaceutics, 2021 Cancer therapy is still a challenging issue. To address this, the combination of anticancer drugs with other therapeutic modalities, such as light-triggered therapies, has emerged as a promising approach, primarily when both active ingredients are ...
Francesca Moret +8 more
doaj +2 more sources
Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts
Life, 2021 Pheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (
Hwa Lee, Ho-Yong Park, Tae-Sook Jeong
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Applied Sciences, 2023 Microalgae, eukaryotic unicellular plants that are distributed worldwide, have been shown to exert anti-proliferative and anticancer activities on various human cancer cell lines.
Assunta Saide +3 more
doaj +2 more sources
Photomediated Larvicidal Activity of Pheophorbide a against Cercaria Larvae of Fasciola gigantica [PDF]
Scientifica, 2017 Fasciolosis is a parasitic disease caused by Fasciola gigantica. The freshwater snail Lymnaea acuminata is the intermediate host of F. gigantica which cause endemic fasciolosis in the northern part of India. To investigate larvicidal activity of pure and
Divya Jyoti Singh +2 more
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Plant-derived gold nanoparticles functionalized with pheophorbide-a for potent photodynamic therapy against A549 lung cancer cells [PDF]
Scientific ReportsLung cancer remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for more effective and safer therapeutic strategies.
Mehak Zahra +2 more
doaj +2 more sources