Results 11 to 20 of about 2,990 (179)

Plant-derived gold nanoparticles functionalized with pheophorbide-a for potent photodynamic therapy against A549 lung cancer cells [PDF]

Scientific Reports
Lung cancer remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for more effective and safer therapeutic strategies.
Mehak Zahra, Heidi Abrahamse, Blassan P. George   +2 more
doaj   +2 more sources

Improving photodynamic therapy efficacy in bladder cancer using polymer micelle-encapsulated pheophorbide a [PDF]

Translational Oncology
Background: Photodynamic diagnosis (PDD) is widely used in bladder cancer management, enabling fluorescence-guided detection of lesions through intravesical administration of photosensitizers such as hexaminolevulinate (Cysview®/Hexvix®).
Maxime Labroy, Stéphane Chabaud, Maud Durand, Isabelle Fourquaux, Stéphane Bolduc, François Bordeleau, Laure Gibot   +6 more
doaj   +2 more sources

Aggregation-induced stabilization of pheophorbide, a water-soluble chlorophyll derivative [PDF]

Frontiers in Nutrition
BackgroundChlorophyll (Chl) is a valuable natural pigment, but its application is limited by poor water solubility and photoinstability. This study focuses on the preparation of pheophorbide (Phide), a water-soluble chlorophyll derivative, and ...
Yixiao Liu, Yixiao Liu, Yishuang Liu, Yishuang Liu, Yangbin Wang, Yangbin Wang, Shuyu Wang, Shuyu Wang, Shuyi Shi, Shuyi Shi, Fangwei Li, Fangwei Li, Mingyong Zeng, Mingyong Zeng   +13 more
doaj   +2 more sources

Nanoparticles improved pheophorbide-a mediated photodynamic therapy for cancer. [PDF]

Lasers Med Sci
Abstract The increased cancer incidence and mortality rates have made researchers continue to explore different types of effective and less toxic cancer therapies. Photodynamic therapy (PDT) is an alternative cancer treatment modality with reduced side effects.
Fakudze N, Abrahamse H, George B.
europepmc   +3 more sources

Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics [PDF]

Scientific Reports
Diabetes is a pandemic disease that causes the loss of control of glucose regulation in the organism, in consequence of dysfunction of insulin production or functionality.
Tiago Ribeiro, Mariana Reis, Vitor Vasconcelos, Ralph Urbatzka   +3 more
doaj   +2 more sources

Self-Assembled Nanoparticles with Kynureninase-Fc Fusion Protein and Pheophorbide A for Photodynamic Immunometabolic Cancer Therapy [PDF]

Journal of Functional Biomaterials
Background/Objectives: Aberrant metabolism in tumors exacerbates the immunosuppressive tumor microenvironment. The immunosuppressive metabolite kynurenine inhibits the activation of effector T cells.
Chen Zhang, Afeng Yang, Hongzheng Lin, Zhe Li, Wei Lu   +4 more
doaj   +2 more sources

ROS-responsive tegafur-pheophorbide a conjugate-loaded microneedles for deep drug delivery and chemo-photodynamic therapy of superficial tumors [PDF]

International Journal of Pharmaceutics: X
Superficial tumors, including breast cancer, melanoma, and oral carcinoma, pose significant treatment challenges due to their anatomical location and the inherent limitations of conventional therapies, such as systemic toxicity and poor tumor specificity.
Anning Li, Yingjie Ma, Yunfeng Dai, Yibin Guo, Yanjun He, Sihan Chen, Xinjie Su, Chenxi Fang, Long Chen, Meitao Duan, Ming Chen, Jungang Ren, Li Wang, Chen Wang, Zhiqiang Zhang   +14 more
doaj   +2 more sources

Mechanism of photodynamic activity of pheophorbides

Journal of Biomedical Optics, 2001
Plasmid DNA is efficiently photocleaved by sodium pheophorbides (Na-Phdes) a and b in the absence of oxygen as well as in the presence of oxygen. Fluorescence microscopic observation shows a rapid incorporation of Na-Phde a into nuclei, mitochondria, and lysosome of human oral mucosa cells.
C, Tanielian, M, Kobayashi, C, Wolff
openaire   +2 more sources

Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition [PDF]

Cancer Research, 2004
Abstract Pheophorbide a (PhA), a chlorophyll catabolite, was shown to be an ABCG2 substrate based on Abcg2−/− knockout mouse studies (J. W. Jonker et al., Proc. Natl. Acad. Sci. USA, 99: 15649–15654, 2002). We developed a functional assay for ABCG2 using PhA and the ABCG2 inhibitor fumitremorgin C.
Robert W, Robey, Kenneth, Steadman, Orsolya, Polgar, Kuniaki, Morisaki, Margaret, Blayney, Prakash, Mistry, Susan E, Bates   +6 more
openaire   +2 more sources

Pheophorbide a as a photosensitizer in photodynamic therapy: In vivo considerations [PDF]

Cancer Biology & Therapy, 2009
Commentary to:Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma Patrick Ming-Kuen Tang, Xiao-Zhuo Liu, Dong-Mei Zhang, Wing-Ping Fong and Kwok-Pui ...
Theresa, Busch, Keith A, Cengel, Jarod, Finlay   +2 more
openaire   +2 more sources