Results 11 to 20 of about 2,897 (173)

Self-Assembled Nanoparticles with Kynureninase-Fc Fusion Protein and Pheophorbide A for Photodynamic Immunometabolic Cancer Therapy [PDF]

Journal of Functional Biomaterials
Background/Objectives: Aberrant metabolism in tumors exacerbates the immunosuppressive tumor microenvironment. The immunosuppressive metabolite kynurenine inhibits the activation of effector T cells.
Chen Zhang, Afeng Yang, Hongzheng Lin, Zhe Li, Wei Lu   +4 more
doaj   +2 more sources

ROS-responsive tegafur-pheophorbide a conjugate-loaded microneedles for deep drug delivery and chemo-photodynamic therapy of superficial tumors [PDF]

International Journal of Pharmaceutics: X
Superficial tumors, including breast cancer, melanoma, and oral carcinoma, pose significant treatment challenges due to their anatomical location and the inherent limitations of conventional therapies, such as systemic toxicity and poor tumor specificity.
Anning Li, Yingjie Ma, Yunfeng Dai, Yibin Guo, Yanjun He, Sihan Chen, Xinjie Su, Chenxi Fang, Long Chen, Meitao Duan, Ming Chen, Jungang Ren, Li Wang, Chen Wang, Zhiqiang Zhang   +14 more
doaj   +2 more sources

The metabolic ability of swallowtails results in the production of bioactive substances from plant components. [PDF]

PLoS ONE
Host plant selection may depend on the metabolic system in herbivorous insects. Although oligophagous insects take up specific host plant components, how host plant components and their biological activities are altered through their metabolic systems ...
Miho Nakano, Takuma Sakamoto, Yoshiyuki Itoh, Yoshikazu Kitano, Kaori Tsukakoshi, Hidemasa Bono, Hiroko Tabunoki   +6 more
doaj   +2 more sources

Effect of Slightly Acidic Electrolyzed Water on Chlorophyll Degradation in Postharvest Broccoli [PDF]

Shipin Kexue, 2023
To explore the effect of slightly acidic electrolyzed water (SAEW) on chlorophyll degradation in postharvest broccoli, the pattern of changes in the color, total chlorophyll content, chlorophyll derivative content, chlorophyll degrading enzyme activities,
HAN Ying, SUN Ying, GUO Feng, WANG Xinyu, ZHAO Anqi, WU Zhaoxia, LI Pengxia, LI Guofeng, HU Huali
doaj   +1 more source

Zinc-Substituted Pheophorbide A Is a Safe and Efficient Antivascular Photodynamic Agent

Pharmaceuticals, 2022
The present study focuses on the photodynamic activity of zinc-substituted pheophorbide a against human endothelial cells. Previously, zinc pheophorbide a has been shown to be a very potent photosensitizer but also a strong albumin binder.
Milena J. Szafraniec, Monika Toporkiewicz, Andrzej Gamian   +2 more
doaj   +1 more source

Phototoxicity of Pheophorbide A Extracted from Gracilaria Lemaneiformis on Six Kinds of Cancer Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the photodynamic antitumor activity and chemical characteristics of pheophorbide A (PPBa)in vitro. Methods Breast cancer cells (MCF-7), lung cancer cells (A549), cervical cancer cells (HeLa), and three kinds of hepatoma cells ...
HUANG Xixiang, CAI Xiaoxuan, WANG Tianji, HUANG Miaoen, LI Li, LYU Yingnian   +5 more
doaj   +1 more source

Mechanism of photodynamic activity of pheophorbides

Journal of Biomedical Optics, 2001
Plasmid DNA is efficiently photocleaved by sodium pheophorbides (Na-Phdes) a and b in the absence of oxygen as well as in the presence of oxygen. Fluorescence microscopic observation shows a rapid incorporation of Na-Phde a into nuclei, mitochondria, and lysosome of human oral mucosa cells.
C, Tanielian, M, Kobayashi, C, Wolff
openaire   +2 more sources

The Diatom Cylindrotheca closterium and the Chlorophyll Breakdown Product Pheophorbide a for Photodynamic Therapy Applications

Applied Sciences, 2023
Microalgae, eukaryotic unicellular plants that are distributed worldwide, have been shown to exert anti-proliferative and anticancer activities on various human cancer cell lines.
Assunta Saide, Gennaro Riccio, Adrianna Ianora, Chiara Lauritano   +3 more
doaj   +1 more source

Effect of Blue Light-Emitting Diode (LED) Irradiation on Chlorophyll Metabolism in Ethylene-Degreened Early-Season Satsuma Mandarin Fruit [PDF]

Shipin Kexue, 2023
Early-season Satsuma mandarin fruit produced in Chongqing are usually harvested when the flesh reaches the acceptable internal maturity standards, while the peel is still green. In order to solve this problem, ethylene degreening treatment is widely used
CAO Tingting, ZENG Kaifang, DENG Lili
doaj   +1 more source

Two New Phloroglucinol Derivatives and Five Photosensitizing Pheophorbides from Leaves (Salam)

Natural Product Communications, 2012
Two new phloroglucinol derivatives, identified as anthuminoate ( 1 ) and anthuminone ( 2 ), were isolated from the ichthyotoxic ethyl acetate fraction of Syzygium polyanthum leaves.
Lee Wei Har, Khozirah Shaari, Lee Hong Boon, Fadzly A. Kamarulzaman, Intan S. Ismail   +4 more
doaj   +1 more source