Pheophorbide a: State of the Art [PDF]
Marine Drugs, 2020 Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is a photosensitizer that can induce significant anti-proliferative effects in several human ...
Assunta Saide +2 more
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Zinc-Substituted Pheophorbide A Is a Safe and Efficient Antivascular Photodynamic Agent [PDF]
Pharmaceuticals, 2022 The present study focuses on the photodynamic activity of zinc-substituted pheophorbide a against human endothelial cells. Previously, zinc pheophorbide a has been shown to be a very potent photosensitizer but also a strong albumin binder.
Milena J. Szafraniec +2 more
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Nanoparticles improved pheophorbide-a mediated photodynamic therapy for cancer. [PDF]
Lasers Med SciAbstract The increased cancer incidence and mortality rates have made researchers continue to explore different types of effective and less toxic cancer therapies. Photodynamic therapy (PDT) is an alternative cancer treatment modality with reduced side effects. It is comprised of three components, a photosensitizer, molecular oxygen and light.
Fakudze N, Abrahamse H, George B.
europepmc +3 more sources
Plant-derived gold nanoparticles functionalized with pheophorbide-a for potent photodynamic therapy against A549 lung cancer cells [PDF]
Scientific ReportsLung cancer remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for more effective and safer therapeutic strategies.
Mehak Zahra +2 more
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Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis [PDF]
Frontiers in EndocrinologyIntroductionPheophorbide A, a chlorophyll-breakdown product, is primarily investigated for its anti-oxidant and anti-inflammatory activity. Recent reports on pheophorbide A have shown its potential in lowering blood glucose levels, thus leading to the ...
Saptadipa Paul +3 more
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Improving photodynamic therapy efficacy in bladder cancer using polymer micelle-encapsulated pheophorbide a [PDF]
Translational OncologyBackground: Photodynamic diagnosis (PDD) is widely used in bladder cancer management, enabling fluorescence-guided detection of lesions through intravesical administration of photosensitizers such as hexaminolevulinate (Cysview®/Hexvix®).
Maxime Labroy +6 more
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Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics [PDF]
Scientific ReportsDiabetes is a pandemic disease that causes the loss of control of glucose regulation in the organism, in consequence of dysfunction of insulin production or functionality.
Tiago Ribeiro +3 more
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Self-Assembled Nanoparticles with Kynureninase-Fc Fusion Protein and Pheophorbide A for Photodynamic Immunometabolic Cancer Therapy [PDF]
Journal of Functional BiomaterialsBackground/Objectives: Aberrant metabolism in tumors exacerbates the immunosuppressive tumor microenvironment. The immunosuppressive metabolite kynurenine inhibits the activation of effector T cells.
Chen Zhang +4 more
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The metabolic ability of swallowtails results in the production of bioactive substances from plant components. [PDF]
PLoS ONEHost plant selection may depend on the metabolic system in herbivorous insects. Although oligophagous insects take up specific host plant components, how host plant components and their biological activities are altered through their metabolic systems ...
Miho Nakano +6 more
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Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer
Drug Delivery, 2022 Photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted research interest for their noninvasive nature and selective treatment of tumor tissues.
Zhiqin Zhang +11 more
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