Pheophorbide a: State of the Art [PDF]
Marine Drugs, 2020 Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is a photosensitizer that can induce significant anti-proliferative effects in several human ...
Assunta Saide +2 more
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Pharmaceutics, 2021 Cancer therapy is still a challenging issue. To address this, the combination of anticancer drugs with other therapeutic modalities, such as light-triggered therapies, has emerged as a promising approach, primarily when both active ingredients are ...
Francesca Moret +2 more
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Photosensitizing Lipid Nanoparticles for Ferroptosis-Enhanced Photodynamic Cancer Therapy via GPX4 Silencing. [PDF]
Adv Healthc MaterPhotosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Bae GH +9 more
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Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts
Life, 2021 Pheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (
Tae-Sook Jeong, Hwa Lee, Ho-Yong Park
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Plant-derived gold nanoparticles functionalized with pheophorbide-a for potent photodynamic therapy against A549 lung cancer cells [PDF]
Scientific ReportsLung cancer remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for more effective and safer therapeutic strategies.
Mehak Zahra +2 more
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Aggregation-induced stabilization of pheophorbide, a water-soluble chlorophyll derivative [PDF]
Frontiers in NutritionBackgroundChlorophyll (Chl) is a valuable natural pigment, but its application is limited by poor water solubility and photoinstability. This study focuses on the preparation of pheophorbide (Phide), a water-soluble chlorophyll derivative, and ...
Yixiao Liu +13 more
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Improving photodynamic therapy efficacy in bladder cancer using polymer micelle-encapsulated pheophorbide a [PDF]
Translational OncologyBackground: Photodynamic diagnosis (PDD) is widely used in bladder cancer management, enabling fluorescence-guided detection of lesions through intravesical administration of photosensitizers such as hexaminolevulinate (Cysview®/Hexvix®).
Maxime Labroy +6 more
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Frontiers in EndocrinologyIntroductionPheophorbide A, a chlorophyll-breakdown product, is primarily investigated for its anti-oxidant and anti-inflammatory activity. Recent reports on pheophorbide A have shown its potential in lowering blood glucose levels, thus leading to the ...
Nikhil R Gandasi +2 more
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Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics [PDF]
Scientific ReportsDiabetes is a pandemic disease that causes the loss of control of glucose regulation in the organism, in consequence of dysfunction of insulin production or functionality.
Tiago Ribeiro +3 more
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Nanoparticles improved pheophorbide-a mediated photodynamic therapy for cancer. [PDF]
Lasers Med SciAbstract The increased cancer incidence and mortality rates have made researchers continue to explore different types of effective and less toxic cancer therapies. Photodynamic therapy (PDT) is an alternative cancer treatment modality with reduced side effects.
Fakudze N, Abrahamse H, George B.
europepmc +3 more sources