Results 131 to 140 of about 6,310 (247)

Disease outcomes associated with the weighted GRS of urate in PheWAS analysis.

, 2019
Disease outcomes associated with the weighted GRS of urate in PheWAS analysis.
Harry Campbell (30339), Peter Joshi (3819646), Tian Yang (318007), Ioanna Tzoulaki (257920), Maria Timofeeva (3147669), Xue Li (285380), Aliya Gifford (5264842), Evropi Theodoratou (149881), Tim Varley (7517381), Wei-Qi Wei (4232797), Joshua C. Denny (6830084), Athina Spiliopoulou (5626562), Yazhou He (5626556), Paul Mckeigue (7517384), Xiangrui Meng (3566795)   +14 more
core   +1 more source

Study specific COVID-19 severity “B2_ALL” PRS PheWAS on pre-pandemic conditions in EUR individuals, adjusted for BMI.

, 2023
Study specific COVID-19 severity “B2_ALL” PRS PheWAS on pre-pandemic conditions in EUR individuals, adjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source

Genome-wide association studies reveal differences in genetic susceptibility between single events vs. recurrent events of atrial fibrillation and myocardial infarction: the HUNT study

Frontiers in Cardiovascular Medicine
Genetic research into atrial fibrillation (AF) and myocardial infarction (MI) has predominantly focused on comparing afflicted individuals with their healthy counterparts.
Martina Hall, Martina Hall, Anne Heidi Skogholt, Ida Surakka, Haavard Dalen, Haavard Dalen, Haavard Dalen, Eivind Almaas, Eivind Almaas   +8 more
doaj   +1 more source

PheWAS association results (p-value < 1E-04) of 52 susceptibility SNPs for diverticular diseases in MA, EA, AA participants.

, 2023
PheWAS association results (p-value < 1E-04) of 52 susceptibility SNPs for diverticular diseases in MA, EA, AA participants.
James G. Linneman (15572966), Luke V. Rasmussen (3769519), Andrew Cagan (482180), Annapoorani Veerappan (15572969), Joshua C. Denny (6830084), M. Geoffrey Hayes (7911173), Yoonjung Yoonie Joo (14296640), Frederick T. J. Lin (9016487), William K. Thompson (15572957), Laura J. Rasmussen-Torvik (8636061), Jyotishman Pathak (667676), Stephen B. Ellis (15572963), Andrew J. Gawron (13678158), Erwin Bottinger (79844), Kenneth M. Borthwick (15572960), Abel N. Kho (6830060), Mariza de Andrade (31845), David S. Carrell (8679591), Rex L. Chisholm (15572972), Peggy L. Peissig (6830081), Jennifer A. Pacheco (6830072), Ning Shang (11598436), Omri Gottesman (133442), Maureen E. Smith (3769522), Gerard Tromp (63007)   +24 more
core   +1 more source

Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb.

PLoS Genetics, 2019
Polygenic risk scores (PRS) are designed to serve as single summary measures that are easy to construct, condensing information from a large number of genetic variants associated with a disease.
Lars G Fritsche, Lauren J Beesley, Peter VandeHaar, Robert B Peng, Maxwell Salvatore, Matthew Zawistowski, Sarah A Gagliano Taliun, Sayantan Das, Jonathon LeFaive, Erin O Kaleba, Thomas T Klumpner, Stephanie E Moser, Victoria M Blanc, Chad M Brummett, Sachin Kheterpal, Gonçalo R Abecasis, Stephen B Gruber, Bhramar Mukherjee   +17 more
doaj   +1 more source

PheWAS results of rs10455872 on 12,759 individuals adjusted by sex and age.

, 2019
PheWAS results of rs10455872 on 12,759 individuals adjusted by sex and age.
QiPing Feng (5692676), Jeremy L. Warner (3934727), Wei-Qi Wei (4232797), Patrick Wu (6331307), Juan Zhao (109151), Joshua C. Denny (107665)   +5 more
core   +1 more source

Study-specific COVID-19 severity “B2_ALL” PRS PheWAS on pre-pandemic conditions in EUR individuals, unadjusted for BMI.

, 2023
Study-specific COVID-19 severity “B2_ALL” PRS PheWAS on pre-pandemic conditions in EUR individuals, unadjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source

PheWAS of the genome-wide significant variants in the meta-analysis loci ±1Mb around the index variant.

, 2023
PheWAS of the genome-wide significant variants in the meta-analysis loci ±1Mb around the index variant.
Mika Rämet (133146), Antti M. Haapalainen (6836669), Louis J. Muglia (7841168), Anu Pasanen (6836672), Aarno Palotie (41342), Minna K. Karjalainen (17271458), Ge Zhang (112487), Hannele Laivuori (178533), Marja Ojaniemi (230956), Mikko Hallman (114373), Bo Jacobsson (253778), Bjarke Feenstra (206249), Heli Tiensuu (6836666)   +12 more
core   +1 more source

Genome‐Wide Meta‐Analysis of Parkinson's Disease Associated Genetic Loci and Validation of Therapeutic Targets

Brain and Behavior
Background To identify genetic loci associated with Parkinson's disease (PD) through a genome‐wide meta‐analysis, to screen for druggable genes significantly linked to PD risk, and evaluate their potential as therapeutic targets. Methods Data from DGIdb,
Shan Yang, Qinfen Wu, Xinling Yang
doaj   +1 more source

Identifying potential causal effects of Parkinson’s disease: A polygenic risk score-based phenome-wide association and mendelian randomization study in UK Biobank

npj Parkinson's Disease
There is considerable uncertainty regarding the associations between various risk factors and Parkinson’s Disease (PD). This study systematically screened and validated a wide range of potential PD risk factors from 502,364 participants in the UK Biobank.
Changhe Shi, Dongrui Ma, Mengjie Li, Zhiyun Wang, Chenwei Hao, Yuanyuan Liang, Yanmei Feng, Zhengwei Hu, Xiaoyan Hao, Mengnan Guo, Shuangjie Li, Chunyan Zuo, Yuemeng Sun, Mibo Tang, Chengyuan Mao, Chan Zhang, Yuming Xu, Shilei Sun   +17 more
doaj   +1 more source