Phenome-wide association studies between SERINC2 and neuropsychiatric disorders [PDF]
Frontiers in PsychiatryObjectivesSERINC2 has been associated with alcoholism, bipolar disorder and autism, but the comparability and specificity issues of the findings remain unaddressed.
Ping Liu +15 more
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HCLC-FC: A novel statistical method for phenome-wide association studies. [PDF]
PLoS ONE, 2022 The emergence of genetic data coupled to longitudinal electronic medical records (EMRs) offers the possibility of phenome-wide association studies (PheWAS).
Xiaoyu Liang +3 more
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CoPheScan: phenome-wide association studies accounting for linkage disequilibrium [PDF]
Nature Communications, 2023 Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on ...
Ichcha Manipur +6 more
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A simulation study investigating power estimates in phenome-wide association studies [PDF]
BMC Bioinformatics, 2018 Background Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures.
Anurag Verma +6 more
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Maturation and application of phenome-wide association studies [PDF]
Trends in Genetics, 2022 In the past 10 years since its introduction, phenome-wide association studies (PheWAS) have uncovered novel genotype-phenotype relationships. Along the way, PheWAS have evolved in many aspects as a study design with the expanded availability of large data repositories with genome-wide data linked to detailed phenotypic data.
Dana Crawford
exaly +4 more sources
Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum [PDF]
Frontiers in Genetics, 2023 High-throughput genomic and phenomic data have enhanced the ability to detect genotype-to-phenotype associations that can resolve broad pleiotropic effects of mutations on plant phenotypes.
J. Lucas Boatwright +5 more
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Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies [PDF]
BMC GenomicsBackground Analyses of a bipartite Genotype and Phenotype Network (GPN), linking the genetic variants and phenotypes based on statistical associations, provide an integrative approach to elucidate the complexities of genetic relationships across diseases
Xuewei Cao +4 more
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Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci [PDF]
World Allergy Organization JournalBackground: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR ...
Xingling Tan, MD +4 more
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Phenome-wide association studies across large population cohorts support drug target validation [PDF]
Nature Communications, 2018 Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al.
Dorothée Diogo +33 more
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Using phenome-wide association studies to examine the effect of environmental exposures on human health [PDF]
Environment International, 2019 The field of environmental epidemiology has been using “-omics” technologies, including the exposome, metabolome, and methylome, to understand the potential effects and biological pathways of a number of environmental pollutants. However, the majority of
Joseph M. Braun +3 more
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