Results 41 to 50 of about 10,755 (158)

Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population

Frontiers in Genetics, 2021
Clinical conditions correlated with elevated triglyceride levels are well-known: coronary heart disease, hypertension, and diabetes. Underlying genetic and phenotypic mechanisms are not fully understood, partially due to lack of coordinated genotypic ...
Robert W. Read, Karen A. Schlauch, Vincent C. Lombardi, Elizabeth T. Cirulli, Nicole L. Washington, James T. Lu, Joseph J. Grzymski, Joseph J. Grzymski   +7 more
doaj   +1 more source

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Nature Communications, 2020
Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed
Xueyi Shen, David M. Howard, Mark J. Adams, W. David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh   +8 more
doaj   +1 more source

A Phenome-Wide Association Study of Drugs and Comorbidities Associated With Gastrointestinal Dysfunction in Systemic Sclerosis

The Journal of Rheumatology, 2023
ObjectiveTo explore the causes of and contributors to gastrointestinal (GI) dysfunction in systemic sclerosis (SSc) in a phenome-wide association study (PheWAS), using real-world clinical records data.MethodsTwelve thousand five hundred thirty-five documented clinical assessments of 2058 consenting individuals with SSc at the Royal Free Hospital (UK ...
Rory H. Maclean, Fiza Ahmed, Voon H. Ong, Charles D. Murray, Christopher P. Denton   +4 more
openaire   +3 more sources

Revealing polygenic pleiotropy using genetic risk scores for asthma

HGG Advances, 2023
Summary: In this study we examined how genetic risk for asthma associates with different features of the disease and with other medical conditions and traits.
Matthew Dapas, Yu Lin Lee, William Wentworth-Sheilds, Hae Kyung Im, Carole Ober, Nathan Schoettler   +5 more
doaj   +1 more source

Phenome-wide association studies as a research tool for identifying new pathogenetic links

Кардиоваскулярная терапия и профилактика
The accumulation of biospecimens associated with large-scale clinical data (data from electronic medical records, epidemiological and other large-scale studies) has made it possible to conduct studies aimed at studying associations between genetic ...
N. A. Mashkina, A. I. Ershova, O. V. Kopylova, O. M. Drapkina   +3 more
doaj   +1 more source

Novel and known morbidities of leukodystrophies identified using a phenome-wide association study [PDF]

Neurology Clinical Practice, 2020
To determine shared comorbidities and to identify underrecognized or unexpected morbidities in children with leukodystrophies using an unbiased phenome-wide association study (PheWAS) analysis of a nationwide pediatric clinical and financial database.Data were extracted from the Pediatric Health Information System database. Patients with leukodystrophy
Joshua L. Bonkowsky, Jacob Wilkes, Jian Ying, Wei-Qi Wei   +3 more
openaire   +2 more sources

A population-based phenome-wide association study of cardiac and aortic structure and function [PDF]

Nature Medicine, 2020
Differences in cardiac and aortic structure and function are associated with cardiovascular diseases and a wide range of other types of disease. Here we analyzed cardiovascular magnetic resonance images from a population-based study, the UK Biobank, using an automated machine-learning-based analysis pipeline.
Wenjia Bai, Hideaki Suzuki, Jian Huang, Catherine Francis, Shuo Wang, Giacomo Tarroni, Florian Guitton, Nay Aung, Kenneth Fung, Steffen E. Petersen, Stefan K. Piechnik, Stefan Neubauer, Evangelos Evangelou, Abbas Dehghan, Declan P. O’Regan, Martin R. Wilkins, Yike Guo, Paul M. Matthews, Daniel Rueckert   +18 more
openaire   +4 more sources

The extracellular matrix phenome across species

Matrix Biology Plus, 2020
Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants.
Cyril Statzer, Collin Y. Ewald
doaj   +1 more source

The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study

Frontiers in Oncology, 2022
BackgroundProstate cancer is the second most common cancer in males worldwide, and multitudes of factors have been reported to be associated with prostate cancer risk.ObjectivesWe aim to conduct the phenome-wide exposed-omics analysis of the risk factors
Dongqing Gu, Mingshuang Tang, Yutong Wang, Huijie Cui, Min Zhang, Ye Bai, Ziqian Zeng, Yunhua Tan, Xin Wang, Ben Zhang   +9 more
doaj   +1 more source

Phenome‐Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis [PDF]

Arthritis & Rheumatology, 2017
ObjectivePatients with rheumatoid arthritis (RA) develop autoantibodies against a spectrum of antigens, but the clinical significance of these autoantibodies is unclear. Using a phenome‐wide association study (PheWAS) approach, we examined the association between autoantibodies and clinical subphenotypes of RA.MethodsThis study was conducted in a ...
Liao, Katherine, Sparks, Jeffrey, Hejblum, Boris P., Kuo, I-Hsin, Cui, Jing, Lahey, Lauren, Cagan, Andrew, Gainer, Vivian, Liu, Weidong, Cai, Tony, Sokolove, Jeremy, Cai, Tianxi   +11 more
openaire   +5 more sources