Results 41 to 50 of about 21,579,379 (182)
Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records
BMC Medical Genomics, 2020 Background Obstructive sleep apnea (OSA) is defined by frequent episodes of reduced or complete cessation of airflow during sleep and is linked to negative health outcomes.Olivia J. Veatch, Christopher R. Bauer, Brendan T. Keenan, Navya S. Josyula, Diego R. Mazzotti, Kanika Bagai, Beth A. Malow, Janet D. Robishaw, Allan I. Pack, Sarah A. Pendergrass +9 moredoaj +1 more sourceHuman and Machine Intelligence Together Drive Drug Repurposing in Rare Diseases
Frontiers in Genetics, 2021 Repurposing is an increasingly attractive method within the field of drug development for its efficiency at identifying new therapeutic opportunities among approved drugs at greatly reduced cost and time of more traditional methods.Anup P. Challa, Anup P. Challa, Nicole M. Zaleski, Rebecca N. Jerome, Robert R. Lavieri, Jana K. Shirey-Rice, April Barnado, Christopher J. Lindsell, David M. Aronoff, David M. Aronoff, David M. Aronoff, Leslie J. Crofford, Raymond C. Harris, T. Alp Ikizler, Ingrid A. Mayer, Kenneth J. Holroyd, Jill M. Pulley +16 moredoaj +1 more sourceIntrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen +10 morewiley +1 more sourceAssociation of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. [PDF]
, 2011 The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA.Keating, BJ, Boehnke, M., Lawrence, Robert W, Ridker, P.M., Alexander, M., Elosua, R., Zukowska-szczechowska, E., Philip Howard, Boerwinkle, E., Dong, Y., Parker, A.N., van der Schouw, Y.T., Hicks, Andrew A, Palmer, L.J., Zukowska-Szczechowska, Ewa, Palmer, N.D., Chris O'Donnell, Mangino, M., Colin A. McKenzie, Milaneschi, Yuri, Yen-Pei C. Chang, Toshiko Tanaka, Young, J. Hunter, Martin, Lisa W., Rettig, Rainer, Sudha Seshadri, Polak, J. F., Lathrop, Mark, Marmot, M. G., Josef F. Polak, Maciej Tomaszewski, Longstreth, Will T, Cooper, Richard S, Hedblad, Bo, Kuznetsova, T., Groop, L., Steve E. Humphries, Cooper, Richard S., Barroso, Inês, Rick Twee-Hee Ong, Cooper, J. A., Yoshikuni Kita, Ong, R.T., Loos, Ruth J F, Hugh Watkins, Vinay, D G, Chambers, John C, Schwartz, Steven M, Tai, E.S., Charles S. Janipalli, Janos Terzic, Mika Ala-Korpela, Altshuler, D., Keating, B., Maris Laan, Hofman, A., Igl, W., Daniel L. Dries, Smith, Albert V, Ongen, Halit, Thomas H. Mosley, Grassler, J., Seielstad, Mark, Heyo K. Kroemer, Miki, T., Vartiainen, Erkki, Steinle, N.I., Markku Laakso, EchoGen consortium, [Unknown], Keating, Brendan J, Ludwig, Barbara, Chang, Yen-Pei C, Bergman, R.N., Salako, T., Brand, E., Iwai, N., Salomaa, Veikko, Joel N. Hirschorn, Collins, Francis S, Go, M.J., Johnson, T, Wichmann, H.- E., Farlow, Deborah N., Hopewell, J. C., Hunt, S.C., Sue Shaw-Hawkins, Kurt K. Lohman, Orru, Marco, Najjar, S., Lehtimäki, Terho, Lori L. Bonnycastle, Tripathy, Vikal, Abbas Dehghan, Solomon K. Musani, Uitterlinden, Andre G, et al., Cuno S.P.M. Uiterwaal, Andrew D. Johnson, Valur Emilsson, Wong, T. Y., Larson, M. G., Mosley, Thomas H, Benjamin F. Voight, Laan, M., Navis, G., Michiel L. Bots, Farlow, D. N., Nalls, M.A., Zhang, W., Rice, K.M., Gyllensten, Ulf B, Mani, K Radha, Wyatt, S. B., Vitart, Veronique, Emilsson, V., Johannes Kettunen, Hercberg, S., Brown, Morris J, Nguyen, Khanh-Dung Hoang, Michael G. Marmot, Rao, D. C., John C. Chambers, Voight, B. F., Franceschini, N, Aravinda Chakravarti, Scuteri, Angelo, Lucas, Gavin, Sun, Y.V., Khanh-Dung Hoang Nguyen, Santhi Ganesh, Dominiczak, Anna F, Caulfield, M.J., Wright, A.F., Talmud, Philippa J, Forrester, Terrence, Kooner, J.S., Robert W. Lawrence, Cooper, M. N., Hadley, D., Gaunt, T.R., Lyon, HN, Fernando Rivadeneira, Jaakko Tuomilehto, Talmud, P.J., Gyllensten, U. B., George Davey Smith, Ulf B. Gyllensten, Lyon, Helen N, Longstreth, W.T., Shih-Jen Hwang, Wareham, N.J., Eaton, C. B., Li, Y., Toshio Ogihara, Kooner, Jaspal S, Giuseppe Matullo, Peter P. Pramstaller, Pihur, V., Steinle, N. I., Burton, P.R., Heath, S., Mariacorsi, A., Verwoert, G. C., Erdmann, Jeanette, Nicholas J. Wareham, Eva Brand, Samani, N. J., Artigas, M.S., Sharma, Pankaj, Xiaofeng Zhu, Galan, P., Li, YL, van Gilst, Wiek H, Van Der Harst, P., Vineis, P., Collins, F.S., Tai, E Shyong, Jackson, A.U., Grässler, Jürgen, Wilson, James F, Palmer, Lyle J, Danish Saleheen, Whincup, P.H., Lee, J.-y., Tukiainen, T., Okamura, T., Garcia, M., Dong, Yanbin, Dorairajan Prabhakaran, Judith A. Hoffman Bolton, Kang, S.J., Casas, J. P., Dehghan, Abbas, Kroemer, H. K., KidneyGen consortium, [Unknown], Penman, Alan D., Bamidele O. Tayo, Melissa Garcia, Verwoert, Germaine C, Perola, Markus, Cristian Pattaro, Köttgen, Anna, Rice, K. M., Alex N. Parker, Vinay, DG, Islam, M., McKenzie, Colin A, Van Der Schouw, Y. T., Toby Johnson, Meschia, James F, Hercberg, Serge, Longstreth, W. T., Pramstaller, P. P., Parker, A. N., Bornstein, S. R., Beckmann, Jacques S, Hicks, A.A., Min JinGo, Volker, U., Susana Eyheramendy, Fox, Ervin R., Hartikainen, A.-l., Will T. Longstreth, Townsend, R.R., Brand, Eva, Jacques S. Beckmann, Anna-Liisa Hartikainen, Polasek, Ozren, Kumari, M., Nish Chaturvedi, Lynne E. Wagenknecht, Polak, J., Louise V. Wain, Tzoulaki, I., Jing Hua Zhao, Soininen, P., Penman, A. D., Sehmi, J.S., Anna Köttgen, Mosley, Thomas H., Luan, J., Cristiano Fava, Rotter, J.I., Steven C. Hunt, Psaty, B. M., Alanna C. Morrison, Ehret, Georg B, Gavin Lucas, Debbie A. Lawlor, Hoffman Bolton, Judith A, Heckbert, S. R., Umemura, Satoshi, Mosley, T.H., Wild, Sarah H, Jackson, Anne U, Townsend, RR, Raitakari, Olli, JinGo, Min, Rudan, I., Snieder, Harold, Stephan J.L. Bakker, Thomas J. Wang, Annika Rosengren, Stancakova, A., Fabsitz, R. R., Connell, John M, Kangas, A.J., Eyheramendy, Susana, Tim D. Spector, Palmas, W, Dag S. Thelle, Megan E. Rudock, Van Gilst, W. H., Stancáková, Alena, Thor Aspelund, Shaw-hawkins, S., Ehret, G. B., Hernandez, Dena, Shrine, N.R., Ramachandran, Vasan S, Oostra, Ben A, Andrew Taylor, Kivimaki, M., Chen, M.H., Hyung-Lae Kim, Keating, B. J., Kooner, J. S., Zhao, J. H., Yajnik, C. S., Volzke, H., Wilmar Igl, Dominiczak, A. F., Laakso, Markku, Peden, J. F., Ewa Zukowska-Szczechowska, Jaspal S. Kooner, Polak, JF, Smita R. Kulkarni, Thomas Meitinger, Coresh, J., Hadley, David, Zhu, Haidong, Kardia, S. L. R., Elliott, P., O'Connell, Jeffrey R, Laitinen, J., Veldre, G., Palmer, L. J., Nanette I. Steinle, Casas, J.P., Palmas, W., Hilton, Gina, Helen N. Lyon, Swift, A. J., Bornstein, Stefan R, Altshuler, David, Matthias Olden, Chen, M.-h., Rotimi, C. N., Doumatey, AP, Newton-cheh, C., Francis S. Collins, Hwang, Shih-Jen, Uiterwaal, C.S., Luan, Jian'an, Chandak, G. R., Launer, Lenore, Salako, Tunde, Panos Deloukas, Stringham, Heather M, Najaf Amin, Farlow, DN, Beilby, John P, Vinay, D. G., Smith, N.L., Jennifer L. Bragg-Gresham, Elosua, Roberto, Caulfield, Mark J., Dries, D. L., Tuomilehto, J., Swift, Amy J, Uiterwaal, C. S. P. M., Taylor, Herman A, Munroe, Patricia B, Serge Hercberg, Morrison, Alanna C, Fadi J. Charchar, Arfan Ikram, M., Germaine C. Verwoert, Bok-Ghee Han, Sharon B. Wyatt, Soininen, Pasi, Kardia, Sharon L R, Carl D. Langefeld, Andrew A. Hicks, Farlow, D., Bis, Joshua C, Kang, Sun J., Roberto Elosua, Andre G. Uitterlinden, Curb, J. David, Ehret, G.B., Albert W. Dreisbach, Prabhakaran, D., Salomaa, V., Parsa, Afshin, Dreisbach, AW, Dries, DL, Mohlke, K.L., Campbell, Harry, Platou, C. G. P., Kinra, S., Nguyen, K.-d. H., Hirschorn, J.N., Kivimaki, Mika, Narisu, Narisu, Hingorani, A.D., Afshin Parsa, Johnson, A.D., Fabsitz, R.R., Vollenweider, P., Rasheed, Asif, Linda S. Adair, Voight, Benjamin F, Kardia, SLR, Scott, J., Cho, Y. S., Guo, X., Newton-Cheh, Christopher, Mcardle, W. L., Kuh, Diana, Leena Peltonen, Arking, D.E., McKenzie, C.A., Bochud, M., Wain, L. V., Dries, D., Plump, A., Kulkarni, Smita R, Nilsson, Peter, Meitinger, T., Doumatey, Ayo P, Ozren Polasek, Dreisbach, A., Jeanette Erdmann, Mario A. Morken, Parsa, A., Takayoshi Ohkubo, Kardia, Sharon L.R., Han, Bok-Ghee, Shrine, N. R. G., Albert V. Smith, Smith, A.V., Gonçalo R. Abecasis, Yajnik, C.S., Rosengren, A., Inga Prokopenko, David P. Strachan, Nora Franceschini, Wareham, Nicholas J, Young, J.H., Stringham, H. M., Adeyemo, A, Barroso, I., Smith, G.D., Jan A. Staessen, Kita, Y., Franceschini, N., Nalls, M. A., Vilmundur Gudnason, Tetsuro Miki, Smith, G. D., Lohman, K.K., Guangju Zhai, Young, J Hunter, Mattace-Raso, Francesco U S, Tom R. Gaunt, Alexander, Myriam, Zhu, X, Hingorani, A. D., Langefeld, C.D., Ramachandran, V.S., Lyytikäinen, Leo-Pekka, Wang, Thomas J, Doumatey, Ayo P., Bis, J.C., Wilson, J.F., Okamura, Tomonori, Myriam Alexander, Gerjan Navis, Mattace-raso, F. U. S., Raitakari, O., Rudock, Megan E, International Consortium for Blood Pressure Genome-Wide Association Studies, Connell, J. M., Feng Zhang, Adair, L. S., Beckmann, J. S., Lyytikäinen, L.P., Wong, Tien Y, Gina Hilton, E. Shyong Tai, Scott, Laura J, Peltonen, Leena, Lohman, K. K., Soranzo, N., John F. Peden, Dominiczak, A.F., Charchar, F. J., Tayo, B.O., Dreisbach, Albert W., Lawlor, D.A., Rotter, J. I., Kahonen, M., Boehnke, Michael, Ian N.M. Day, Palmas, Walter, Campbell, H., Eaton, CB, Coresh, Josef, Scott, James, Barbara Ludwig, Heather M. Stringham, Isaacs, A., O'reilly, P. F., Bergman, R. N., CARDIoGRAM consortium, [Unknown], Zitting, Paavo, Hwang, S.J., Levy, D, Wilson, James F; id_orcid, Corsi, Anna Maria, Shuldiner, A. R., O'Reilly, P.F., Lawrence, R. W., Bergmann, S., Pattaro, C., Khaw, K.-t., Stefan R. Bornstein, Collins, R., Frayling, Timothy M, Farrall, M., Teumer, Alexander, Umemura, S., Matullo, G., Martin, Lisa W, Pattaro, Cristian, Leo-Pekka Lyytikäinen, Li, Y, Ehret, Georg B., Nicole L. Glazer, Aroon D. Hingorani, Abecasis, Gonçalo R, Emilsson, Valur, Gaunt, T. R., Tomonori Okamura, Heckbert, S.R., Ming-Huei Chen, Ramachandran, V. S., Gang Shi, Wendy L. McArdle, Collins, F. S., Jutta Palmen, Nilesh J. Samani, Lakatta, Edward G, Veikko Salomaa, Townsend, R. R., Fava, C., Wang, T.J., Lawlor, D. A., Morrison, A., Chambers, J.C., Khaw, Kay-Tee, Yurii Aulchenko, Wu, Ying, Wain, L.V., Chandak, Giriraj R, Muhammad Islam, Viigimaa, M., Day, I.N., Raffel, Leslie J, Kristian Hveem, Taylor, A., Liu, Yongmei, Gerald R. Fowkes, Musani, Solomon K, Soler Artigas, Maria, Samani, Nilesh J, Sekar Kathiresan, Kardia, S.L., Musani, Solomon K., Alan B. Weder, Hirschhorn, J.N., McArdle, W.L., Vollenweider, Peter, Melander, O., Meneton, P., Cooper, J.A., Wong, T.Y., Morrison, AC, Soranzo, Nicole, Hayward, Caroline, Palmer, N. D., Albert Hofman, Ohkubo, T., O'Donnell, Chris, Zelenika, Diana, Voight, B.F., Redline, Susan, Yali Li, Igl, Wilmar, Wild, S. H., Kottgen, A., Morris J. Brown, Farlow, D.N., Iwai, Naoharu, Würz, Peter, Gieger, Christian, Yao, Jie, Kroemer, H.K., Ala-Korpela, Mika, Rotimi, C.N., Viikari, Jorma, Penman, Alan D, Caulfield, MJ, Sim, X., Simonetta Guarrera, Bonnycastle, L.L., Bakker, S. J. L., Mosley, T. H., Kranthi Kumar, M. J., Lyle J. Palmer, M.J. Kranthi Kumar, Fox, E.R., Liu, Kiang, Chakravarti, Aravinda, Fredrik Nyberg, Schwartz, S.M., John M. Connell, Kuusisto, Johanna, Wagenknecht, L.E., Morken, M.A., Adeyemo, A., Alexander Teumer, Alan R. Shuldiner, Grobbee, D. E., Morris, Richard W, Lakatta, E.G., Amin, N., Nyberg, Fredrik, Dreisbach, A.W., Oostra, B.A., Mika Kivimaki, Watkins, Hugh, Morrison, A.C., Harris, T. B., Meschia, J. F., Christian Gieger, Sijbrands, E. J. G., Bergman, Richard N, J. David Curb, Polak, Josef F., Thelle, Dag S, Morken, Mario A, Ioanna Tzoulaki, Raymond R. Townsend, Jafar, T.H., Aspelund, Thor, Polak, J.F., Michael Boehnke, Redline, S., Jackson, A. U., Viigimaa, Margus, Saleheen, Danish, Kim, H.-l., Hardy, Rebecca, Spector, T.D., Sijbrands, E.J., Forrester, T., Navis, Gerjan, Howard, P., Isaacs, Aaron, Verwoert, G.C., Rice, Kenneth M, Kathiresan, Sekar, Larson, Martin G, Tomaszewski, M., Hingorani, Aroon D, Lakatta, E. G., Markus Perola, Loos, R.J., Gyllensten, U.B., Alena Stančáková, Perola, M., Peter Nilsson, Jemma C. Hopewell, Alan D. Penman, Ruth J.F. Loos, Staessen, J. A., Ala-korpela, M., Haidong Zhu, Fabsitz, Richard R, Francesco U.S. Mattace-Raso, Musani, S.K., Abecasis, G. R., Tien Y. Wong, Aulchenko, Yurii, Robert Clarke, Maria SolerArtigas, Jafar, Tazeen H, Arora, P., Chasman, D.I., Janipalli, C. S., Karen L. Mohlke, Kangas, Antti J, Dabeeru C. Rao, Hwang, S.-j., Adair, Linda S, N. Charlotte Onland-Moret, Richard S. Cooper, Anne U. Jackson, Kulkarni, S.R., Gaunt, Tom R, Kutlar, A., Sõber, Siim, Lee, N.R., Leif Groop, Wain, Louise V, Yan V. Sun, Hopewell, J.C., Prabhakaran, Dorairajan, Palmen, J., Staessen, Jan A, Bragg-gresham, J. L., Lucas, G., Terho Lehtimäki, Nanette R. Lee, Fowkes, G. R., Tuomilehto, Jaakko, Paolo Vineis, Solerartigas, M., Richard W. Morris, Kumari, Meena, Eric J.G. Sijbrands, Eaton, C.B., Asif Rasheed, Vartiainen, E., Uda, M., Kroemer, Heyo K, Susan R. Heckbert, Connell, J.M., Ehret, GB, Eaton, Charles B., Morken, M. A., Harris, Tamara B, Kathiresan, S., O'Reilly, Paul F, Amin, Najaf, Kettunen, Johannes, Ganesh, S., Chang, Y.-p. C., H.-Erich Wichmann, Langefeld, Carl D, Elliott, Paul, Zhai, G., Siim Sõber, Dorr, M., Shi, Gang, Shrine, Nick R G, Zhu, H., Kenneth M. Rice, Humphries, S.E., Kardia, SL, Laan, Maris, J. Hunter Young, Bots, M. L., Pankaj Sharma, Vikal Tripathy, Cooper, Matthew N, Samani, N., Peter Vollenweider, Hicks, A. A., Terzic, J., Ganesh, S, Yoon Shin Cho, Ben A. Oostra, Swift, A.J., Eaton, Charles B, Schwarz, P. E. H., Manuela Uda, Matullo, Giuseppe, Sehmi, J. S., Palmer, Nicholette D, Demirkan, A., Bochud, Murielle, Weder, A.B., Boerwinkle, Eric, Humphries, Steve E, Jacqueline C.M. Witteman, Beilby, J.P., Wyatt, Sharon B, Wichmann, H.E., Martin Farrall, Hveem, K., Martin D. Tobin, Paul R. Burton, Mooser, Vincent, Mohlke, K. L., Curb, J David, Cooper, M.N., Heckbert, Susan R, Eyheramendy, S., Bandinelli, S., Taylor, HA, Orru, M., Tayo, BO, Hunt, S. C., Ervin R. Fox, Aspelund, T., Liu, K, Morrison, A. C., Levy, Daniel, Tamara B. Harris, oel, Anuj, Wichmann, H-Erich, Cooper, RS, Bonnycastle, L. L., Wong, A., Taylor, H. A., Xueling Sim, Watkins, H., Charchar, F.J., Nicholette D. Palmer, Wagenknecht, L. E., Wright, Alan F, Diederick E. Grobbee, ICBP Consortium (Meitinger, T. ; Wichmann, H.-E.), Vineis, Paolo, Brown, M.J., Narisu, N., Mark J. Caulfield, Yuri Milaneschi, Ueshima, Hirotsugu, Jerome I. Rotter, Lee, J.Y., Danesh, J., Bots, Michiel L, Sanjay Kinra, Paul M. Ridker, Campbell, Harry; id_orcid, Wiggins, K.L., Kuznetsova, Tatiana, Chandak, G.R., Chasman, Daniel I, Johnson, A. D., Peter S. Braund, Singleton, Andrew, Lehtimaki, T., Ridker, P. M., Johnson, T., Tazeen H. Jafar, ?, ?, Zhao, Jing Hua, Kao, W. H. L., O'donnell, C., Kao, Wen Hong Linda, Witteman, Jacqueline C M, Townsend, Raymond R., Martin G. Larson, Shuldiner, A.R., Rudock, M.E., Rotimi, Charles N, Mark Lathrop, Arking, Dan E, Musani, SK, Musani, S., Seshadri, S., Platou, C.G., Tzoulaki, Ioanna, Hilton, G., Fowkes, F Gerald R, Mark Seielstad, Caulfield, M. J., Wiggins, Kerri L, Uda, Manuela, John P. Beilby, Ying Wu, Guo, Xiuqing, Bandinelli, Stefania, Bakker, S.J., Prokopenko, Inga, International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Fulvio Ricceri, Dena Hernandez, Narisu Narisu, Ikram, M Arfan, Bergmann, Sven, Daniel I. Chasman, Rasheed, A., Tobin, M.D., Richard R. Fabsitz, Adair, L.S., Martin, LW, Scuteri, A., Palmen, Jutta, Adebowale Adeyemo, Abecasis, G.R., Sun J. Kang, Rao, Dabeeru C, Dreisbach, Albert W, Chittaranjan S. Yajnik, Peter Würz, Rotimi, CN, Taru Tukiainen, Ueshima, H., Wurz, P., Rotter, Jerome I, Chen, Ming-Huei, Alan F. Wright, Kang, S. J., Kuh, D., Franceschini, Nora, Andrew Wong, Goel, A., Stringham, H.M., Lyon, H. N., Marco Orru, Janipalli, C., Vincent Mooser, Curb, J. D., Fox, E., Kardia, Sharon LR, Andrew Singleton, Curb, J.D., Laakso, M., Hunt, Steven C, Dörr, Marcus, Juan P. Casas, Terzic, Janos, Erdmann, J., Arora, Pankaj, Murielle Bochud, Vasyl Pihur, Kuusisto, J., van Duijn, C.M., Philippa J. Talmud, Wagenknecht, Lynne E, Levy, D., Chambers, J. C., Parker, Alex N, Sjögren, Marketa, Simon Heath, Paavo Zitting, Fowkes, F.G., Raffel, L.J., Hirschorn, Joel N., Anders Hamsten, Bornstein, S.R., Adeyemo, Adebowale, van der Harst, Pim, Loos, R. J. F., Jafar, T. H., Sun, Yan V, Luigi Ferrucci, Ludwig, B., Corsi, A.M., Schwarz, P.E., Kähönen, Mika, Tobin, Martin D, Anuj Goel, Paul Elliott, Sun, Yan V., Mika Kähönen, Witteman, J. C. M., Jie Yao, Uitterlinden, A. G., Stefan-Martin Brand, Deloukas, P., Wang, T. J., Fox, ER, Weder, Alan B, Frayling, T. M., Dehghan, A., CKDGen consortium, [Unknown], Guarrera, Simonetta, Teumer, A., Pim van der Harst, Joban S. Sehmi, James Scott, Andrew Plump, Wareham, N. J., Sjogren, M., Beckmann, J.S., Bragg-Gresham, J.L., Kao, W.H., Kinra, Sanjay, Shuldiner, Alan R, Plump, Andrew, Daniel Levy, Polasek, O., Lohman, Kurt K, Hirschorn, J. N., Wyatt, S.B., International Consortium for Blood Pressure Genome-wide Associat, Munroe, P.B., Kita, Yoshikuni, Amy J. Swift, Kutlar, Abdullah, Wild, Sarah H; id_orcid, Jackie A. Cooper, Taylor, Andrew, Grobbee, Diederick E, Nalls, Michael A, Seielstad, M., Ayo P. Doumatey, Wu, Y., Zhang, Feng, Glazer, N. L., David Altshuler, Marmot, Michael G, Deloukas, Panos, Rosengren, Annika, Twee-hee Ong, R., Ohkubo, Takayoshi, Margus Viigimaa, O'Connell, J.R., Steinle, Nanette I, Laura J. Scott, Saleheen, D., Laitinen, Jaana, Rory Collins, Jarvelin, M.-r., Burton, P. R., Go, Min Jin, Collins, Rory, Talmud, P. J., Kim, H.L., Hofman, Albert, Zhao, J.H., Yongmei Liu +999 morecore +2 more sourcesCharting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti +21 morewiley +1 more sourceSingle‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer
Advanced Science, EarlyView.Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang +10 morewiley +1 more sourceLarge‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu +23 morewiley +1 more source
