Results 41 to 50 of about 22,489,720 (176)

Table_1_Genome-Wide Association Studies of Soybean Yield-Related Hyperspectral Reflectance Bands Using Machine Learning-Mediated Data Integration Methods.DOCX

, 2021
In conjunction with big data analysis methods, plant omics technologies have provided scientists with cost-effective and promising tools for discovering genetic architectures of complex agronomic traits using large breeding populations.
Mohsen Yoosefzadeh-Najafabadi (6917399), Istvan Rajcan (3200832), Dan Tulpan (3843934), Milad Eskandari (9972413), Sepideh Torabi (9562675)   +4 more
core   +1 more source

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program [PDF]

, 2022
Background Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases.
Raghavan, S., Lange, E., Tsao, P.S., Hunter-Zinck, H., Marouli, E., Sun, Y.V., Huffman, J.E., Pyarajan, S., Voight, B.F., Tcheandjieu, C., Cho, K., North, K.E., Lange, L.A., Assimes, T.L., Gaziano, J.M., Wilson, P.W.F., Ho, Y.-L.A., O'Donnell, C.J., Liu, C., Chang, K.-M., Zhao, H., Huang, J., Litkowski, E., Hauser, E.R.   +23 more
core   +1 more source

Human and Machine Intelligence Together Drive Drug Repurposing in Rare Diseases

Frontiers in Genetics, 2021
Repurposing is an increasingly attractive method within the field of drug development for its efficiency at identifying new therapeutic opportunities among approved drugs at greatly reduced cost and time of more traditional methods.
Anup P. Challa, Anup P. Challa, Nicole M. Zaleski, Rebecca N. Jerome, Robert R. Lavieri, Jana K. Shirey-Rice, April Barnado, Christopher J. Lindsell, David M. Aronoff, David M. Aronoff, David M. Aronoff, Leslie J. Crofford, Raymond C. Harris, T. Alp Ikizler, Ingrid A. Mayer, Kenneth J. Holroyd, Jill M. Pulley   +16 more
doaj   +1 more source

Phenome-wide significant phenotypes in MGI identified using various PRS construction strategies^a.

, 2019
Phenome-wide significant phenotypes in MGI identified using various PRS construction strategiesa.
Stephanie E. Moser (6836720), Bhramar Mukherjee (90346), Peter VandeHaar (6836696), Sarah A. Gagliano Taliun (6836708), Jonathon LeFaive (6836711), Thomas T. Klumpner (6836717), Erin O. Kaleba (6836714), Sachin Kheterpal (5538692), Robert B. Peng (6836699), Sayantan Das (1734532), Lauren J. Beesley (6836693), Stephen B. Gruber (108155), Maxwell Salvatore (6836702), Matthew Zawistowski (6836705), Lars G. Fritsche (162272), Victoria M. Blanc (6836723), Chad M. Brummett (6338336), Gonçalo R. Abecasis (36598)   +17 more
core   +1 more source

Phenome wide association (PheWAS) of disease conditions stratified by T2D status.

, 2022
Interaction between the rs9274619:A and T2D with multiple disease conditions as outcomes (combination of incidence and prevalence) was modeled while adjusting for all covariates (sex, age, age2, race, PC1-10).
Kaavya Paruchuri (13994019), Margaret Sunitha Selvaraj (13994016), Rachel Bernardo (13994025), Sara Haidermota (13994022), Stephen S. Rich (7634141), Pradeep Natarajan (819434), Gina M. Peloso (12036929)   +6 more
core   +1 more source

The extracellular matrix phenome across species

Matrix Biology Plus, 2020
Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants.
Cyril Statzer, Collin Y. Ewald
doaj   +1 more source

The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study

Frontiers in Oncology, 2022
BackgroundProstate cancer is the second most common cancer in males worldwide, and multitudes of factors have been reported to be associated with prostate cancer risk.ObjectivesWe aim to conduct the phenome-wide exposed-omics analysis of the risk factors
Dongqing Gu, Mingshuang Tang, Yutong Wang, Huijie Cui, Min Zhang, Ye Bai, Ziqian Zeng, Yunhua Tan, Xin Wang, Ben Zhang   +9 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records

BMC Medical Genomics, 2020
Background Obstructive sleep apnea (OSA) is defined by frequent episodes of reduced or complete cessation of airflow during sleep and is linked to negative health outcomes.
Olivia J. Veatch, Christopher R. Bauer, Brendan T. Keenan, Navya S. Josyula, Diego R. Mazzotti, Kanika Bagai, Beth A. Malow, Janet D. Robishaw, Allan I. Pack, Sarah A. Pendergrass   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source