Results 61 to 70 of about 197,703 (204)
Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population
Frontiers in Genetics, 2021 Clinical conditions correlated with elevated triglyceride levels are well-known: coronary heart disease, hypertension, and diabetes. Underlying genetic and phenotypic mechanisms are not fully understood, partially due to lack of coordinated genotypic ...Robert W. Read, Karen A. Schlauch, Vincent C. Lombardi, Elizabeth T. Cirulli, Nicole L. Washington, James T. Lu, Joseph J. Grzymski, Joseph J. Grzymski +7 moredoaj +1 more sourceCADM2 is implicated in impulsive personality traits by genome- and phenome-wide association studies in humans, with further support from studies of Cadm2 mutant mice
medRxiv, 2022 Background: Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology.S. Sanchez-Roige, M. Jennings, H. Thorpe, Jazlene E. Mallari, Lieke C van der Werf, S. B. Bianchi, C. Lee, T. Mallard, S. Barnes, Jin Wu, A. Barkley-Levenson, E. Boussaty, Cedric Snethlage, Zeljana Babic, B. Winters, Katherine E Watters, T. Biederer, J. Mackillop, D. Stephens, S. Elson, P. Fontanillas, J. Khokhar, J. Young, A. Palmer +23 moresemanticscholar +1 more sourcePolygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome [PDF]
Translational Psychiatry, 2022 AbstractTourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank ...Jain, Pritesh, Miller-Fleming, Tyne, Topaloudi, Apostolia, Yu, Dongmei, Drineas, Petros, Georgitsi, Marianthi, Yang, Zhiyu, Rizzo, Renata, Müller-Vahl, Kirsten, Tumer, Zeynep, Mol Debes, Nanette, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Mir, Pablo, Cath, Danielle, Boomsma, Dorret, Roessner, Veit, Wolanczyk, Tomasz, Janik, Piotr, Szejko, Natalia, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Buxbaum, Joseph, Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Benaroya-Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Morer, Astrid, Mueller, Norbert, Munchau, Alexander, Plessen, Kerstin, Porcelli, Cesare, Walitza, Susanne, Schrag, Anette, Martino, Davide, Als, Thomas, Aschauer, Harald, Atzmon, Gil, Bækvad-Hansen, Matie, Barta, Csaba, Barr, Cathy, Barzilai, Nir, Batterson, James, Batterson, Robert, Benarroch, Fortu, Berlin, Cheston, Boberg, Julia, Bodmer, Benjamin, Bohnenpoll, Julia, Børglum, Anders, Brown, Lawrence, Bruun, Ruth, Budman, Cathy, Buckner, Randy, Buxbaum, Joseph, Bybjerg-Grauholm, Jonas, Cath, Danielle, Cheon, Keun-Ah, Chouinard, Sylvain, Coffey, Barbara, Coppola, Giovanni, Crowley, James, Dahl, Niklas, Davis, Lea, Darrow, Sabrina, Daly, Mark, Depienne, Christel, De Rubeis, Silvia, Dietrich, Andrea, Dion, Yves, Djurfeldt, Diana, Domenech-Salgado, Laura, Eapen, Valsamma, Elzerman, Lonneke, Fernandez, Thomas, Freimer Carolin Fremer, Nelson, Garcia-Delgar, Blanca, Garrido, Marcos, Gilbert, Donald, Giusti-Rodriguez, Paola, Grados, Marco, Greenberg, Erica, Grove, Jakob, Grice, Dorothy, Hagstrom, Julie, Halvorsen, Matt, Hartmann, Andreas, Hansen, Bjarne, Haavik, Jan, Hebebrand, Johannes, Heiman, Gary, Herrera, Luis, Heyman, Isobel, Hinney, Anke, Hirschtritt, Matthew, Hoekstra, Pieter, Sul, Jae, Hong, Hyun, Hougaard, David, Huang, Alden, Ibanez-Gomez, Laura, Ivankovic, Franjo, Jankovic, Joseph, Karlsson, Elinor, Kaprio, Jakko, Kim, Young, Kim, Young-Shin, King, Robert, Knowles, James, Koh, Yun-Joo, Kook, Sodham, Khalifa, Najah, Konstantinidis, Anastasios, Kuperman, Samuel, Kurlan, Roger, Kvale, Gerd, Leckman, James, Lee, Paul, Leventhal, Bennett, Lichtenstein, Paul, Lindbald-Toh, Kerstin, Lowe, Thomas, Ludolph, Andrea, da Silva, Claudia, Luðvigsson, Pétur, Luykx, Jurjen, Lyon, Gholson, Mahjani, Behrang, Maras, Athanasios, Mataix-Cols, David, Mattheisen, Manuel, Mathews, Carol, Malaty, Irene, Mcmahon, William, Mcquillin, Andrew, Meier, Sandra, Miller-Fleming, Tyne, Mir, Pablo, Moessner, Rainald, Morer, Astrid, Mortensen, Preben, Mors, Ole, Mudgal, Poorva, Muller-Vahl, Kirsten, Munchau, Alexander, Nagy, Peter, Naarden, Allan, Neale, Benjamin, Nawaz, Muhammad, Nissen, Judith, Nöthen Merete Nordentoft, Markus, Nordsletten, Ashley, Okun, Michael, Ophoff, Roel, Osiecki, Lisa, Palotie, Aarno, Palviainen, Teemu, Paschou, Peristera, Pato Michele T. Pato, Carlos, Pittenger, Christopher, Plessen, Kerstin, Pollak, Yehuda, Posthuma, Danielle, Ramos, Eliana, Reichert, Jennifer, Rizzo, Renata, Robertson, Mary, Roessner, Veit, Roffman, Joshua, Rouleau, Guy, Rück, Christian, Sæmundsen, Evald, Samuels, Jack, Sandin, Sven, Sandor, Paul, Schlögelhofer, Monika, Scharf, Jeremiah, Shin, Eun-Young, Singer, Harvey, Smit, Jan, Smoller, Jordan, State, Matthew, Solem, Stian, Song, Dong-Ho, Song, Jungeun, Stamenkovic, Mara, Stefansson, Hreinn, Stefansson, Kári, Strom, Nora, Stuhrmann, Manfred, Szatkiewicz, Jin, Szymanska, Urszula, Aranyi, Tamas, Pagliaroli, Luca, Mathews, Carol +202 moreopenaire +12 more sourcesA phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Nature Communications, 2020 Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed Xueyi Shen, David M. Howard, Mark J. Adams, W. David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh +8 moredoaj +1 more sourceGenetic regulation of mouse liver metabolite levels. [PDF]
, 2014 We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...Bennett, Brian J, Che, Nam, Ghazalpour, Anatole, Hagopian, Raffi, He, Aiqing, Kayne, Paul, Kirchgessner, Todd, Lusis, Aldons J, Orozco, Luz, Pan, Calvin, Shih, Diana, Yang, Wen-pin +11 morecore +1 more sourcePhenome-Wide Association Study of Actigraphy in the UK Biobank [PDF]
, 2021 AbstractWrist-worn accelerometer actigraphy devices present the opportunity for large-scale data collection from people during their daily lives. Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and validation cohorts with a ...Thomas G. Brooks, Nicholas F. Lahens, Gregory R. Grant, Yvette I. Sheline, Garret A. FitzGerald, Carsten Skarke +5 moreopenaire +1 more sourceTHE TREND TOWARDS PHENOME-WIDE ASSOCIATION STUDIES (PheWASs) IN COVID-19 RESEARCH [PDF]
SOUTHERN JOURNAL OF SCIENCES, 2022 Background: Coronavirus Disease-2019 (COVID-19) appears in individuals asymptomatically and in various symptomatic forms. Symptomatic diversity can result in diagnosis failures, hospitalization, admission to intensive care, multi-organ failure, and death. The causes and risk factors of the severity of disease symptoms are uncertain.Atçeken, Nazente, Kozalak, Gül, Ozgul, Rıza Köksal, Syed, Hamzah +3 moreopenaire +1 more sourceThe epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]
, 2015 Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and Corley, Janie, Cox, Simon R, Deary, Ian J, Gibson, Jude, Harris, Sarah E, Horvath, Steve, Marioni, Riccardo E, McRae, Allan F, Muniz-Terrera, Graciela, Murphy, Lee, Pattie, Alison, Redmond, Paul, Ritchie, Stuart J, Shah, Sonia, Starr, John M, Taylor, Adele, Visscher, Peter M, Wray, Naomi R +17 morecore +1 more source
