Results 81 to 90 of about 10,755 (158)

Genetic insights into cardiac conduction disorders from genome-wide association studies

Human Genomics
Background Substantial data support a heritable basis for cardiac conduction disorders (CCDs), but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood, therefore, we sought to identify genetic loci associated with
Bingxun Li, Hongxuan Xu, Lin Wu
doaj   +1 more source

Genome–phenome association prediction using weighted deep matrix factorization with a multisource graph attention network

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Genome–phenome association (GPA) prediction can broaden the understanding of biological mechanisms underlying complex phenotypic traits (e.g., diseases and agronomic traits). Traditional deep matrix factorization (DMF)‐based GPA methods can integrate multiple data types and uncover nonlinear associations but often rely on low‐dimensional ...
Ran Duan, Wei Cao, Maozu Guo, Le Tian, Lingling Zhao   +4 more
wiley   +1 more source

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source

Body Mass Index and Risks of More Than 40 Cause‐Specific Mortality in Chinese Women: A Prospective Cohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The health consequences of being underweight are less well‐studied than obesity. We aimed to examine the association between body mass index (BMI) and mortality from a wide range of diseases across the full BMI spectrum, with particular focus on how low BMI may affect premature and nonpremature death.
Jingcen Hu, Yalei Ke, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Xiaoyu Chang, Maxim Barnard, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, China Kadoorie Biobank Collaborative Group   +15 more
wiley   +1 more source

Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci

Frontiers in Immunology
BackgroundDespite extensive genetic studies investigating primary biliary cholangitis (PBC), the mechanistic basis of risk-associated variants remains poorly understood.
Min Zhang, Liang Lyu, Liang Lyu, Liang Ge, Yizhou Wang, Dongqing Gu   +5 more
doaj   +1 more source

Symptom Flares in Endometriosis: Burden, Self‐Management and Barriers to Care in a Cross‐Sectional Survey

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 9, Page 1731-1741, August 2026.
ABSTRACT Objective To explore the characteristics of symptom flares, individual experiences and behaviours during flares in people with endometriosis. Design Online questionnaire shared on patient support sites. Setting People with a confirmed or working diagnosis of endometriosis (a working diagnosis is given by clinicians based on symptoms/history ...
Lydia Coxon, Emma Evans, Francine Toye, Emma Cox, Katy Vincent   +4 more
wiley   +1 more source

Air pollution and human health: a phenome-wide association study

BMJ Open
Objectives To explore the associations of long-term exposure to air pollution with onset of all human health conditions. Design Prospective phenome-wide association study.
Emilie Rune Hegelund, Amar J Mehta, Zorana J Andersen, Youn-Hee Lim, Steffen Loft, Bert Brunekreef, Gerard Hoek, Kees de Hoogh, Laust Hvas Mortensen   +8 more
openaire   +5 more sources

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank.

PLoS ONE, 2019
The Estonian Biobank, governed by the Institute of Genomics at the University of Tartu (Biobank), has stored genetic material/DNA and continuously collected data since 2002 on a total of 52,274 individuals representing ~5% of the Estonian adult ...
Glen James, Sulev Reisberg, Kaido Lepik, Nicholas Galwey, Paul Avillach, Liis Kolberg, Reedik Mägi, Tõnu Esko, Myriam Alexander, Dawn Waterworth, A Katrina Loomis, Jaak Vilo   +11 more
doaj   +1 more source

Genetic and Epigenetic Studies in Diabetic Kidney Disease

Frontiers in Genetics, 2019
Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular complication and occurs in 30–40% of diabetes patients.
Harvest F. Gu
doaj   +1 more source

Multiancestry and Multitrait GWAS Meta‐Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
This study integrated GWAS data for schizophrenia from European (PGC, FinnGen, iPSYCH) and East Asian cohorts with GWAS of chronic pulmonary diseases (COPD, asthma, ILD, pneumonia) and lung function traits, alongside transcriptomic and proteomic datasets (GEO, GTEx, CommonMind, pQTL).
Abudusalamu Ayoufu, Ayinigeer Abulimiti, Wusimanjiang Aierken, ZhouBin Wei, XueCheng Wang, HaiFeng Wang, Liang Zhao   +6 more
wiley   +1 more source