Results 81 to 90 of about 197,703 (204)

Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10 [PDF]

, 2017
Acknowledgments The authors wish to acknowledge technical assistance from Mrs. Indrė Libnickienė and intellectual input from Dr. David A. Blizard. This research was funded by the European Social Fund under the Global Grant measure. Grant VP1-3.1-ŠMM-07-K-
Fokin, Andrej, Kvedaras, Mindaugas, Lionikas, Arimantas, Minderis, Petras, Ratkevicius, Aivaras, Venckunas, Tomas   +5 more
core   +1 more source

A polygenic and phenotypic risk prediction for Polycystic Ovary Syndrome evaluated by Phenome-wide association studies

bioRxiv, 2019
Purpose As many as 75% of patients with Polycystic ovary syndrome (PCOS) are estimated to be unidentified in clinical practice. Utilizing polygenic risk prediction, we aim to identify the phenome-wide comorbidity patterns characteristic of PCOS to ...
Yoonjung Yoonie Joo, Ky’Era V. Actkins, J. Pacheco, A. Basile, R. Carroll, D. Crosslin, F. Day, J. Denny, D. V. Velez Edwards, H. Hakonarson, J. Harley, S. Hebbring, Kevin Ho, G. Jarvik, Michelle R Jones, T. Karaderi, F. Mentch, C. Meun, B. Namjou, S. Pendergrass, M. Ritchie, I. Stanaway, M. Urbanek, Theresa L. Walunas, Maureen E. Smith, R. Chisholm, A. Kho, L. Davis, M. Hayes, F. Day, T. Karaderi, Michelle R Jones, C. Meun, Chunyan He, A. Drong, P. Kraft, N. Lin, Hongyan Huang, L. Broer, R. Magi, R. Saxena, T. Laisk-Podar, M. Urbanek, M. Hayes, G. Thorleifsson, J. Fernández-Tajes, A. Mahajan, B. Mullin, B. Stuckey, T. Spector, Scott G Wilson, M. Goodarzi, L. Davis, Barbara Obermeyer-Pietsch, A. Uitterlinden, V. Anttila, B. Neale, M. Jarvelin, B. Fauser, I. Kowalska, J. Visser, Marianne Anderson, K. Ong, E. Stener-Victorin, D. Ehrmann, R. Legro, A. Salumets, M. McCarthy, L. Morin-Papunen, U. Thorsteinsdóttir, K. Stefánsson, U. Styrkársdóttir, J. Perry, A. Dunaif, J. Laven, S. Franks, C. Lindgren, C. Welt   +77 more
semanticscholar   +1 more source

Efficient Replication of Over 180 Genetic Associations with Self-Reported Medical Data [PDF]

, 2011
While the cost and speed of generating genomic data have come down dramatically in recent years, the slow pace of collecting medical data for large cohorts continues to hamper genetic research. Here we evaluate a novel online framework for amassing large
Joyce Y. Tung, Chuong B. Do, David A. Hinds, Amy K. Kiefer, J. Michael Macpherson, Arnab B. Chowdry, Uta Francke, Brian T. Naughton, Joanna L. Mountain, Anne Wojcicki, Nicholas Eriksson   +10 more
core   +7 more sources

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration [PDF]

, 2015
Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls.
A Apt, A Götz, A Zumla, AJ Wolf, AJ Wolf, Ali Alisaac, B Howie, B Howie, BN Howie, Changxin Wu, Christian G Meyer, D Lin, DA Murphy, Delphine Cuchet-Lourenço, Emma Stebbings, ER Chimusa, F Zhang, FR Zhang, Francis Drobniewski, Helen L Zenner, Ingelore Baessmann, J Marchini, James Curtis, JB Maller, JD Ernst, Jeffrey C Barrett, Jimmy Z Liu, JM Korn, JP Ehlers, JS Szeszko, Kitty Lo, L Jostins, LB Barreiro, Liliya Kopanitsa, LL Roberts, M Möller, Mailis Maes, Olga Ignatyeva, PA Randazzo, Peter Nürnberg, PL Lin, Rolf D Horstmann, S Bharti, Sergey Nejentsev, T Müller, T Thye, T Thye, Thorsten Thye, Vincent Plagnol, Vladyslav Nikolayevskyy, Y Onodera, Yang Luo, Yanina Balabanova, Z Nie   +53 more
core   +3 more sources

Air pollution and human health: a phenome-wide association study [PDF]

BMJ Open
Objectives To explore the associations of long-term exposure to air pollution with onset of all human health conditions. Design Prospective phenome-wide association study.
Emilie Rune Hegelund, Amar J Mehta, Zorana J Andersen, Youn-Hee Lim, Steffen Loft, Bert Brunekreef, Gerard Hoek, Kees de Hoogh, Laust Hvas Mortensen   +8 more
openaire   +4 more sources

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

Genome Medicine, 2018
Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear.
Junfei Zhao, Feixiong Cheng, Peilin Jia, Nancy Cox, Joshua C. Denny, Zhongming Zhao   +5 more
doaj   +1 more source

Prevalence and associated factors of skin cancer in aged nursing home residents: A multicenter prevalence study [PDF]

, 2019
Non-melanoma-skin cancer is an emerging clinical problem in the elderly, fair skinned population which predominantly affects patients aged older than 70 years.
Akdeniz, Merve, Blume-Peytavi, Ulrike, Hahnel, Elisabeth, Kottner, Jan, Ulrich, Claas   +4 more
core   +1 more source