Results 81 to 90 of about 22,489,720 (176)

Phylogenomic analysis of ultraconserved elements clarifies relationships and morphological evolution in Cryptoplacoidea (Mollusca: Polyplacophora)

Cladistics, EarlyView.
Abstract Targeted enrichment of ultraconserved elements (UCEs) is a powerful tool for resolving phylogeny in groups with limited morphological or molecular data. Here, we use UCEs to reconstruct the first comprehensive phylogeny of the chiton superfamily Cryptoplacoidea, including museum material up to 133 years old.
Katarzyna Vončina, Zeyuan Chen, Enrico Schwabe, Anna K. Hundsdoerfer, Julia D. Sigwart   +4 more
wiley   +1 more source

Genetic insights into cardiac conduction disorders from genome-wide association studies

Human Genomics
Background Substantial data support a heritable basis for cardiac conduction disorders (CCDs), but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood, therefore, we sought to identify genetic loci associated with
Bingxun Li, Hongxuan Xu, Lin Wu
doaj   +1 more source

Supplemental material for Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus

, 2018
Supplemental Material for Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus by A. Barnado, R.J. Carroll, C. Casey, L. Wheless, J.C. Denny and L.J.
J.C. Denny (6012626), L.J. Crofford (6012629), R.J. Carroll (6012617), L. Wheless (6012623), A. Barnado (6012614), C. Casey (6012620)   +5 more
core   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source

Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci

Frontiers in Immunology
BackgroundDespite extensive genetic studies investigating primary biliary cholangitis (PBC), the mechanistic basis of risk-associated variants remains poorly understood.
Min Zhang, Liang Lyu, Liang Lyu, Liang Ge, Yizhou Wang, Dongqing Gu   +5 more
doaj   +1 more source

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv, Yanyan Liu, Bingyang Zhang, Ranran Shen, Maosong Yu, Yongyang Wu, Wanting Du, Xinru Yuan, Congwei Sun, Yan Yan, Wei Chen, Feng Chen   +11 more
wiley   +1 more source

Integrated Analysis of Grapevine Responses to Winter Pruning Reveals Temperature‐Associated, Polyphenol‐Rich Xylem Occlusions

Plant, Cell &Environment, EarlyView.
ABSTRACT Perennial crops are continually wounded throughout cultivation. To limit pathogen infection and tissue dehydration, plants have evolved a range of wound responses that protect damaged tissues. These responses include changes in gene expression and the synthesis of protective compounds such as polyphenols.
Marilou Camboué, Monica Galar‐Martínez, Grégoire Loupit, Paraskevi Charalambous, Enric Zehraoui, Joseph Tran, Josep Valls Fonayet, Luis Gonzaga Santesteban, Notburga Gierlinger, Sarah Jane Cookson   +9 more
wiley   +1 more source

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

Phenome Wide Association Studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

Frontiers in Genetics, 2014
Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations.
Robert Michael Cronin, Julie R Field, Yuki eBradford, Christian M Shaffer, Robert J Carroll, Jonathan D Mosley, Lisa eBastarache, Todd L Edwards, Scott J Hebbring, Simon eLin, Lucia A Hindorff, Paul K Crane, Sarah ePendergrass, Marylyn D Ritchie, Dana C Crawford, Jyotishman ePathak, Suzette eBielinski, David S Carrell, David R Crosslin, David H Ledbetter, David J Carey, Gerard eTromp, Marc S Williams, Eric B Larson, Gail P Jarvik, Peggy L Peissig, Murray H Brilliant, Catherine Anne McCarty, Christopher G Chute, Iftikhar J Kullo, Erwin eBottinger, Rex eChisholm, Maureen E Smith, Dan M Roden, Joshua C Denny   +34 more
doaj   +1 more source