Results 91 to 100 of about 22,489,720 (176)

Phenome-wide association studies on cardiovascular health and fatty acids considering phenotype quality control practices for epidemiological data

open access: yes, 2019
Phenome-wide association studies (PheWAS) allow agnostic investigation of common genetic variants in relation to a variety of phenotypes but preserving the power of PheWAS requires careful phenotypic quality control (QC) procedures.
Xi He   +13 more
core   +1 more source

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. [PDF]

open access: yes, 2011
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA.
Keating, BJ   +999 more
core   +2 more sources

Genetic and Epigenetic Studies in Diabetic Kidney Disease

open access: yesFrontiers in Genetics, 2019
Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular complication and occurs in 30–40% of diabetes patients.
Harvest F. Gu
doaj   +1 more source

Multi‐Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single‐Trait GWAS

open access: yesGenetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT High blood pressure (BP) represents a major cause of life‐threatening cardiovascular conditions. GWAS have identified >2000 BP‐associated signals. BP‐GWAS usually analyze each BP trait individually. However, multi‐trait GWAS may yield novel loci and improve polygenic risk scores (PRS) prediction. We explored whether multi‐trait BP‐GWAS can: (i)
Yujia Ma   +21 more
wiley   +1 more source

CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits

open access: yesFrontiers in Genetics, 2019
While genome-wide association studies are an established method of identifying genetic variants associated with disease, environment-wide association studies (EWAS) highlight the contribution of nongenetic components to complex phenotypes.
Anastasia M. Lucas   +9 more
doaj   +1 more source

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits

open access: yes, 2020
Over the recent decades, genome-wide association studies (GWAS) have dramatically changed the understanding of human genetics. A recent genetic data release by UK Biobank (UKB) has allowed many researchers worldwide to have comprehensive look into the ...
Shikov, Anton E   +3 more
core   +1 more source

Root trait dynamics of historical canola varieties under low and high nitrogen supply

open access: yesThe Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley   +1 more source

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank.

open access: yesPLoS ONE, 2019
The Estonian Biobank, governed by the Institute of Genomics at the University of Tartu (Biobank), has stored genetic material/DNA and continuously collected data since 2002 on a total of 52,274 individuals representing ~5% of the Estonian adult ...
Glen James   +11 more
doaj   +1 more source

Affordable Phenomics special topic—Foreword for The Plant Phenome Journal

open access: yesThe Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract The Affordable Phenomics special topic in The Plant Phenome Journal showcased recent advances that expand the accessibility, cost‐effectiveness, and scalability of plant phenotyping technologies. This collection of 15 articles presented innovative approaches, ranging from low‐cost sensors and open‐source analytical pipelines to artificial ...
Valerio Hoyos‐Villegas   +1 more
wiley   +1 more source

Additional file 15 of Genome-wide association studies of missing metabolite measures from two population-based studies

open access: yes
Additional file 15: Table S14.
Diana van Heemst (28182)   +12 more
core   +1 more source

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