Results 91 to 100 of about 197,703 (204)

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

From the principles of genomic data sharing to the practices of data access committees [PDF]

, 2015
Sharing genomic research data through controlled-access databases has increased in recent years. Policymakers and funding organizations endorse genomic data sharing in order to optimize the use of public funds and to increase the statistical power of ...
Borry, Pascal, Knoppers, Bartha Maria, Shabani, Mahsa   +2 more
core   +1 more source

An analytic framework for exploring sampling and observation process biases in genome and phenome‐wide association studies using electronic health records

Statistics in Medicine, 2020
Large‐scale association analyses based on observational health care databases such as electronic health records have been a topic of increasing interest in the scientific community.
Lauren J. Beesley, L. Fritsche, B. Mukherjee   +2 more
semanticscholar   +1 more source

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research, EarlyView.
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the National Health and Nutrition Examination Survey (NHANES), UK
Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang   +11 more
wiley   +1 more source

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Genome Medicine, 2021
Background Deletions and duplications of the multigenic 16p11.2 and 22q11.2 copy number variant (CNV) regions are associated with brain-related disorders including schizophrenia, intellectual disability, obesity, bipolar disorder, and autism spectrum ...
Mikhail Vysotskiy, Xue Zhong, Tyne W. Miller-Fleming, Dan Zhou, Autism Working Group of the Psychiatric Genomics Consortium^, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium^, Schizophrenia Working Group of the Psychiatric Genomics Consortium^, Nancy J. Cox, Lauren A. Weiss   +8 more
doaj   +1 more source

Analysis of HLA Variants and Graves’ Disease and Its Comorbidities Using a High Resolution Imputation System to Examine Electronic Medical Health Records

Frontiers in Endocrinology, 2022
Hyperthyroidism is a prevalent endocrine disorder, and genetics play a major role in the development of thyroid-associated diseases. In particular, the inheritance of HLA has been demonstrated to induce the highest susceptibility to Graves’ disease (GD).
Wen-Ling Liao, Wen-Ling Liao, Ting-Yuan Liu, Chi-Fung Cheng, Yu-Pao Chou, Yu-Pao Chou, Tzu-Yuan Wang, Ya-Wen Chang, Ya-Wen Chang, Shih-Yin Chen, Shih-Yin Chen, Fuu-Jen Tsai, Fuu-Jen Tsai   +12 more
doaj   +1 more source

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Genetic variation in the HLA region is associated with susceptibility to herpes zoster. [PDF]

, 2015
Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as
Armstrong, G, Baldwin, E, Borthwick, KM, Bottinger, E, Burt, A, Carlson, CS, Carrell, DS, Carroll, RJ, Comstock, BA, Crane, PK, Crawford, DC, Crosslin, DR, de Andrade, M, Denny, JC, Doheny, KF, Hanna, DS, Harley, JB, Hayes, MG, Jarvik, GP, Keating, B, Kho, A, Kim, DS, Kuivaniemi, H, Kullo, IJ, Larson, EB, Li, R, McCarty, CA, Mirel, DB, Mukherjee, S, Pacheco, J, Peissig, PL, Pugh, E, Ritchie, MD, Stallings, S, Tromp, G, Underwood, JG, Verma, SS   +36 more
core  

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

BMC Medicine, 2023
Abstract Background Endometriosis affects 1 in 9 women, yet it is poorly understood with long diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the presence of endometrial-like tissue outside of the uterus, its main symptoms are pain and infertility.
Isabelle M. McGrath, International Endometriosis Genetics Consortium, Grant W. Montgomery, Sally Mortlock   +3 more
openaire   +4 more sources