Results 91 to 100 of about 10,755 (158)

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits

Frontiers in Genetics, 2019
While genome-wide association studies are an established method of identifying genetic variants associated with disease, environment-wide association studies (EWAS) highlight the contribution of nongenetic components to complex phenotypes.
Anastasia M. Lucas, Nicole E. Palmiero, John McGuigan, Kristin Passero, Kristin Passero, Jiayan Zhou, Deven Orie, Marylyn D. Ritchie, Molly A. Hall, Molly A. Hall   +9 more
doaj   +1 more source

Evaluating the Quality and Impact of Online Patient Forums in Genomic Data Governance

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Background There is consensus that patients' perspectives should be considered in decisions about health data. Deliberative forums (DFs) have become a common tool for patient involvement (PI) in health policy development. However, translating deliberative outcomes into policy decisions poses challenges.
Apondo Eric, Schickhardt Christoph, Andrea Züger, Eva C. Winkler, Mehlis Katja   +4 more
wiley   +1 more source

Phenome Wide Association Studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

Frontiers in Genetics, 2014
Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations.
Robert Michael Cronin, Julie R Field, Yuki eBradford, Christian M Shaffer, Robert J Carroll, Jonathan D Mosley, Lisa eBastarache, Todd L Edwards, Scott J Hebbring, Simon eLin, Lucia A Hindorff, Paul K Crane, Sarah ePendergrass, Marylyn D Ritchie, Dana C Crawford, Jyotishman ePathak, Suzette eBielinski, David S Carrell, David R Crosslin, David H Ledbetter, David J Carey, Gerard eTromp, Marc S Williams, Eric B Larson, Gail P Jarvik, Peggy L Peissig, Murray H Brilliant, Catherine Anne McCarty, Christopher G Chute, Iftikhar J Kullo, Erwin eBottinger, Rex eChisholm, Maureen E Smith, Dan M Roden, Joshua C Denny   +34 more
doaj   +1 more source

Acute capillary blood DNA methylation responses to swimming exercise in high‐performance male and female swimmers

Experimental Physiology, Volume 111, Issue 8, Page 3648-3666, 1 August 2026.
Abstract Epigenetic markers, particularly DNA methylation, are promising tools for monitoring athlete health and training due to their role in cellular regulation, exercise responsiveness and molecular stability. However, exercise‐induced epigenetic changes in peripheral blood in trained individuals remain unexplored.
C. D. Goldsmith, N. G. Lawler, D. B. Pyne, M. Kozlovskaia, K. McGibbon, L. J. G. Mitchell, A. D. Govus   +6 more
wiley   +1 more source

Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

PLoS Genetics
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations.
Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, Geetha Chittoor, Hung-Hsin Chen, Rashedeh Roshani, Alyssa Scartozzi, Rachel R Dickerson, Roelof A J Smit, Michael H Preuss, Nathalie Chami, Benjamin S Hadad, Esteban J Parra, Miguel Cruz, Qin Hui, Peter W F Wilson, Yan V Sun, Xiaoyu Zhang, Gregorio V Linchangco, Sharon L R Kardia, Jessica D Faul, David R Weir, Lawrence F Bielak, Heather M Highland, Kristin L Young, Baiyu Qi, Yujie Wang, Myriam Fornage, Christopher Haiman, Iona Cheng, Ulrike Peters, Charles Kooperberg, Steven Buyske, Joseph B McCormick, Susan P Fisher-Hoch, Frida Lona-Durazo, Jesus Peralta, Jamie Gomez-Zamudio, Stephen S Rich, Kendra R Ferrier, Ethan M Lange, Christopher R Gignoux, Eimear E Kenny, Genevieve L Wojcik, Kelly Cho, Michael J Gaziano, Luc Djousse, Shuwei Liu, Dhananjay Vaidya, Renée de Mutsert, Navya S Josyula, Christopher R Bauer, Wei Zhao, Ryan W Walker, Jennifer A Smith, Leslie A Lange, Mariah C Meyer, Ching-Ti Liu, Lisa R Yanek, Miryoung Lee, Laura M Raffield, Ruth J F Loos, Penny Gordon-Larsen, Jennifer E Below, Kari E North, Mariaelisa Graff   +65 more
doaj   +1 more source

Plasma proteins and psoriatic arthritis: a proteome-wide Mendelian randomization study

Frontiers in Immunology
BackgroundPrevious epidemiological studies have identified a correlation between serum protein levels and Psoriatic Arthritis (PsA). However, the precise nature of this relationship remains uncertain.
Heran Zhao, Heran Zhao, Yi Zhou, Ziyan Wang, Xuan Zhang, Leilei Chen, Leilei Chen, Zhinan Hong, Zhinan Hong   +8 more
doaj   +1 more source

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. [PDF]

Transl Psychiatry, 2023
Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA.   +26 more
europepmc   +1 more source

Genetically supported causal genes for rheumatoid arthritis: Mendelian randomization and co‐localization analyses

Rheumatology & Autoimmunity
Background Rheumatoid arthritis (RA) is a globally prevalent condition that has a significant impact on morbidity and mortality rates. As a result, there is growing interest in understanding its pathogenetic mechanisms, particularly genetic ...
Yuanyuan Niu, Fan Su, Simin Chen, Jingnan Wang, Shuoyang Zhang, Ruiru Li, Yu Kuang, Liuqin Liang, Youjun Xiao, Hanshi Xu   +9 more
doaj   +1 more source

Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm. [PDF]

PLoS One, 2023
Joo YY, Pacheco JA, Thompson WK, Rasmussen-Torvik LJ, Rasmussen LV, Lin FTJ, Andrade M, Borthwick KM, Bottinger E, Cagan A, Carrell DS, Denny JC, Ellis SB, Gottesman O, Linneman JG, Pathak J, Peissig PL, Shang N, Tromp G, Veerappan A, Smith ME, Chisholm RL, Gawron AJ, Hayes MG, Kho AN.   +24 more
europepmc   +1 more source