Results 91 to 100 of about 21,579,379 (182)

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

New Phytologist, EarlyView.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung‐Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi, Aram Hwangbo, Hun Kim, Gyung Ja Choi, Yin‐Won Lee, Dae‐Geun Song, Hokyoung Son   +15 more
wiley   +1 more source

CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits

Frontiers in Genetics, 2019
While genome-wide association studies are an established method of identifying genetic variants associated with disease, environment-wide association studies (EWAS) highlight the contribution of nongenetic components to complex phenotypes.
Anastasia M. Lucas, Nicole E. Palmiero, John McGuigan, Kristin Passero, Kristin Passero, Jiayan Zhou, Deven Orie, Marylyn D. Ritchie, Molly A. Hall, Molly A. Hall   +9 more
doaj   +1 more source

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv, Yanyan Liu, Bingyang Zhang, Ranran Shen, Maosong Yu, Yongyang Wu, Wanting Du, Xinru Yuan, Congwei Sun, Yan Yan, Wei Chen, Feng Chen   +11 more
wiley   +1 more source

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank.

PLoS ONE, 2019
The Estonian Biobank, governed by the Institute of Genomics at the University of Tartu (Biobank), has stored genetic material/DNA and continuously collected data since 2002 on a total of 52,274 individuals representing ~5% of the Estonian adult ...
Glen James, Sulev Reisberg, Kaido Lepik, Nicholas Galwey, Paul Avillach, Liis Kolberg, Reedik Mägi, Tõnu Esko, Myriam Alexander, Dawn Waterworth, A Katrina Loomis, Jaak Vilo   +11 more
doaj   +1 more source

Genetic and Epigenetic Studies in Diabetic Kidney Disease

Frontiers in Genetics, 2019
Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular complication and occurs in 30–40% of diabetes patients.
Harvest F. Gu
doaj   +1 more source

Root trait dynamics of historical canola varieties under low and high nitrogen supply

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley   +1 more source

Phenome Wide Association Studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

Frontiers in Genetics, 2014
Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations.
Robert Michael Cronin, Julie R Field, Yuki eBradford, Christian M Shaffer, Robert J Carroll, Jonathan D Mosley, Lisa eBastarache, Todd L Edwards, Scott J Hebbring, Simon eLin, Lucia A Hindorff, Paul K Crane, Sarah ePendergrass, Marylyn D Ritchie, Dana C Crawford, Jyotishman ePathak, Suzette eBielinski, David S Carrell, David R Crosslin, David H Ledbetter, David J Carey, Gerard eTromp, Marc S Williams, Eric B Larson, Gail P Jarvik, Peggy L Peissig, Murray H Brilliant, Catherine Anne McCarty, Christopher G Chute, Iftikhar J Kullo, Erwin eBottinger, Rex eChisholm, Maureen E Smith, Dan M Roden, Joshua C Denny   +34 more
doaj   +1 more source

Affordable Phenomics special topic—Foreword for The Plant Phenome Journal

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract The Affordable Phenomics special topic in The Plant Phenome Journal showcased recent advances that expand the accessibility, cost‐effectiveness, and scalability of plant phenotyping technologies. This collection of 15 articles presented innovative approaches, ranging from low‐cost sensors and open‐source analytical pipelines to artificial ...
Valerio Hoyos‐Villegas, Michael A. Gore   +1 more
wiley   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny, Rosalind A. Eeles, Eyre, S, Kote-Jarai, Zsofia, Goh, Chee L., Neal, David E., Freddie C. Hamdy, Giles, GG, Kote-Jarai, Z, Giles, Graham, Eyre, S; id_orcid, Ali Amin Al Olama, Govindasami, K, Muir, K R; id_orcid, Al Olama, AA, Guy, M, Easton, Douglas F., Giles, G G, Govindasami, Koveela, Hamdy, Freddie C., Donovan, J L, Benlloch, Sara, Chee L. Goh, Guy, Michelle, Goh, CL, Zsofia Kote‐Jarai, Muir, KR, Al Olama, Ali Amin, Al Olama, A A, Eeles, R A, Neal, D E, Hamdy, FC, Benlloch-Garcia, S, Donovan, JL, Eyre, Steve, Muir, Kenneth, Neal, DE, Sara Benlloch‐Garcia, Severi, G, Eeles, RA, David E. Neal, Steve Eyre, Orozco, Gisela, Hamdy, F C, Michelle Guy, Hamdy, Freddie, Goh, C L, Severi, Gianluca, Koveela Govindasami, Jenny L. Donovan, Kenneth R. Muir, Graham G. Giles, Easton, DF, Gianluca Severi, Orozco, G, Douglas F. Easton, Easton, D F, Gisela Orozco, Eeles, Rosalind A.   +58 more
core   +1 more source