Results 111 to 120 of about 197,703 (204)

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study

Journal of Translational Medicine
Background Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis.
Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng, Mulong Du   +9 more
doaj   +1 more source

PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses

Frontiers in Pharmacology
IntroductionBasal cell carcinoma (BCC) is the most common skin cancer, lacking reliable biomarkers or therapeutic targets for effective treatment. Genome-wide association studies (GWAS) can aid in identifying drug targets, repurposing existing drugs ...
Qiu-Ju Han, Yi-Pan Zhu, Jing Sun, Xin-Yu Ding, Xiuyu Wang, Qiang-Zhe Zhang   +5 more
doaj   +1 more source

Accelerating Genome- and Phenome-Wide Association Studies using GPUs – A case study using data from the Million Veteran Program

bioRxiv
The expansion of biobanks has significantly propelled genomic discoveries yet the sheer scale of data within these repositories poses formidable computational hurdles, particularly in handling extensive matrix operations required by prevailing ...
Alex Rodriguez, Youngdae Kim, T. Nandi, K. Keat, Rachit Kumar, Rohan Bhukar, Mitchell Conery, Molei Liu, John Hessington, Ketan Maheshwari, Drew Schmidt, E. Begoli, Georgia D. Tourassi, S. Muralidhar, Pradeep Natarajan, B. Voight, Kelly Cho, J. Gaziano, S. Damrauer, Katherine P. Liao, Wei Zhou, J. Huffman, Anurag Verma, Ravi K. Madduri   +23 more
semanticscholar   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, Volume 78, Issue 5, Page 662-669, May 2026.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, Volume 101, Issue 5, Page 1025-1035, May 2026.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

Identification of Alzheimer's disease subtypes and biomarkers from human multi‐omics data using subspace merging algorithm

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S. Johnson, Jie Zhang, Kun Huang   +5 more
wiley   +1 more source

Genetic insights into cardiac conduction disorders from genome-wide association studies

Human Genomics
Background Substantial data support a heritable basis for cardiac conduction disorders (CCDs), but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood, therefore, we sought to identify genetic loci associated with
Bingxun Li, Hongxuan Xu, Lin Wu
doaj   +1 more source

Admission Shock Index Is an Independent Predictor of In‐Hospital All‐Cause Mortality in Patients With Acute Aortic Dissection and Intramural Hematoma

Clinical Cardiology, Volume 49, Issue 5, May 2026.
An admission shock index (SI) ≥ 0.6 is a simple, rapid predictor of higher in‐hospital mortality in patients with acute aortic dissection and intramural hematoma. This early risk stratification tool is especially valuable for identifying high‐risk patients managed with conservative treatment.
Lingbin He, Yequn Chen, Cuihong Tian, Junshuang Tang, Shiwan Wu, Qiongxia Xu, Jiaxuan She, Xuerui Tan, Xin Zhang   +8 more
wiley   +1 more source

Sounds Sweet: Sound Reduplication in Brand Names Enhances Sweet Taste Expectations

Psychology &Marketing, Volume 43, Issue 5, Page 1261-1276, May 2026.
ABSTRACT The association between brand name sounds and taste perception is an emerging area of interest in marketing research. This study aims to demonstrate the role of sound‐evoked cuteness in the expectation of sweet taste. Across seven studies (including two supplementary studies), our findings revealed that sound reduplication in brand names is ...
Kosuke Motoki, Sayo Iseki, Abhishek Pathak   +2 more
wiley   +1 more source

CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits

Frontiers in Genetics, 2019
While genome-wide association studies are an established method of identifying genetic variants associated with disease, environment-wide association studies (EWAS) highlight the contribution of nongenetic components to complex phenotypes.
Anastasia M. Lucas, Nicole E. Palmiero, John McGuigan, Kristin Passero, Kristin Passero, Jiayan Zhou, Deven Orie, Marylyn D. Ritchie, Molly A. Hall, Molly A. Hall   +9 more
doaj   +1 more source