Results 121 to 130 of about 197,703 (204)

Single‐cell transcriptional consequences of leukaemogenic SETBP1 mutations

British Journal of Haematology, EarlyView.
Mi K. Trinh, Nathaniel D. Anderson, Matthew D. Young, Holly J. Whitfield, Conor Parks, Toochi Ogbonnah, Agnes Oszlanczi, Di Zhou, Emilia R. Robertson, Angus Hodder, Rebecca Thomas, Karin Straathof, Stuart Adams, Jack Bartram, Nuala Summerfield, Sam Behjati   +15 more
wiley   +1 more source

A Systematic Review to Summarize and Critically Appraise Existing Phenotype Libraries Using Electronic Health Records

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.
ABSTRACT Purpose Pharmacoepidemiology and population health studies using electronic health care records (EHRs) must define study variables through available electronic data. These variables are operationalized through phenotypes, which are a defined set of criteria used to identify specific traits or medical conditions.
Sima Mohammadi, Cori Campbell, Miriam C. J. M. Sturkenboom, Tiago A. Vaz   +3 more
wiley   +1 more source

Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci

Frontiers in Immunology
BackgroundDespite extensive genetic studies investigating primary biliary cholangitis (PBC), the mechanistic basis of risk-associated variants remains poorly understood.
Min Zhang, Liang Lyu, Liang Lyu, Liang Ge, Yizhou Wang, Dongqing Gu   +5 more
doaj   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank.

PLoS ONE, 2019
The Estonian Biobank, governed by the Institute of Genomics at the University of Tartu (Biobank), has stored genetic material/DNA and continuously collected data since 2002 on a total of 52,274 individuals representing ~5% of the Estonian adult ...
Glen James, Sulev Reisberg, Kaido Lepik, Nicholas Galwey, Paul Avillach, Liis Kolberg, Reedik Mägi, Tõnu Esko, Myriam Alexander, Dawn Waterworth, A Katrina Loomis, Jaak Vilo   +11 more
doaj   +1 more source

A MaERF110‐MaMYB308 Transcriptional Module Negatively Regulates Lignin‐Mediated Defence Against Fusarium Wilt in Banana

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2811-2825, May 2026.
ABSTRACT Fusarium wilt of banana (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc), threatens global banana production. Lignin reinforces cell walls against pathogens and lodging, yet its regulatory mechanisms in banana remain elusive. Through genome‐wide association study (GWAS) of lignin content across 184 banana accessions, we identified ...
Yuqi Li, Yulin Hu, Weijun Xiao, Liu Yan, Junting Feng, Miaomiao Cao, Yanlin Si, Jinhan Lyu, Yankun Zhao, Kai Li, Yongzan Wei, Huigang Hu, Wei Li, Peitao Lü, Wei Wang, Zhenhai Han, Jianghui Xie   +16 more
wiley   +1 more source

Genetic and Epigenetic Studies in Diabetic Kidney Disease

Frontiers in Genetics, 2019
Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular complication and occurs in 30–40% of diabetes patients.
Harvest F. Gu
doaj   +1 more source

A Super‐Pangenome for Cultivated Citrus Reveals Evolutive Features During the Allopatric Phase of Their Reticulate Evolution

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3345-3367, May 2026.
Structure of the cultivated citrus super‐pangenome. ABSTRACT The main genetic diversity observed in cultivated citrus results from a reticulate evolution involving four ancestral taxa whose radiation occurred in allopatry. In such context, GWAS analysis, genome diversity and transcriptomic studies will be significantly enhanced through pangenome ...
Gaetan Droc, Delphine Giraud, Caroline Belser, Karine Labadie, Simone Duprat, Corinne Cruaud, Benjamin Istace, Fredson Dos Santos Menezes, Edson Mario de Andrade Silva, Franck Curk, Gilles Costantino, Alexandre Soriano, Pierre Mournet, Alexis Dereeper, Maëva Miranda, Elodie Marchi, Sylvain Santoni, Raner José Santana Silva, Stéphanie Sidibe‐Bocs, François Luro, Nathalie Choisne, Florian Maumus, Barbara Hufnagel, Fabienne Micheli, Patrick Wincker, Jean‐Marc Aury, Arnaud Lemainque, Patrick Ollitrault   +27 more
wiley   +1 more source

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

Plant–Plant Competition Limits Arabidopsis Shoot Branching and Silique Production Independently of Soil Mineral Nutrients, Strigolactones and BRANCHED1

Plant, Cell &Environment, Volume 49, Issue 5, Page 2413-2429, May 2026.
ABSTRACT In natural environments, plants compete with neighbouring plants for resources such as light, water and nutrients. To detect neighbours, plants have evolved mechanisms that are poorly understood at the molecular‐genetic level. This study examined the impact of competition on the growth and reproductive success of Arabidopsis thaliana grown in ...
Jessica Thome, Laura Trimborn, Helena Waldmann, Caroline Reize, Lea Weiler‐Tersch, Christian Schenkel, Hannah Weeks, Franziska Fichtner, Anja Linstädter, Juliette de Meaux, Ute Hoecker   +10 more
wiley   +1 more source