Results 121 to 130 of about 22,489,720 (176)
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Whether glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) activation lowers Alzheimer's disease (AD) risk via peripheral metabolic improvement or direct neuroprotection remains unclear. METHODS Using blood and brain‐cortex cis‐acting expression quantitative trait loci (cis‐eQTLs) for GLP‐1R as instruments, we performed cis ...
Li Jiang +17 more
wiley +1 more source
Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population. [PDF]
Front Psychiatry, 2022 Schlauch KA +4 more
europepmc +1 more source
Predictors of Change in Severity of Self‐Injurious Behaviors in Preschool‐Aged Autistic Children
Autism Research, Volume 19, Issue 10, October 2026.ABSTRACT Self‐injurious behaviors (SIBs) affect up to 50% of autistic individuals and significantly impact quality of life and everyday functioning. Cross‐sectional studies link the presence of SIB to lower IQ, altered sensory responsivity, and poor emotion regulation, yet their effect on changes in SIB severity from early childhood to school age in ...
Joseph Boyle +9 more
wiley +1 more source
Clinical Cardiology, Volume 49, Issue 10, October 2026.Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour +5 more
wiley +1 more source
BiomedicinesBackground: At present, there are still limitations and challenges in the treatment of hyperuricemia (HUA). Mendelian randomization (MR) has been widely used to identify new therapeutic targets.
Na Chen +6 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Skeletal muscle atrophy is a pervasive complication of critical illness that worsens survival and recovery, yet remains poorly explained by current clinical or molecular markers. Methods To directly connect disease‐associated molecular states to the contractile machinery, this study combined sequential functional, transcriptomic and
Alexandra M. Winant +10 more
wiley +1 more source
N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three Lac-AA: N-Lactoyl phenylalanine
Alshafai, Mashael +9 more
core +1 more source
International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.High PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Julia Vanini +6 more
wiley +1 more source
Frontiers in GeneticsBackgroundPrevious studies have explored the role of plasma proteins on osteonecrosis. This Mendelian randomization (MR) study further assessed plasma proteins on osteonecrosis whether a causal relationship exists and provides some evidence of causality ...
Chen Meng +12 more
doaj +1 more source
Influenza and Other Respiratory Viruses, Volume 20, Issue 10, October 2026.ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although previous studies have explored genetic susceptibility to influenza infection, the genetic basis of influenza hospitalization and its relationship with respiratory diseases like COVID‐19 remain poorly understood ...
Xiao Xue +4 more
wiley +1 more source