Results 131 to 140 of about 197,703 (204)

On the Nature of the Beast: Re-Charting Political Geographies of the European Union. Swedish Society for Antropology and Geography, 2006 [PDF]

, 2006
This review paper begins with the premise that since the European Union remains a process of construction with no agreed or pre-designated end-point, its power structure is open to a diverse range of interpretations. Moreover, the apparent novelty of the
Siddaway, James D.
core  

Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data

Statistical Methods in Medical Research, 2019
Electronic medical records data are valuable resources for discovery research. They contain detailed phenotypic information on individual patients, opening opportunities for simultaneously studying multiple phenotypes. A useful tool for such simultaneous
Stephanie F Chan, B. Hejblum, Abhishek Chakrabortty, T. Cai   +3 more
semanticscholar   +1 more source

Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections

PLOS ONE
BackgroundPhenome-WideAssociation study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest. Despite their usefulness, no systematic screening of phenotypes associated withStaphylococcusaureusinfections(SAIs) has been done leaving ...
Patrick Allaire, Noha S. Elsayed, Richard L. Berg, Warren Rose, Sanjay K. Shukla   +4 more
openaire   +3 more sources

Esp Research Trends in Asian Context [PDF]

, 2015
Due to the influence of global and regional economic changes, English for Specific Purposes (ESP) plays a more vital role in English language studies worldwide, including in Asian context.
Jantaravipark, A. (Arpawan), Sa-ngiamwibool, A. (Amporn)   +1 more
core  

Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

PLoS Genetics
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations.
Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, Geetha Chittoor, Hung-Hsin Chen, Rashedeh Roshani, Alyssa Scartozzi, Rachel R Dickerson, Roelof A J Smit, Michael H Preuss, Nathalie Chami, Benjamin S Hadad, Esteban J Parra, Miguel Cruz, Qin Hui, Peter W F Wilson, Yan V Sun, Xiaoyu Zhang, Gregorio V Linchangco, Sharon L R Kardia, Jessica D Faul, David R Weir, Lawrence F Bielak, Heather M Highland, Kristin L Young, Baiyu Qi, Yujie Wang, Myriam Fornage, Christopher Haiman, Iona Cheng, Ulrike Peters, Charles Kooperberg, Steven Buyske, Joseph B McCormick, Susan P Fisher-Hoch, Frida Lona-Durazo, Jesus Peralta, Jamie Gomez-Zamudio, Stephen S Rich, Kendra R Ferrier, Ethan M Lange, Christopher R Gignoux, Eimear E Kenny, Genevieve L Wojcik, Kelly Cho, Michael J Gaziano, Luc Djousse, Shuwei Liu, Dhananjay Vaidya, Renée de Mutsert, Navya S Josyula, Christopher R Bauer, Wei Zhao, Ryan W Walker, Jennifer A Smith, Leslie A Lange, Mariah C Meyer, Ching-Ti Liu, Lisa R Yanek, Miryoung Lee, Laura M Raffield, Ruth J F Loos, Penny Gordon-Larsen, Jennifer E Below, Kari E North, Mariaelisa Graff   +65 more
doaj   +1 more source

Plasma proteins and psoriatic arthritis: a proteome-wide Mendelian randomization study

Frontiers in Immunology
BackgroundPrevious epidemiological studies have identified a correlation between serum protein levels and Psoriatic Arthritis (PsA). However, the precise nature of this relationship remains uncertain.
Heran Zhao, Heran Zhao, Yi Zhou, Ziyan Wang, Xuan Zhang, Leilei Chen, Leilei Chen, Zhinan Hong, Zhinan Hong   +8 more
doaj   +1 more source

Polygenic risk associated with post-traumatic stress disorder onset and severity. [PDF]

, 2019
Post-traumatic stress disorder (PTSD) is a psychiatric illness with a highly polygenic architecture without large effect-size common single-nucleotide polymorphisms (SNPs).
Abu-Amara, Duna, Doyle, Francis J, Flory, Janine D, Guffanti, Guia, Jett, Marti, Lori, Adriana, Marmar, Charles R, Misganaw, Burook, Mueller, Susanne, Ressler, Kerry J, SBPBC, Yehuda, Rachel   +11 more
core  

Genetically supported causal genes for rheumatoid arthritis: Mendelian randomization and co‐localization analyses

Rheumatology & Autoimmunity
Background Rheumatoid arthritis (RA) is a globally prevalent condition that has a significant impact on morbidity and mortality rates. As a result, there is growing interest in understanding its pathogenetic mechanisms, particularly genetic ...
Yuanyuan Niu, Fan Su, Simin Chen, Jingnan Wang, Shuoyang Zhang, Ruiru Li, Yu Kuang, Liuqin Liang, Youjun Xiao, Hanshi Xu   +9 more
doaj   +1 more source

Large-scale cross-ancestry genome-wide meta-analysis of serum urate

Nature Communications
Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum urate ...
Chamlee Cho, Beomsu Kim, Dan Say Kim, Mi Yeong Hwang, Injeong Shim, Minku Song, Yeong Chan Lee, Sang-Hyuk Jung, Sung Kweon Cho, Woong-Yang Park, Woojae Myung, Bong-Jo Kim, Ron Do, Hyon K. Choi, Tony R. Merriman, Young Jin Kim, Hong-Hee Won   +16 more
doaj   +1 more source

Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate

Scientific Reports
Observationally, higher basal metabolic rate (BMR) is associated with metabolism-related disorders, cancer, aging, and mortality. In this Mendelian randomization (MR) phenome-wide association study, using two-sample MR methods, we systematically and comprehensively investigated the health effects of genetically predicted BMR across the phenome sex ...
Jack C. M. Ng, C. Mary Schooling
openaire   +3 more sources