Results 141 to 150 of about 197,703 (204)

A deep learning phenome wide association study of the electrocardiogram

European Heart Journal - Digital Health
Abstract Aims Deep learning methods have shown impressive performance in detecting a range of diseases from electrocardiogram (ECG) waveforms, but the breadth of diseases that can be detected with high accuracy remains unknown, and in many cases the changes to the ECG allowing these classifications ...
John Weston Hughes, John Theurer, Milos Vukadinovic, Albert J Rogers, Sulaiman Somani, Guson Kang, Zaniar Ghazizadeh, Jack W O’Sullivan, Sneha S Jain, Bruna Gomes, Michael Salerno, Euan Ashley, James Y Zou, Marco V Perez, David Ouyang   +14 more
openaire   +1 more source

Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis

Biomedicines
Background: At present, there are still limitations and challenges in the treatment of hyperuricemia (HUA). Mendelian randomization (MR) has been widely used to identify new therapeutic targets.
Na Chen, Leilei Gong, Li Zhang, Yali Li, Yunya Bai, Dan Gao, Lan Zhang   +6 more
doaj   +1 more source

Association between genetically plasma proteins and osteonecrosis: a proteome-wide Mendelian randomization analysis

Frontiers in Genetics
BackgroundPrevious studies have explored the role of plasma proteins on osteonecrosis. This Mendelian randomization (MR) study further assessed plasma proteins on osteonecrosis whether a causal relationship exists and provides some evidence of causality ...
Chen Meng, Chen Meng, Junxiao Ren, Junxiao Ren, Honglin Gu, Hongxin Shi, Huan Luo, Huan Luo, Zhihao Wang, Zhihao Wang, Chuan Li, Chuan Li, Yongqing Xu   +12 more
doaj   +1 more source

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts

Frontiers in Genetics, 2014
Objective: We report the first pediatric specific Phenome-Wide Association Study (PheWAS) using electronic medical records (EMRs). Given the early success of PheWAS in adult populations, we investigated the feasibility of this approach in pediatric cohorts.Method: Data on 5049 samples of European ancestry were obtained from the Electronic Medical ...
Bahram eNamjou, Bahram eNamjou, Keith eMarsolo, Keith eMarsolo, Robert eCarroll, Joshua eDenny, Marylyn D Ritchie, shefali esetia, Todd eLingren, Todd eLingren, Aleksey ePorollo, Aleksey ePorollo, Aleksey ePorollo, Beth ecobb, Cassandra ePerry, Leah Claire Kottyan, Leah Claire Kottyan, Leah Claire Kottyan, Ingrid Adele Holm, Isaac eKohane, John Barker Harley, John Barker Harley, John Barker Harley, John Barker Harley   +23 more
openaire   +1 more source

Phenome-wide association study of population-differentiating genetic variants around gene ACSL1

Evolution, Medicine, and Public Health
Abstract Background and objectives Demographic dynamics and natural selection during human evolution shaped the present-day patterns of genetic variations, and geographically varying genetic factors contribute to different disease prevalences across human populations.
Shuang Yang, Houjian Cai, Kaixiong Ye
openaire   +2 more sources

Health Implications Associated with Fat-Free Mass: A Phenome-Wide Mendelian Randomization Study

Cardiorenal Medicine
Introduction: Fat-free mass (FFM) is a critical component of the human body, with implications for various diseases. Methods: We conducted a comprehensive analysis integrating a phenome-wide association study (PheWAS), a two-sample Mendelian randomization (MR) analysis, and a systematic review to investigate the associations between FFM and health ...
Yuchen Ying, Chunxia Zhang, Shanshan Wu, Shudan Wang, Jiangfang Lian, Yupin Lin, Haiwang Guan, Dihui Cai   +7 more
openaire   +3 more sources

Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study

npj Mental Health Research
Depression is associated with increased risk for a variety of medical conditions. However, the extent to which these associations reflect a causal impact of depression on medical conditions, or vice-versa, remains unresolved.
Yu Fang, Srijan Sen, Gita A. Pathak, Margit Burmeister, Leah S. Richmond-Rakerd   +4 more
doaj   +1 more source

Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy

Scientific Reports
Central serous chorioretinopathy (CSC) is a major cause of vision loss, especially in middle-aged men, and its chronic subtype can lead to legal blindness. Despite its clinical importance, the underlying mechanisms of CSC need further clarification.
Yuki Mori, Elon H. C. van Dijk, Masahiro Miyake, Yoshikatsu Hosoda, Anneke I. den Hollander, Suzanne Yzer, Akiko Miki, Li Jia Chen, Jeeyun Ahn, Ayako Takahashi, Kazuya Morino, Shin-ya Nakao, Carel B. Hoyng, Danny S. C. Ng, Ling-Ping Cen, Haoyu Chen, Tsz Kin Ng, Chi Pui Pang, Kwangsic Joo, Takehiro Sato, Yasuhiko Sakata, Atsushi Tajima, Yasuharu Tabara, The Nagahama Study Group, Kyu Hyung Park, Fumihiko Matsuda, Kenji Yamashiro, Shigeru Honda, Masao Nagasaki, Camiel J. F. Boon, Akitaka Tsujikawa   +30 more
doaj   +1 more source

A multi-omics Mendelian randomization study reveals PAM as a potential therapeutic target for type 2 diabetes

Journal of Translational Medicine
Background The progression of type 2 diabetes (T2D) is driven by pancreatic β-cell dysfunction and loss, yet current therapies fail to address this core pathophysiology. Methods We implemented an integrative pipeline combining genetic and functional data
Ming Yi, Xingrong Feng, Qiuyue Guan, Yin Liu, Yunqiang Liu, Zhiguang Su   +5 more
doaj   +1 more source

Using Biomedical Technologies to Inform Economic Modeling: Challenges and Opportunities for Improving Analysis of Environmental Policies [PDF]

Advances in biomedical technology have irrevocably jarred open the black box of human decision making, offering social scientists the potential to validate, reject, refine and redefine the individual models of resource allocation that form the foundation
Haab, Timothy C., Roe, Brian E.
core   +1 more source