Results 101 to 110 of about 10,755 (158)

Large-scale cross-ancestry genome-wide meta-analysis of serum urate

Nature Communications
Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum urate ...
Chamlee Cho, Beomsu Kim, Dan Say Kim, Mi Yeong Hwang, Injeong Shim, Minku Song, Yeong Chan Lee, Sang-Hyuk Jung, Sung Kweon Cho, Woong-Yang Park, Woojae Myung, Bong-Jo Kim, Ron Do, Hyon K. Choi, Tony R. Merriman, Young Jin Kim, Hong-Hee Won   +16 more
doaj   +1 more source

Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population. [PDF]

Front Psychiatry, 2022
Schlauch KA, Read RW, Koning SM, Neveux I, Grzymski JJ.   +4 more
europepmc   +1 more source

Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis

Biomedicines
Background: At present, there are still limitations and challenges in the treatment of hyperuricemia (HUA). Mendelian randomization (MR) has been widely used to identify new therapeutic targets.
Na Chen, Leilei Gong, Li Zhang, Yali Li, Yunya Bai, Dan Gao, Lan Zhang   +6 more
doaj   +1 more source

Association between genetically plasma proteins and osteonecrosis: a proteome-wide Mendelian randomization analysis

Frontiers in Genetics
BackgroundPrevious studies have explored the role of plasma proteins on osteonecrosis. This Mendelian randomization (MR) study further assessed plasma proteins on osteonecrosis whether a causal relationship exists and provides some evidence of causality ...
Chen Meng, Chen Meng, Junxiao Ren, Junxiao Ren, Honglin Gu, Hongxin Shi, Huan Luo, Huan Luo, Zhihao Wang, Zhihao Wang, Chuan Li, Chuan Li, Yongqing Xu   +12 more
doaj   +1 more source

A phenome-wide association study of uterine fibroids reveals a marked burden of comorbidities

Communications Medicine
Abstract Background The burden of comorbidities in those with uterine fibroids compared to those without fibroids is understudied. We performed a phenome-wide association study to systematically assess the association between fibroids and other conditions.
Elizabeth A. Jasper, Brian S. Mautz, Jacklyn N. Hellwege, Jacqueline A. Piekos, Sarah H. Jones, Yanfei Zhang, Eric S. Torstenson, Sarah A. Pendergrass, Ming Ta Michael Lee, Todd L. Edwards, Digna R. Velez Edwards   +10 more
openaire   +3 more sources

Phenome-wide association studies go large [PDF]

Nature Reviews Genetics, 2013
openaire   +1 more source

Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study

npj Mental Health Research
Depression is associated with increased risk for a variety of medical conditions. However, the extent to which these associations reflect a causal impact of depression on medical conditions, or vice-versa, remains unresolved.
Yu Fang, Srijan Sen, Gita A. Pathak, Margit Burmeister, Leah S. Richmond-Rakerd   +4 more
doaj   +1 more source

Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia. [PDF]

Cancer Epidemiol Biomarkers Prev, 2020
Semmes EC, Vijayakrishnan J, Zhang C, Hurst JH, Houlston RS, Walsh KM.   +5 more
europepmc   +1 more source

Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy

Scientific Reports
Central serous chorioretinopathy (CSC) is a major cause of vision loss, especially in middle-aged men, and its chronic subtype can lead to legal blindness. Despite its clinical importance, the underlying mechanisms of CSC need further clarification.
Yuki Mori, Elon H. C. van Dijk, Masahiro Miyake, Yoshikatsu Hosoda, Anneke I. den Hollander, Suzanne Yzer, Akiko Miki, Li Jia Chen, Jeeyun Ahn, Ayako Takahashi, Kazuya Morino, Shin-ya Nakao, Carel B. Hoyng, Danny S. C. Ng, Ling-Ping Cen, Haoyu Chen, Tsz Kin Ng, Chi Pui Pang, Kwangsic Joo, Takehiro Sato, Yasuhiko Sakata, Atsushi Tajima, Yasuharu Tabara, The Nagahama Study Group, Kyu Hyung Park, Fumihiko Matsuda, Kenji Yamashiro, Shigeru Honda, Masao Nagasaki, Camiel J. F. Boon, Akitaka Tsujikawa   +30 more
doaj   +1 more source

A multi-omics Mendelian randomization study reveals PAM as a potential therapeutic target for type 2 diabetes

Journal of Translational Medicine
Background The progression of type 2 diabetes (T2D) is driven by pancreatic β-cell dysfunction and loss, yet current therapies fail to address this core pathophysiology. Methods We implemented an integrative pipeline combining genetic and functional data
Ming Yi, Xingrong Feng, Qiuyue Guan, Yin Liu, Yunqiang Liu, Zhiguang Su   +5 more
doaj   +1 more source