Results 71 to 80 of about 22,489,720 (176)

Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study

Journal of Translational Medicine
Background Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis.
Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng, Mulong Du   +9 more
doaj   +1 more source

Disease associations depend on visit type: results from a visit-wide association study

BioData Mining, 2019
Introduction Widespread adoption of Electronic Health Records (EHR) increased the number of reported disease association studies, or Phenome-Wide Association Studies (PheWAS).
Mary Regina Boland, Snigdha Alur-Gupta, Lisa Levine, Peter Gabriel, Graciela Gonzalez-Hernandez   +4 more
doaj   +1 more source

Peritoneal Fluid‐Derived Small Extracellular Vesicle Proteins as Potential Biomarkers for Endometriosis: A Case–Control Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To demonstrate the presence of peritoneal fluid (PF)‐derived small extracellular vesicles (sEVs) in endometriosis and control samples, to characterise their protein content and to define endometriosis‐specific biomarkers within the sEV proteome. Design Case–control experimental study. Setting Academic endometriosis centre.
Hannah M. Nazri, Roman Fischer, Joel Steele, Sanjiv Manek, Kavita S. Subramaniam, Benedikt M. Kessler, Krina T. Zondervan, Thomas T. Tapmeier, Christian M. Becker   +8 more
wiley   +1 more source

Phenome-wide association study of the major histocompatibility complex region in the Korean population identifies novel association signals

, 2022
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.Human leukocyte antigen (HLA) gene variants in the major histocompatibility complex (MHC) region are associated ...
Kim, Bong-Jo, Jang, Hye-Mi, Hwang, Mi Yeong, Hong, Sang Bin, Han, Buhm, Kim, Chanwoo, Park, Hyun-Young, Kim, Young Jin, Choi, Wanson, Yoon, Kyungheon, Jung, Sunwoo, Lim, Hyunjoon, Hyunjoon Lim, Bong-Jo Kim, Buhm Han, Hye-Mi Jang, Chanwoo Kim, Sang Bin Hong, Wanson Choi, Sunwoo Jung, Young Jin Kim, Kyungheon Yoon, Hyun-Young Park, Mi Yeong Hwang   +23 more
core   +1 more source

Lower Systolic Blood Pressure in 67 Boys With Klinefelter Syndrome Compared to 1842 Healthy Danish Boys

Andrology, EarlyView.
ABSTRACT Objective Our objective was to develop age‐ and height‐specific reference ranges for blood pressure, pulse pressure and mean arterial pressure in healthy boys and to compare these to measurements in patients with Klinefelter syndrome followed longitudinally through childhood and adolescence. Design Cohort study consisting of a population‐based
Andrés Felipe Ø. Fritzbøger, Riccardo Battiston, Cecilie N. Larsen, Anna Sophie L. Kjaer, Klaus Juul, Ida M. Schmidt, Jørgen H. Petersen, Katharina M. Main, Anders Juul, Lise Aksglaede   +9 more
wiley   +1 more source

PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses

Frontiers in Pharmacology
IntroductionBasal cell carcinoma (BCC) is the most common skin cancer, lacking reliable biomarkers or therapeutic targets for effective treatment. Genome-wide association studies (GWAS) can aid in identifying drug targets, repurposing existing drugs ...
Qiu-Ju Han, Yi-Pan Zhu, Jing Sun, Xin-Yu Ding, Xiuyu Wang, Qiang-Zhe Zhang   +5 more
doaj   +1 more source

Whole‐genome and transcriptome analysis in relapsed/refractory non‐Hodgkin lymphoma: Results from a multicentre precision oncology cohort

British Journal of Haematology, EarlyView.
Summary Comprehensive genome and transcriptome profiling can inform the diagnosis, prognosis and management of relapsed/refractory (R/R) solid malignancies, yet its integration into clinical care has lagged despite strong biological rationale. We evaluated the clinical utility of whole genome and transcriptome analysis (WGTA) in 65 patients (37 ...
Kathleen Wee, Eric J. Zhao, Cassidy Clemente‐Jones, Rebecca J. Deyell, Shahrad R. Rassekh, Anita Villani, Rosemarie Venier, Daniel Sinnett, Sylvie Langlois, Thai Hoa Tran, Thomas Sontag, Stephanie Grover, Scott Davidson, Nisha Kanwar, Winnie Lo, Erin Pleasance, Laura Williamson, Yaoqing Shen, Alina S. Gerrie, Kerry J. Savage, Laurie H. Sehn, Christopher P. Venner, Marco A. Marra, Janessa Laskin, Diego Villa   +24 more
wiley   +1 more source

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy A Phenome-Wide Association Study

, 2018
This phenome-wide association study assesses clinical associations between interleukin 6 receptor ( IL6R ) single-nucleotide polyporphisms and known IL6R drug effects and whether large biobanks and genetics can be used to assess potential beneficial and ...
Huang, Jie, Sun, Jiehuan, Honerlaw, Jacqueline, Damrauer, Scott, Cai, Tianrun A, O’Donnell, Christopher J, Ho, Yuk-Lam, Hong, Chuan, Gagnon, David, Tsao, Philip, Link, Nicholas, Cho, Kelly, Schubert, Petra, Zhang, Yichi, Cai, Tianxi, Ahuja, Yuri, Sun, Yan V, Costa, Lauren, Wilson, Peter, Gaziano, J. Michael, Liao, Katherine P   +20 more
core   +1 more source

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Brain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper   +15 more
wiley   +1 more source