Results 21 to 30 of about 10,755 (158)

Phenome-wide association studies (PheWASs) for functional variants. [PDF]

Eur J Hum Genet, 2015
The genome-wide association study (GWAS) is a powerful approach for studying the genetic complexities of human disease. Unfortunately, GWASs often fail to identify clinically significant associations and describing function can be a challenge. GWAS is a phenotype-to-genotype approach.
Ye Z, Mayer J, Ivacic L, Zhou Z, He M, Schrodi SJ, Page D, Brilliant MH, Hebbring SJ.   +8 more
europepmc   +4 more sources

A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association Studies

Journal of Clinical Endocrinology and Metabolism, 2020
Lea K Davis, Digna Velez Edwards, Anubha Mahajan   +2 more
exaly   +2 more sources

Genome-Wide Association Studies of Soybean Yield-Related Hyperspectral Reflectance Bands Using Machine Learning-Mediated Data Integration Methods

Frontiers in Plant Science, 2021
In conjunction with big data analysis methods, plant omics technologies have provided scientists with cost-effective and promising tools for discovering genetic architectures of complex agronomic traits using large breeding populations.
Mohsen Yoosefzadeh-Najafabadi, Sepideh Torabi, Dan Tulpan, Istvan Rajcan, Milad Eskandari   +4 more
doaj   +1 more source

A phenome-wide association study of ABO blood groups [PDF]

BMC Medicine, 2020
Abstract Background ABO blood group is associated with differences in lifespan, cardiovascular disease, and some cancers, for reasons which are incompletely understood. To gain sex-specific additional insight about potential mechanisms driving these common conditions for future interventions, we characterized ...
Shun Li, C. M. Schooling
openaire   +3 more sources

Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative

Genome Medicine, 2022
Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health.
Ruth Johnson, Yi Ding, Vidhya Venkateswaran, Arjun Bhattacharya, Kristin Boulier, Alec Chiu, Sergey Knyazev, Tommer Schwarz, Malika Freund, Lingyu Zhan, Kathryn S. Burch, Christa Caggiano, Brian Hill, Nadav Rakocz, Brunilda Balliu, Christopher T. Denny, Jae Hoon Sul, Noah Zaitlen, Valerie A. Arboleda, Eran Halperin, Sriram Sankararaman, Manish J. Butte, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, Clara Lajonchere, Daniel H. Geschwind, Bogdan Pasaniuc   +25 more
doaj   +1 more source

Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan

Frontiers in Medicine, 2022
Excess thyroid hormones have complex metabolic effects, particularly hyperthyroidism, and are associated with various cardiovascular risk factors. Previous candidate gene studies have indicated that genetic variants may contribute to this variable ...
Ting-Yuan Liu, Ting-Yuan Liu, Wen-Ling Liao, Wen-Ling Liao, Wen-Ling Liao, Tzu-Yuan Wang, Tzu-Yuan Wang, Chia-Jung Chan, Jan-Gowth Chang, Yu-Chia Chen, Yu-Chia Chen, Hsing-Fang Lu, Hsien-Hui Yang, Shih-Yin Chen, Shih-Yin Chen, Fuu-Jen Tsai, Fuu-Jen Tsai, Fuu-Jen Tsai   +17 more
doaj   +1 more source

Phenome-Wide Association Studies: Embracing Complexity for Discovery [PDF]

Human Heredity, 2015
The inherent complexity of biological systems can be leveraged for a greater understanding of the impact of genetic architecture on outcomes, traits, and pharmacological response. The genome-wide association study (GWAS) approach has well-developed methods and relatively straight-forward methodologies; however, the bigger picture of the impact of ...
Sarah A, Pendergrass, Anurag, Verma, Anna, Okula, Molly A, Hall, Dana C, Crawford, Marylyn D, Ritchie   +5 more
openaire   +2 more sources

Phenome-wide Mendelian randomization study evaluating the association of circulating vitamin D with complex diseases

Frontiers in Nutrition, 2023
BackgroundCirculating vitamin D has been associated with multiple clinical diseases in observational studies, but the association was inconsistent due to the presence of confounders.
Jin-jian Xu, Jin-jian Xu, Xiao-bin Zhang, Wen-tao Tong, Teng Ying, Ke-qi Liu   +5 more
doaj   +1 more source

Application of clinical text data for phenome-wide association studies (PheWASs). [PDF]

Bioinformatics, 2015
Abstract Motivation: Genome-wide association studies (GWASs) are effective for describing genetic complexities of common diseases. Phenome-wide association studies (PheWASs) offer an alternative and complementary approach to GWAS using data embedded in the electronic health record (EHR) to define the phenome. International Classification
Hebbring SJ, Rastegar-Mojarad M, Ye Z, Mayer J, Jacobson C, Lin S.   +5 more
europepmc   +4 more sources

Phenome-Wide Association Study of Actigraphy in the UK Biobank [PDF]

, 2021
Abstract Wrist-worn accelerometer actigraphy devices present the opportunity for large-scale data collection from people during their daily lives. Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and ...
Thomas G. Brooks, Nicholas F. Lahens, Gregory R. Grant, Yvette I. Sheline, Garret A. FitzGerald, Carsten Skarke   +5 more
openaire   +1 more source