Results 31 to 40 of about 8,721 (232)

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Molecules, 2022
Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3 ...
Ayesha Sadiqa, Azhar Rasul, Mudassir Hassan, Salma Sultana, Farhat Jabeen   +4 more
doaj   +1 more source

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

Cancer & Metabolism, 2020
Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target.
Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth, Gina M. DeNicola   +8 more
doaj   +1 more source

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation [PDF]

, 2015
Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence
Brignole, Edward J, Davidson, Shawn Michael, Drennan, Catherine L, Fiske, Brian Prescott, Kini, Mitali, Mattaini, Katherine Ruth, Vander Heiden, Matthew G.   +6 more
core   +1 more source

Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis

Cell Reports, 2020
Summary: Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in the serine synthesis pathway in which it is also the rate-limiting enzyme. It is significantly upregulated in many cancers, especially breast cancer.
Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu   +11 more
doaj   +1 more source

PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells

Frontiers in Oncology, 2021
BackgroundPlatinum-based chemotherapy is the first line option for ovarian cancer. The development of resistance to such chemotherapy results in treatment failure, while the underlying mechanisms are poorly understood.MethodsClinical samples were ...
Fangfang Bi, Yuanyuan An, Tianshui Sun, Yue You, Qing Yang   +4 more
doaj   +1 more source

Targeting phosphoglycerate dehydrogenase in multiple myeloma

Experimental Hematology & Oncology, 2021
Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required.
Samah Elsaadi, Ida Steiro, Pegah Abdollahi, Esten N. Vandsemb, Rui Yang, Tobias S. Slørdahl, Torstein Baade Rø, Eline Menu, Anne-Marit Sponaas, Magne Børset   +9 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer

International Journal on Biological Sciences, 2022
Background: Bladder cancer (BCa) is a prevalent urologic malignancy that shows a poor prognosis. Abnormal metabolism and its key genes play a critical role in BCa progression.
Liliang Shen, Junfeng Zhang, Zongtai Zheng, Fu-han Yang, Shenghua Liu, Yuan Wu, Yifan Chen, Tianyuan Xu, Shiyu Mao, Yang Yan, Wei Li, Wentao Zhang, X. Yao   +12 more
semanticscholar   +1 more source

PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Gastric cancer (GC) is one of the leading causes of cancer-related deaths with high degree of intratumoral heterogeneity. Herein, we propose a treatment strategy for chemoresistant GC patients via deciphering metabolic plasticity of Stem ...
Bo Kyung Yoon, Hyeonhui Kim, Tae Gyu Oh, S. Oh, Sugyeong Jo, Minki Kim, Kyungso Chun, Nahee Hwang, Suji Lee, S. Jin, A. Atkins, R. Yu, M. Downes, Jae-Woo Kim, Hyunkyung Kim, Ronald M. Evans, J. Cheong, S. Fang   +17 more
semanticscholar   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source