Results 31 to 40 of about 8,290 (226)

Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

Acta Pharmaceutica Sinica B, 2022
The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have
Chen Chen, Tianyu Zhu, Xiaoqin Liu, Dongrong Zhu, Yi Zhang, Sifang Wu, Chao Han, Hao Zhang, Jianguang Luo, Lingyi Kong   +9 more
doaj   +1 more source

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Poultry Science, 2022
: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear.
Han Wang, Moran Hu, Zhaoxue Ding, Xiaolong Zhou, Songbai Yang, Zhonghao Shen, Feifei Yan, Ayong Zhao   +7 more
doaj   +1 more source

Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma

BMC Medical Genomics, 2023
Background PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer.
He Zhang, Weimin Kong, Xiaoling Zhao, Yunkai Xie, Dan Luo, Shuning Chen   +5 more
doaj   +1 more source

Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer

Advanced Science, 2023
Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model.
Hongwen Zhu, Hua Yu, Hu Zhou, Wencheng Zhu, Xiongjun Wang   +4 more
doaj   +1 more source

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020

Expert Opinion on Therapeutic Patents, 2021
Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010.
Quentin Spillier, Raphaël Frédérick
openaire   +3 more sources

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Molecules, 2022
Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3 ...
Ayesha Sadiqa, Azhar Rasul, Mudassir Hassan, Salma Sultana, Farhat Jabeen   +4 more
doaj   +1 more source

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation [PDF]

, 2015
Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence
Brignole, Edward J, Davidson, Shawn Michael, Drennan, Catherine L, Fiske, Brian Prescott, Kini, Mitali, Mattaini, Katherine Ruth, Vander Heiden, Matthew G.   +6 more
core   +1 more source

Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis

Cell Reports, 2020
Summary: Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in the serine synthesis pathway in which it is also the rate-limiting enzyme. It is significantly upregulated in many cancers, especially breast cancer.
Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu   +11 more
doaj   +1 more source

Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation

Molecular Oncology, 2020
d‐3‐Phosphoglycerate dehydrogenase (PHGDH) conducts an important step in the synthesis of serine. Importantly, the PHGDH gene is often amplified in certain cancers.
Hirofumi Yoshino, Hideki Enokida, Yoichi Osako, Nijiro Nohata, Masaya Yonemori, Satoshi Sugita, Kazuki Kuroshima, Masafumi Tsuruda, Shuichi Tatarano, Masayuki Nakagawa   +9 more
doaj   +1 more source

Targeting phosphoglycerate dehydrogenase in multiple myeloma

Experimental Hematology & Oncology, 2021
Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required.
Samah Elsaadi, Ida Steiro, Pegah Abdollahi, Esten N. Vandsemb, Rui Yang, Tobias S. Slørdahl, Torstein Baade Rø, Eline Menu, Anne-Marit Sponaas, Magne Børset   +9 more
doaj   +1 more source