Results 51 to 60 of about 8,721 (232)

Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways [PDF]

, 2019
The epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer. However, their role in breast cancer recurrence is unclear. In this study, we report that high levels
Badve, Sunil S., Goswami, Chirayu P., Gu, Xiaoping, Gu, Yuan, Gökmen‐Polar, Yesim, Janga, Sarath C., Nallamothu, Gouthami, Neelamraju, Yaseswini, Ryan, Michael, Vieth, Edyta   +9 more
core   +1 more source

Genome-wide analyses identify common variants associated with macular telangiectasia type 2 [PDF]

, 2017
Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS ...
A Bringmann, A Demirkan, A Kottgen, AC Barbosa, AC Len, AJ Mears, Anna Quaglieri, B Gold, B Howie, B Yu, BH Weber, C Giaume, C Toomes, Carolyn Cai, Catherine A Egan, CC Breugem, CC Chang, CW Carr, D Maiti, DA Bessant, EP Rhee, EY Chew, F Brancati, G Pare, G Tikellis, Global Lipids Genetics Consortium, GS Hageman, H Hao, I Eerola, I Eerola, J Bergeron-Sawitzke, J Raffler, J Raffler, J Yang, Jana Zernant, JB van Meurs, JD Cahoy, JDM Gass, JJ Chen, JR Black, JS Danik, K Mittelstrass, K Suhre, KT Oh, KZ Aung, L Bouchard, LA Lange, Lawrence A Yannuzzi, LC Kottyan, Lea Scheppke, LG Fritsche, LG Fritsche, Lisa Baird, LW Klomp, M Borenstein, M Henkemeyer, M Hong, M Sabater-Lleal, M Veiga-da-Cunha, M Zhao, M Zweier, Marcus Fruttiger, Mark Leppert, Martin Friedlander, MB Powner, MC Gillies, ME Kleber, ME Ritchie, Melanie Bahlo, MI Dorrell, MK Ikram, ML Summar, MR Metea, N Le Meur, N Revencu, N Siddiqui, NL Parmalee, NL Parmalee, Nori Matsunami, O Delaneau, P Artimo, Q Lin, Q Lin, R Klein, Rando Allikmets, RF Gariano, RJ Pruim, Roberto Bonelli, RS de Wijn, S Purcell, S Purcell, SH Chung, SH Lee, SR Hannan, SR Williams, SY Shin, T Illig, T Sing, T Watanabe, TD Gelehrter, TE Clemons, TE Clemons, Thomas S Scerri, TW Isaacs, U Menchini, V De Laurenzi, W Bi, W Wooderchak-Donahue, W Xie, WL Hutton, X Sim, Y Onishi, Y Usui, Z Xu   +113 more
core   +1 more source

Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Frontiers in Pharmacology, 2023
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang, Hao Lu, Xinmiao Wang, Qingxia Liu, Jinfeng Hu, Yao Liu, Meihua Jin, Dexin Kong   +7 more
semanticscholar   +1 more source

High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer

Translational Oncology, 2016
Tumors have exceptionally high demands for energy and anabolism because of their rapid growth. The de novo serine synthesis pathway initiated by phosphoglycerate dehydrogenase (PHGDH) has been recognized as a hallmark of metabolic adaption in ...
Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang, Xiaoyu Zhou, Jiahai Shi   +7 more
doaj   +1 more source

Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma

Molecular & Cellular Oncology, 2021
The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
doaj   +1 more source

Cancer Cell Metabolism: One Hallmark, Many Faces [PDF]

, 2012
Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly driven in cancer by a combination ...
Cantor, Jason R., Sabatini, David
core   +2 more sources

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E

Journal of Experimental & Clinical Cancer Research, 2019
Background Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types.
Xuhui Ma, Boya Li, Jie Liu, Yan Fu, Yongzhang Luo   +4 more
doaj   +1 more source

Activation of Serine One-Carbon Metabolism by Calcineurin A beta 1 Reduces Myocardial Hypertrophy and Improves Ventricular Function [PDF]

, 2017
Background In response to pressure overload, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure.
Acin-Perez, R, Antonio Enriquez, J, Bonzon-Kulichenko, E, Cogliati, S, Garcia-Pavia, P, Gomez-Salinero, JM, Lara-Pezzi, E, Lopez-Olaneta, M, Ortiz-Sanchez, P, Padron-Barthe, L, Rosenthal, N, Vazquez, J, Villalba-Orero, M   +12 more
core   +1 more source

Cancer metabolism at a glance [PDF]

, 2016
A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal, Kamphorst, Jurre J., Markert, Elke K., Schug, Zachary T., Tardito, Saverio, Vazquez, Alexei   +5 more
core   +2 more sources

PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer

Cancer Research
PRMT1 promotes chemoresitance in TNBC by methylating metabolic enzymes PFKFB3, PKM2, and PHGDH to augment de novo fatty acid synthesis, indicating that targeting this axis is a potential treatment strategy.
Takehiro Yamamoto, T. Hayashida, Y. Masugi, Kiyotaka Oshikawa, Noriyo Hayakawa, Mai Itoh, Chiyoko Nishime, Masami Suzuki, Aiko Nagayama, Yuko Kawai, T. Hishiki, Tomomi Matsuura, Yoshiko Naito, A. Kubo, Arisa Yamamoto, Yujiro Yoshioka, Tomokazu Kurahori, Misa Nagasaka, Minako Takizawa, Naoharu Takano, Koji Kawakami, Michiie Sakamoto, M. Wakui, Takushi Yamamoto, Yuko Kitagawa, Y. Kabe, Kenichi Horisawa, Atsushi Suzuki, Masaki Matsumoto, M. Suematsu   +29 more
semanticscholar   +1 more source