Results 51 to 60 of about 8,013 (194)
The metabolic reprogramming and vulnerability of SF3B1 mutations
Molecular & Cellular Oncology, 2020 Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear.
W. Brian Dalton
doaj +1 more source
Activation of Serine One-Carbon Metabolism by Calcineurin A beta 1 Reduces Myocardial Hypertrophy and Improves Ventricular Function [PDF]
, 2017 Background In response to pressure overload, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure.
Acin-Perez, R +12 more
core +1 more source
Cancer metabolism at a glance [PDF]
, 2016 A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal +5 more
core +2 more sources
Journal of Experimental & Clinical Cancer Research, 2019 Background Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types.
Xuhui Ma +4 more
doaj +1 more source
Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
doaj +1 more source
Modeling cancer metabolism on a genome scale [PDF]
, 2015 Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton +8 more
core +1 more source
Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
core +2 more sources
Network rewiring is an important mechanism of gene essentiality change. [PDF]
, 2012 Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the ...
Bowie, James U +4 more
core +1 more source
The EMBO Journal, 2022 How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non‐canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer.
openaire +2 more sources
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. [PDF]
, 2016 Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic, undergoing circadian (∼24 h) oscillations in many virus-relevant pathways, but whether daily rhythms ...
Edgar, Rachel S +6 more
core +2 more sources