Results 71 to 80 of about 6,588 (185)

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH) [PDF]

, 2017
\ua9 Unterlass et al. Cancer cells reprogram their metabolism and energy production to sustain increased growth, enable metastasis and overcome resistance to cancer treatments. Although primary roles for many metabolic proteins have been identified, some
Unterlass JE, Basle A, Curtin NJ, Wood RJ, Noble MM, Cano C, Tucker J   +6 more
core   +1 more source

Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)

Pharmaceuticals, 2020
For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments.
Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick   +6 more
doaj   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, Volume 20, Issue 10, Page 2466-2489, October 2026.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

PHGDH is a targetable driver of PDAC progression

Abstract Pancreatic ductal adenocarcinoma (PDAC) arises in a nutrient-deprived microenvironment through progressive stages from pancreatic intraepithelial neoplasia (PanIN) to invasive carcinoma. While serine metabolism supports tumor growth across multiple cancer types, the stage-specific role of de novo serine synthesis in PDAC ...
Yumi Kim, Le Jin Sun, Meredith Long, Samantha Caldwell, H. Carlo Maurer, Kenneth P. Olive, Florian Karreth, Gina M. DeNicola   +7 more
openaire   +1 more source

ApoE lipidation state directs immunometabolic reprogramming of human microglia

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John T. Melchior, Kimberley D. Bruce   +14 more
wiley   +1 more source

Figure S4 from PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma

, 2017
PHGDH
Toshihiko Itesako (521195), Masaya Yonemori (9971910), Nijiro Nohata (521198), Hirofumi Yoshino (440726), Takashi Sakaguchi (8810975), Satoshi Sugita (219157), Hideki Enokida (140946), Satoshi Kofuji (7148117), Rajvir Dahiya (140955), Masayuki Nakagawa (140950), Kazutaka Miyamoto (14926716)   +10 more
core   +1 more source

Proteomic Signatures of Noise‐Induced Hearing Loss in the Mouse Cochlea

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Hearing loss affects over 1.5 billion people worldwide and has substantial social, educational, and economic consequences. Although genetic studies have identified numerous hearing‐loss‐associated genes, the molecular changes accompanying noise‐induced hearing loss (NIHL) remain incompletely understood.
Ana Carla Batissoco, Danillo Alencar‐Coutinho, Ana Carolina Ferreira‐Scatone, Stella Diogo‐Cavassana, Jeanne Oiticica, Karina Lezirovitz, Ricardo Ferreira Bento   +6 more
wiley   +1 more source

PHGDH as a therapeutic node: Natural modulators from TCM, degradation pathways, and emerging TPD strategies

Pharmacological Research
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a promising therapeutic target due to its critical roles in the pathogenesis of cancer and neurological disorders.
Song-Song Shi, Yu-Dan Du, Si-Yi Chen, Wen Zhang, Guo-Wu Rao, Quan Zheng   +5 more
doaj   +1 more source

Precision Nutrition as the Concept of Dietary and Nutritional Interventions for Patients With Malignancies: A Narrative Literature Review and Perspectives

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Dietary and nutritional interventions have gained popularity among patients with cancer undergoing treatment due to the high cost of medical treatment and increased health awareness. Diet, nutrition, psychological stress, and adverse events during treatment have a significant impact on the quality of life of patients with cancer ...
Ken Yamaguchi, Koji Yamanoi, Jumpei Ogura, Ayami Koike, Maki Umemiya, Nozomi Higashiyama, Kazuhiro Kou, Yoshihide Inayama, Rin Mizuno, Taito Miyamoto, Mana Taki, Ryusuka Murakami, Junzo Hamanishi, Mandai Masaki   +13 more
wiley   +1 more source