Results 91 to 100 of about 6,588 (185)
Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy
Being the rate-limiting enzyme within the serine biosynthesis pathway, phosphoglycerate dehydrogenase (PHGDH) is abnormally overexpressed in numerous malignant tumor cells and is a promising target for cancer treatment.
Shuai Tang (325963) +8 more
core +3 more sources
Altered expression of genes involved in the serine synthesis pathway (SSP) in patients with acute myeloid leukemia [PDF]
Journal of Kerman University of Medical SciencesBackground: Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of malignant cells, which rely on various metabolic pathways to sustain their survival and growth.
Parinaz Khadem +4 more
doaj +1 more source
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect
Molecular & Cellular Oncology, 2017 Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj +1 more source
Signal Transduction and Targeted TherapyMetabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng +9 more
doaj +1 more source
CBS, PHGDH and PSAT1 interactive gene network.
, 2016 The differentially expressed genes CBS, PHGDH and PSAT1 interactive network generated automatically using the STRING database (STRING software 9.1) is shown here.
Indira Hewlett (329203) +6 more
core +1 more source
Phosphoglycerate dehydrogenase (PHGDH) [PDF]
Science-Business eXchange, 2011 openaire +3 more sources
Metabolic and non-metabolic roles of PHGDH and their impact on T cell function [PDF]
, 2020 Cell-intrinsic metabolism underpins T cell differentiation and function. Metabolic enzymes can, however, also engage in non-metabolic (moonlighting) roles – which creates potential for functional incompatibilities.
Löliger, Jordan
core
, 2015 In some cases Neu‐Laxova syndrome (NLS) is linked to serine deficiency due to mutations in the phosphoglycerate dehydrogenase (PHGDH) gene. We describe the prenatal and postnatal findings in a fetus with one of the most severe NLS phenotypes described so
Lapunzina, Pablo +11 more
core +1 more source
A PHGDH–Hedgehog Axis Drives 5-FU Chemoresistance in Colorectal Cancer
Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several cancer types.
Mancini, Caterina
core +1 more source
NBA1 Interacts with PHGDH and Promotes Breast Cancer Growth [PDF]
, 2017 NBA1是BRCA1复合体中重要的接头蛋白，对整个BRCA1复合体的构架以及复合体成员蛋白的稳定性十分重要，它参与DNA损伤复合体的组成并且介导DNA的损伤修复。为了探究NBA1新的功能，我们以NBA1为饵进行了蛋白相互作用的筛查，发现PHGDH与NBA1存在着相互作用。PHGDH作为糖酵解通路的旁支——丝氨酸合成通路的第一个分支酶，是下游一系列反应的重要限速因素。此外，在许多乳腺癌的发生发展过程中PHGDH都扮演了重要的角色 ...
吴筠梅
core