Results 91 to 100 of about 5,503 (166)

Phosphoglycerate dehydrogenase (PHGDH) [PDF]

Science-Business eXchange, 2011
openaire   +3 more sources

MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury

Cell Discovery
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant clinical challenge in both diagnosis and treatment.
Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang   +6 more
doaj   +1 more source

FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma

Nature Communications
Cancer cells are often addicted to serine synthesis to support growth. How serine synthesis is regulated in cancer is not well understood. We recently demonstrated protein arginine methyltransferase 1 (PRMT1) is upregulated in hepatocellular carcinoma ...
Li Luo, Xingyun Wu, Jiawu Fan, Lixia Dong, Mao Wang, Yan Zeng, Sijia Li, Wenyong Yang, Jingwen Jiang, Kui Wang   +9 more
doaj   +1 more source

PHGDH Gene [PDF]

, 2020
openaire   +1 more source

PHGDH wt Allele [PDF]

, 2020
openaire   +1 more source

ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis

Cell Death and Disease
Argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, acts as a tumor suppressor in many cancers. To date, the anticancer mechanism of ASS1 has not been fully elucidated. Here, we found that phosphoglycerate dehydrogenase (PHGDH), a key
Wensong Luo, Zizheng Zou, Yuan Nie, Junli Luo, Zhengnan Ming, Xiyuan Hu, Tiao Luo, Min Ouyang, Mingquan Liu, Huicheng Tang, Yuanzhu Xie, Kunjian Peng, Ling Chen, Jiang Zhou, Zhiyong Luo   +14 more
doaj   +1 more source

PHGDH is key for targeting HIF in RCC [PDF]

Nature Reviews Urology, 2017
openaire   +1 more source

1p/19q codeletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas. [PDF]

Neuro Oncol
Udutha S, Batsios G, Taglang C, Gillespie AM, Viswanath P.   +4 more
europepmc   +1 more source

Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease. [PDF]

Protein Sci
Zerbini E, Riva D, Maffioli E, Tedeschi G, Sacchi S, Pollegioni L.   +5 more
europepmc   +1 more source

The "serine code" of metabolic reprogramming: multidimensional roles of the serine synthesis pathway in tumors and novel breakthroughs for targeted therapy. [PDF]

Front Immunol
Su P, Yang Y, Zheng H.
europepmc   +1 more source