Results 91 to 100 of about 8,172 (201)

Predictive Role of Serum Inflammatory Markers in Metastatic Luminal A/B Breast Cancers Receiving CDK‐4/6 Inhibitors Therapy

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Background We conducted this study to evaluate the impact of serum inflammatory markers and histopathological features on prognosis in metastatic hormone receptor positive breast cancer patients treated with first line CDK4/6i (cyclin‐dependent kinase inhibitors).
Nilufer Bulut, Tanju Kapagan, Aykut Ozmen, Gokmen Umut Erdem   +3 more
wiley   +1 more source

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH) [PDF]

Journal of Medicinal Chemistry, 2017
Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors with similar chemical scaffolds.
Séverine Ravez, Cyril Corbet, Quentin Spillier, Alice Dutu, Anita D. Robin, Edouard Mullarky, Lewis C. Cantley, Olivier Feron, Raphaël Frédérick   +8 more
openaire   +2 more sources

Identification and characterization of dysregulated P-element induced wimpy testis-interacting RNAs in head and neck squamous cell carcinoma. [PDF]

, 2019
It is clear that alcohol consumption is a major risk factor in the pathogenesis of head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanism underlying the pathogenesis of alcohol-associated HNSCC remains poorly understood.
Ku, Jonjei, Kuo, Selena Z, Li, Pin Xue, Ongkeko, Weg M, Saad, Maarouf A, Wang-Rodriguez, Jessica, Yu, Michael Andrew, Zheng, Hao   +7 more
core  

Association Signals Unveiled by a Comprehensive Gene Set Enrichment Analysis of Dental Caries Genome-Wide Association Studies [PDF]

, 2013
Gene set-based analysis of genome-wide association study (GWAS) data has recently emerged as a useful approach to examine the joint effects of multiple risk loci in complex human diseases or phenotypes.
Cuenco, Karen T., Feingold, Eleanor, Jia, Peilin, Marazita, Mary L., Wang, Kai, Wang, Lily, Wang, Quan, Zeng, Zhen, Zhao, Zhongming   +8 more
core   +3 more sources

Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)

Pharmaceuticals, 2020
For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments.
Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick   +6 more
doaj   +1 more source

NF-Y activates genes of metabolic pathways altered in cancer cells [PDF]

, 2015
The trimeric transcription factor NF-Y binds to the CCAAT box, an element enriched in promoters of genes overexpressed in tumors. Previous studies on the NF-Y regulome identified the general term metabolism as significantly enriched.
Benatti, Paolo, Chiaramonte, Maria Luisa, Dolfini, Diletta, Gnesutta, Nerina, Hartley, John A., Hochhauser, Daniel, Imbriano, Carol, Lorenzo, Mariangela, Mantovani, Roberto   +8 more
core   +2 more sources

The Crosstalk Mechanisms Between Ferroptosis and Pyroptosis and Their Applications in Diseases: From Molecular Networks to Clinical Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Ferroptosis and pyroptosis are two distinct forms of regulated cell death that play crucial roles in cancer, neurodegeneration, and inflammatory diseases. Ferroptosis is characterised by iron‐dependent lipid peroxidation, while pyroptosis is an inflammatory cell death mediated by gasdermin proteins.
Wei‐Yi Zhao, Lu‐yao Li, Fang‐wang Ye, Jin‐Wei Zhao   +3 more
wiley   +1 more source

Exploiting tumour addiction with a serine and glycine-free diet. [PDF]

, 2017
Understanding cancer metabolism is key to unveil the Achilles’ heel of cancer cells and provide novel therapeutic interventions for patients. While the rerouting of metabolic pathways during development1 or cancer transformation and progression2, 3, 4 ...
B Chaneton, Christian Frezza, EC Cheung, EH Ma, F Kottakis, Gerry Melino, GM DeNicola, I Amelio, I Amelio, Ivano Amelio, J Ye, JW Locasale, K Zaugg, M Agostini, M Sciacovelli, M Sciacovelli, M Yang, OD Maddocks, ODK Maddocks, P Lee, R Possemato, VD Longo   +21 more
core   +2 more sources

The use of ultra-dense array CGH analysis for the discovery of micro-copy number alterations and gene fusions in the cancer genome [PDF]

, 2011
Background Molecular alterations critical to development of cancer include mutations, copy number alterations (amplifications and deletions) as well as genomic rearrangements resulting in gene fusions.
Ewa Przybytkowski, Cristiano Ferrario, Mark Basik   +2 more
core   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source