Results 101 to 110 of about 6,588 (185)

FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma

Nature Communications
Cancer cells are often addicted to serine synthesis to support growth. How serine synthesis is regulated in cancer is not well understood. We recently demonstrated protein arginine methyltransferase 1 (PRMT1) is upregulated in hepatocellular carcinoma ...
Li Luo, Xingyun Wu, Jiawu Fan, Lixia Dong, Mao Wang, Yan Zeng, Sijia Li, Wenyong Yang, Jingwen Jiang, Kui Wang   +9 more
doaj   +1 more source

PHGDH Gene [PDF]

, 2020
openaire   +1 more source

Non-canonical function of PHGDH promotes HCC metastasis by interacting with METTL3

Cellular Oncology
Phosphoglycerate dehydrogenase (PHGDH), a pivotal enzyme in serine synthesis, plays a key role in the malignant progression of tumors through both its metabolic activity and moonlight functions. This study aims to elucidate the non-canonical function of PHGDH in promoting hepatocellular carcinoma (HCC) metastasis through its interaction with ...
Cheng, Bin, Ma, Jing, Tang, Ni, Liu, Rui, Peng, Pai, Wang, Kai   +5 more
openaire   +3 more sources

PHGDH wt Allele [PDF]

, 2020
openaire   +1 more source

ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis

Cell Death and Disease
Argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, acts as a tumor suppressor in many cancers. To date, the anticancer mechanism of ASS1 has not been fully elucidated. Here, we found that phosphoglycerate dehydrogenase (PHGDH), a key
Wensong Luo, Zizheng Zou, Yuan Nie, Junli Luo, Zhengnan Ming, Xiyuan Hu, Tiao Luo, Min Ouyang, Mingquan Liu, Huicheng Tang, Yuanzhu Xie, Kunjian Peng, Ling Chen, Jiang Zhou, Zhiyong Luo   +14 more
doaj   +1 more source

PHGDH is key for targeting HIF in RCC [PDF]

Nature Reviews Urology, 2017
openaire   +1 more source

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway

International Journal of General Medicine
Yuhai Zou,1,* Dongdong Li,1,* Ge Guan,1 Wenting Liu2 1Department of Cardiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, People’s Republic of China; 2Department of Otorhinolaryngology, Guangzhou First People’s ...
Zou Y, Li D, Guan G, Liu W
doaj  

PHGDH in cancer: a narrative review of its functions beyond serine metabolism. [PDF]

Transl Cancer Res
Li J, Zhang H, Zhu G, Xu H.
europepmc   +1 more source

1p/19q codeletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas. [PDF]

Neuro Oncol
Udutha S, Batsios G, Taglang C, Gillespie AM, Viswanath P.   +4 more
europepmc   +1 more source

Mechanistic study of PHGDH enzyme inhibition : towards the development of new anticancer drugs

, 2019
The selective targeting of metabolic differences that allow cancer cells to proliferate appears as a promising strategy to develop novel anticancer agents.
Spillier, Quentin
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