Results 81 to 90 of about 6,588 (185)

PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress

, 2023
Molecular classification of gastric cancer (GC) identified a subgroup of patients showing chemoresistance and poor prognosis, termed SEM (Stem-like/Epithelial-to-mesenchymal transition/Mesenchymal) type in this study.
김재우, 정재호, 황성순, 윤보경   +3 more
core   +1 more source

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Cancer Biology & Medicine
Objective: Tumor-associated macrophages (TAMs) exhibit heterogeneous properties including anti-tumorigenic and pro-tumorigenic phenotypes. The rate-limiting enzyme in de novo serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), has a well ...
Pei Wang, Xin Du, Zhiren Han, Jiaxin Zhong, Jiayu Yuan, Lin Jiang, Beinan Han, Wenkui Fu, Hongde Li, Hai Hu, Zhenkun Na   +10 more
doaj   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC [PDF]

, 2019
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common. By using genome-wide CRISPR/Cas9 library screening, we identify phosphoglycerate dehydrogenase (PHGDH), the first ...
Chin, DW-C, Zhang, A, Tsang, FH-C, WONG, CL-S, Law, C-T, Wei, L, LEE, D, Wong, CC-L, SHEN, J, Ng, IO-L, Zhang, MS, Wong, C-M   +11 more
core   +1 more source

Integrative genomics and regulomics reveal the molecular architecture of complex traits in domestic chickens

iMeta, Volume 5, Issue 5, October 2026.
Domestic chickens (Gallus gallus domesticus) exhibit exceptional phenotypic diversity and provide a valuable model for studying domestication and artificial selection. We integrated whole‐genome resequencing data from ~3000 individuals with 20 slaughter‐related traits.
Wei Han, Chenghao Zhou, Yuxin You, Guohui Li, Yunfen Zhu, Yijun Tang, Tao Zeng, Huiyong Zhang, Qian Xue, Jianmei Yin, Li Chen, Xing Ju, Yixiu Jiang, Jiaqi Cai, Lu Li, Xiaofeng Zhang, Zhaoyu Lin, Jindong Ren, Lizhi Lu, Dijun Chen   +19 more
wiley   +1 more source

Curating the Fetal Genome: Experience of the ClinGen Prenatal Gene Curation Expert Panel (GCEP)

Prenatal Diagnosis, Volume 46, Issue 11, Page 1703-1710, October 2026.
ABSTRACT Objective Expert prenatal focused gene‐disease curation is necessary to accurately inform clinical care in the setting of rapidly expanding prenatal genomic sequencing. Methods An international Prenatal Gene Curation Expert Panel assembled and systematically reviewed genes asserted to be associated with prenatal hydrops, stillbirth, or severe ...
Stephanie N. Galloway, Jessica L. Giordano, Carrie Shawber, Natalie Chandler, Lauren Westerfield, Prenatal GCEP Panel members, Ronald J. Wapner, Wendy Chung, Ignatia B. Van den Veyver, Shagun Aggarwal, Caitlin Baptiste, Brenna Boyd, Amanda Buchanan, Alicia Byrne, Imen Chakchouk, David Chitayat, Lyn Chitty, Pinal Dalwadi, Avinash Dharmadhikari, Lilian Downie, Stephanie Dukhovny, Mythily Ganapathi, Kelly Gilmore, Elena Greenfeld, Lylach Haizler‐Cohen, Vaidehi Jobanputra, Gabrielle Litteken, Hannah Perrin, Julie Ratliff, Rebecca Reimers, Erin Riggs, Teresa Sparks, Samantha Stover, Amanda Thomas‐Wilson, Leandra Tolusso, Neeta Vora, Tsegaselassie Workalemahu, Roni Zemet‐Lazar   +37 more
wiley   +1 more source

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation

Cell Death and Disease
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson’s disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown.
Mengfei Lv, Zhongying Duan, Jinhua Tan, Jiake Liu, Qinqin Wang, Congxiao Wang, Zhaolong Zhang, Xiaona Sun, Rui Liu, Yu Cui   +9 more
doaj   +1 more source

Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation

, 2021
l-Serine (Ser) is synthesized de novo from 3-phosphoglycerate via the phosphorylated pathway committed by phosphoglycerate dehydrogenase (Phgdh). A previous study reported that feeding a protein-free diet increased the enzymatic activity of Phgdh in the ...
Momoko Hamano, Kayoko Esaki, Kazuki Moriyasu, Tokio Yasuda, Sinya Mohri, Shigeki Furuya, Kosuke Tashiro, Yoshio Hirabayashi   +7 more
core   +1 more source

Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation.
Kolari, Kalle, Baumert, Philipp, Kalenius, Elina, Mäntyselkä, Sakari, Hulmi, Juha J., Kuikka, Lauri, Wackerhage, Henning, Kivelä, Riikka, Ylä-Outinen, Laura, Lahtonen, Suvi, Permi, Perttu   +10 more
core   +1 more source

Seriinisynteesireitin PHGDH-entsyymin vaikutus lihassolujen kasvuun ja aineenvaihduntaan

Lihasmassa on tärkeä ihmisen toimintakykyä ja aineenvaihduntaa määrittävä tekijä. Lihasmassan määrään vaikuttaa pääasiassa lihaksissa tapahtuva proteiinisynteesin ja proteiinien hajotuksen suhde.
Lahtonen, Suvi
core   +1 more source