Results 81 to 90 of about 8,172 (201)

The 2014 Beatson International Cancer Conference: Powering the Cancer Machine [PDF]

, 2014
Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic rewiring and the adaptability of the ...
Daniel J Murphy, Jurre J Kamphorst
core   +1 more source

Targeting cancer metabolism: a therapeutic window opens [PDF]

, 2011
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic enzymes for cancer therapy, but ...
A Clementi, A Dimitrakopoulou-Strauss, A Garten, A Le, A Wolf, A Yalcin, AM Groves, AP Halestrap, AP Pereira da Silva, AS Marsin, B Clem, B Dwarakanath, BA Chabner, BK Mohanti, BR Landau, C Algire, C Derst, C Garcia-Echeverria, C Yang, CH Holdsworth, CM Murray, CS Potten, CV Dang, D Hanahan, D Singh, DA Rew, DA Tennant, DA Tennant, DE Bauer, DK Nomura, DR Wise, DW Parsons, E Eschwege, E Furuta, ED Michelakis, EE Calle, EE Calle, ER Mardis, ES Burgos, G Hatzivassiliou, G Marcucci, G Ollenschlager, GA Spoden, GL Semenza, H Linardou, H Shim, H Yan, HA Hirsch, HR Christofk, HR Christofk, I Maestu, I Papandreou, J Kurhanewicz, J Luo, J Yun, JA Engelman, JA Engelman, JA Menendez, JA Meyerhardt, Jason W Locasale, JB Wang, JD Broome, JG Kidd, JK Jiang, JM Brown, JM Evans, JW Kim, JW Locasale, K Brindle, K Chen, K Duvel, K Holen, K Hosono, K Zaugg, KE Wellen, KH Vousden, KM Kennedy, KS Dimmer, L Dang, L Galluzzi, L Tallal, LG Boros, M Buzzai, M Hasmann, M Ko, M Ookhtens, M Pittelli, M Pollak, M Pollak, M Tahiliani, M Takenaka, M Yuneva, MA Weiser, Matthew G. Vander Heiden, MB Boxer, MB Tessem, MC Li, ME Figueroa, MG Vander Heiden, MG Vander Heiden, MG Vander Heiden, MJ Evans, MJ Holness, MJ Ovens, MJ Seltzer, ML Macheda, ML Tainter, MR Stratton, MS Ardawi, MY El-Mir, N El Mjiyad, N Jaffe, N Normanno, NP Curthoys, NP Manes, NY Kalaany, O Kaplan, P Cocco, P Gao, P Sonveaux, P Thirion, PS Ward, R Chowdhury, R Flavin, R Zhou, R Zoncu, RA Cairns, RA Larson, RB Robey, RB Scott, RE Neuman, RG Jones, RG Maki, RG Verhaak, Richard Possemato, RJ Deberardinis, RJ DeBerardinis, RJ Shaw, RJ Shaw, RL Aft, RM Memmott, S Ben-Haim, S Bonnet, S Bruzzone, S Farber, S Farber, S Gross, S Jiralerspong, S Mazurek, S Stacchiotti, S Telang, SH Jee, SJ Bach, SL Bowker, SM Gallagher, SP Mathupala, T Atsumi, T Cheng, T Shlomi, T Yamamoto, TS Yang, V Chajes, VR Fantin, VT DeVita, W Hu, W Kuo, W Xu, WG Kaelin Jr, Y Kumei, Y Ni, Y Yu, YH Ko   +171 more
core   +1 more source

Blood‐Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 5, May 2026.
This study represents the first epigenome‐wide association analysis of Alcohol Use Disorder (AUD) in a genetically and culturally diverse Brazilian cohort. Genome‐wide DNA methylation profiling revealed hypomethylation in genes and pathways related to neuronal development, synaptic organization, intracellular signaling and cellular stress responses in ...
Laís da Silva Pereira‐Rufino, Raissa Mazzer de Sino Romano, Regiane Chiavelli Lamim, Rafael Conte, Denise Ribeiro Gobbo, Marcelo Carvalho da Conceição, Vanessa Kiyomi Ota, Lucas Liro, Leslie Domenici Kulikowsk, Adriana Marcassa Tucci, Ana Lucia de Moraes Horta, Ana Maria Sebastião, Maria Lucia Oliveira Souza‐Formigoni, João Ricardo Nickenig Vissoci, Alexandre Ferro Aissa, Isabel Cristina Céspedes   +15 more
wiley   +1 more source

Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments

Molecules, 2021
The serine biosynthetic pathway is a key element contributing to tumor proliferation. In recent years, targeting of phosphoglycerate dehydrogenase (PHGDH), the first enzyme of this pathway, intensified and revealed to be a promising strategy to develop ...
Quentin Spillier, Séverine Ravez, Simon Dochain, Didier Vertommen, Léopold Thabault, Olivier Feron, Raphaël Frédérick   +6 more
doaj   +1 more source

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK [PDF]

, 2017
葡萄糖是生物中最基本、最主要的营养物质，它不仅是机体能量的主要来源，也是生物质合成的主要原料。因此，葡萄糖的水平对于生物体是极其重要的。然而，在生活中，体内葡萄糖水平的波动是十分常见的，这是因为我们不可能每时每刻都在摄入葡萄糖：睡一大觉、剧烈运动几个小时或者太忙了没时间吃饭，都会引起葡萄糖水平的显著下降。这时，机体能够触发一套有效的过程应对这类“不利情况”，其中最为关键的就是激活“代谢的核心调节”——AMPK。在葡萄糖水平下降时，被激活的AMPK能够迅速启动脂肪、蛋白质的分解代谢，关闭它们的合成代谢 ...
A Sols, AJ Morris, Alexander Gray, AW Kao, B Xiao, B Xiao, C Ritterson Lew, CG Langendorf, Chen-Song Zhang, CS Zhang, D Carling, D. Grahame Hardie, F Rago, FA Ran, FA Ross, G Kroemer, GR Steinberg, H Hu, Hai-Long Piao, Huiyong Yin, IP Salt, Jin-Wei Feng, Jiwen Cui, JS Oakhill, JW Dennis, KH Choi, L Alvarez-Erviti, M Forgac, M Lu, M Lu, M Lu, Mengqi Li, Mingjiang Zhu, MM Mihaylova, MR El-Maghrabi, PM Kelley, SA Hawley, Sheng-Cai Lin, Shu-Yong Lin, Simon A. Hawley, SV Costes, Teng Ma, Terytty Yang Li, TY Li, VP Houde, WA Wilson, Y Zhao, YL Zhang, Yu-Qing Wu, Yue Zong, Zhichao Wang, Zhiyun Ye   +51 more
core   +2 more sources

PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Non‐small cell lung cancer (NSCLC) is a malignant tumor characterized by high morbidity and mortality, as well as metabolic reprogramming. Enhanced serine synthesis plays a crucial role in the aberrant metabolism of NSCLC. Among the three key enzymes involved in serine synthesis, phosphoserine aminotransferase 1 (PSAT1) requires ...
Xijia Zhou, Min Zhao, Yingshu Cao, Xiangyu Zhou, Ke Wang   +4 more
wiley   +1 more source

PHGDH promotes the proliferation and differentiation of primary chicken myoblasts

British Poultry Science, 2022
1. Chicken primary myoblasts (CPMs) are precursors that form muscle fibres. The proliferation and differentiation of CPMs is an essential stage in muscle development. Previous RNA-seq analysis showed that phosphoglycerate dehydrogenase (PHGDH) is a differentially expressed gene in chicken muscle tissue at different growth stages.
L. Chen, Y. L. Wu, H. Ding, K. Z. Xie, T. Zhang, G. X. Zhang, J. Y. Wang   +6 more
openaire   +2 more sources

Translation products of circular RNAs and their functions and application prospects in colorectal cancer

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
•·Proteins encoded by circular RNAs can either promote or suppress the development and progression of colorectal cancer. •·In colorectal cancer, circular RNAs encode proteins via cap‐independent mechanisms, primarily relying on internal ribosome entry sites (IRES) or m6A RNA modifications.
Fengsen Wang, Xuezhou Gu, Xinxiang Li, Maoguang Ma   +3 more
wiley   +1 more source

Down regulating PHGDH affects the lactate production of sertoli cells in varicocele

Reproductive Biology and Endocrinology, 2020
Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele
Wen-bin Guo, Zhen-hui Huang, Cheng Yang, Xian-yuan Lv, Hui Xia, Hu Tian, Jian-kun Yang, Qi-zhao Zhou, Ming-kun Chen, Kang-yi Xue, Cun-dong Liu   +10 more
doaj   +1 more source

Moonlighting functions of phosphoglycerate dehydrogenase in cancer

Cell Reports
Summary: Phosphoglycerate dehydrogenase (PHGDH) is traditionally known for catalyzing the conversion of 3-phosphoglycerate (3-PG) to 3-phosphonooxypyruvate (3-PHP), a key step in the de novo synthesis of serine.
Chuanlong Wang, Sanqi An, Lingyang Zhao, Shuo Li, Jia Huang, Wenkai Ren   +5 more
doaj   +1 more source