Results 81 to 90 of about 5,503 (166)

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway

Journal of Experimental & Clinical Cancer Research
Background Glioma stem-like cells (GSCs) are key drivers of treatment resistance and recurrence in glioblastoma (GBM). Phosphoglycerate dehydrogenase (PHGDH), a crucial enzyme in the de novo serine synthesis pathway (SSP), is implicated in tumorigenesis ...
Xiaojin Liu, Bangxin Liu, Junwen Wang, Hongbin Liu, Jiasheng Wu, Yiwei Qi, Yuan Liu, Hongtao Zhu, Chaoxi Li, Liu Yang, Jian Song, Guojie Yao, Weidong Tian, Kai Zhao, Lin Han, Kai Shu, Suojun Zhang, Jianghong Man, Chao You, Haohao Huang, Ran Li   +20 more
doaj   +1 more source

Mechanical Loading Induces Distinct and Shared Responses in Endothelial and Muscle Cells and Reveals Exercise‐Like Molecular Profiles

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Mechanical loading of human endothelial and muscle cells induced several distinct and shared molecular responses, many of which are commonly observed after exercise in vivo. Both cell types secreted acetate and endothelial cells increased serine synthesis from glucose.
Sakari Mäntyselkä, Erik Niemi, Laura Ylä‐Outinen, Kalle Kolari, Liina Uusitalo‐Kylmälä, Alfredo Ortega‐Alonso, Roosa‐Maria Liimatainen, Vasco Fachada, Perttu Permi, Elina Kalenius, Juha J. Hulmi, Riikka Kivelä   +11 more
wiley   +1 more source

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation

Cell Death and Disease
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson’s disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown.
Mengfei Lv, Zhongying Duan, Jinhua Tan, Jiake Liu, Qinqin Wang, Congxiao Wang, Zhaolong Zhang, Xiaona Sun, Rui Liu, Yu Cui   +9 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma

Cell Death and Disease
Osteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH).
Toshinao Oyama, Caitlyn B. Brashears, Richa Rathore, Heather Benect-Hamilton, Katharine E. Caldwell, Naomi Dirckx, William G. Hawkins, Brian A. Van Tine   +7 more
doaj   +1 more source

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Molecular & Cellular Oncology, 2017
Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj   +1 more source

PHGDH loss promotes hypoxia tolerance through glycolytic reprogramming and enhanced HIF-1 activity

Cell Death Discovery
Radiotherapy is widely used in the treatment of lung cancer; a number of intrinsic and extrinsic mechanisms of resistance exist, including hypoxia. Targeting metabolic pathways that support redox homeostasis has been proposed as a strategy to enhance ...
Eduard Petrosyan, Louise A. W. Martin, Isabelle Legge, John Walsby-Tickle, Adam C. Sedgwick, Mark A. Hill, James S. O. McCullagh, Monica M. Olcina, Ester M. Hammond   +8 more
doaj   +1 more source

PHGDH restricts porcine reproductive and respiratory syndrome virus replication by sustaining cellular antioxidant capacity and redox homeostasis

Microbiology Spectrum
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to the swine industry. Although redox imbalance and oxidative stress are known to favor PRRSV infection, the host determinants that preserve redox homeostasis during PRRSV
Zhangping Yu, Qiongqiong Zhou, Peng Gao, Yongning Zhang, Xinna Ge, Jun Han, Xin Guo, Lei Zhou, Hanchun Yang   +8 more
doaj   +1 more source

Altered expression of genes involved in the serine synthesis pathway (SSP) in patients with acute myeloid leukemia [PDF]

Journal of Kerman University of Medical Sciences
Background: Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of malignant cells, which rely on various metabolic pathways to sustain their survival and growth.
Parinaz Khadem, Ali Keshavarz, Mohammad Hossein Mohammadi, Fateme Mezginejad, Mehdi Allahbakhshian Farsani   +4 more
doaj   +1 more source

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression

Signal Transduction and Targeted Therapy
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng, Pai Peng, Shi Chen, Rui Liu, Xiaosong Li, Ke Wang, Jing Ma, Kai Wang, Ni Tang, Ailong Huang   +9 more
doaj   +1 more source