Results 111 to 120 of about 8,172 (201)

The impact of growth promoters on muscle growth and the potential consequences for meat quality [PDF]

, 2016
To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption.
Aalhus, Adeola, Altarejos, Beermann, Beermann, Bodine, Bohorov, Boisclair, Brameld, Brameld, Brooke, Brown, Bush, Casas, Choe, Ciobanu, Clemmons, Coux, Cruzen, Daughaday, David M. Brown, Denley, Douillard, Duckett, Dunshea, Dunshea, Etherton, Etherton, FAO, Foresight, Fuentes-Prior, Geesink, Glass, Godfray, Goll, Goll, Goncalves, Gunawan, Hemmings, Henckel, Higgins, Hocquette, Hopkins, Houbak, Huang, Huang, John M. Brameld, Karlsson, Kemp, Kemp, Kevin J.P. Ryan, Kim, Kim, Koohmaraie, Koopman, Kretchmar, Krick, Krystal M. Hemmings, Lamare, Lametsch, Larzul, Lefaucheur, Liang, Mareko, Mareko, McNeel, Meersman, Mills, Molebeledi H.D. Mareko, Nonneman, Oksbjerg, Ouali, Page, Parr, Parr, Parr, Patience, Peters, Renand, Robert, Ryan, Ryu, Schiaffino, Sensky, Sentandreu, Seppelt, Siegel, Solomon, Taillandier, Tang, Taylor, Taylor, Tim Parr, Tomas, Underwood, Vann, Velloso, Wang, Wendt, Wheeler, Whipple, White   +101 more
core   +1 more source

Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism [PDF]

, 2012
The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, pathway identification, and pathway kinetics and regulation, among other techniques, has long been used to elucidate and quantify pathways primarily in the
Fendt, Sarah-Maria, Keibler, Mark Andrew, Stephanopoulos, Gregory   +2 more
core   +1 more source

Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]

, 2019
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio, Chichiarelli, Silvia, Eufemi, Margherita, Giamogante, Flavia, Gurtner, Aymone, Macone, Alberto, Magliocca, Fabio Massimo, Manganaro, Roberto, Maras, Bruno, Marrocco, Ilaria, Paglia, Giuliano, Patsilinakos, Alexandros, Perugia, Giacomo, Ragno, Rino, Rubini, Elisabetta   +14 more
core   +1 more source

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation

Cell Death and Disease
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson’s disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown.
Mengfei Lv, Zhongying Duan, Jinhua Tan, Jiake Liu, Qinqin Wang, Congxiao Wang, Zhaolong Zhang, Xiaona Sun, Rui Liu, Yu Cui   +9 more
doaj   +1 more source

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes [PDF]

, 2017
Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association ...
Floegel, Anna, Hoffmann, Per, Jäger, Susanne, Kröger, Janine, Pischon, Tobias, Prehn, Cornelia [u.a.], Sharma, Sapna, Wahl, Simone   +7 more
core   +1 more source

Transcriptome profiling of sheep granulosa cells and oocytes during early follicular development obtained by Laser Capture Microdissection [PDF]

, 2011
Background Successful achievement of early folliculogenesis is crucial for female reproductive function. The process is finely regulated by cell-cell interactions and by the coordinated expression of genes in both the oocyte and in granulosa cells ...
Agnes Bonnet, Beatrice Mandon-Pepin, Claudia Bevilacqua, Corinne Cotinot, Elena Terenina, Francis Benne, Gwenola Tosser-Klopp, Julien Sarry, Laurence Liaubet, Loys Bodin, Magali Sancristobal, Patrice Martin   +11 more
core   +3 more sources

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Molecular & Cellular Oncology, 2017
Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj   +1 more source

Phosphoglycerate dehydrogenase (PHGDH) [PDF]

Science-Business eXchange, 2011
openaire   +3 more sources

MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury

Cell Discovery
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant clinical challenge in both diagnosis and treatment.
Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang   +6 more
doaj   +1 more source

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science
AbstractChemoresistance represents a major challenge for osteosarcoma treatment. Despite the improved knowledge of cancer biology, the core determinants of cisplatin (DDP) resistance in osteosarcoma remain unclear and deserve further exploration. Here, RFWD3 is identified as a key regulator of DDP sensitivity in osteosarcoma using a genome‐wide CRISPR ...
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
openaire   +3 more sources