Results 131 to 140 of about 5,503 (166)

MiR-181a-5p/CDK6 axis attenuates cell proliferation, migration and glycolytic reprogramming in oral squamous cell carcinoma. [PDF]

Cancer Cell Int
Gao J, Yang Y, Chang X, Wang X, Zhang Z, Shi S, Liu Y, Su J, Chen Z, Sun R, Song G.   +10 more
europepmc   +1 more source

Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock. [PDF]

J Biol Chem
Hu P, Ji Z, Xiong H, Yu S, Shan X, Dong H, Jing W, Wang J, Wang Z, Cui Y, Wang B, Zhou Y, Li Z, Tang J, Cui Y, Wang T, Xie K, Yu Q.   +17 more
europepmc   +1 more source

Whole genome screening defines a key role of autophagy in resistance of bovine cells to BVDV infection

Riedel C, Chen H, Rümenapf T, Grebien F, van Son M, Harvey TN, Kent MP, Boyartchuk V.   +7 more
europepmc   +1 more source

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Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors

Cellular and Molecular Life Sciences, 2021
The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated promising tumor-suppressing activities. However, the enzyme properties of PHGDH are not well understood and the discovery of PHGDH inhibitors is still in its infancy.
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao, Qingxiang Sun   +8 more
openaire   +2 more sources

A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism

European Journal of Medicinal Chemistry, 2021
Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in ...
Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian   +7 more
openaire   +2 more sources

Abstract 3014: PHGDH- A therapeutic vulnerability in melanoma

Cancer Research, 2022
Abstract Recurrently amplified oncogenes may represent melanoma vulnerabilities that can be exploited for therapy. The genomic locus containing the Phosphoglycerate Dehydrogenase (PHGDH) gene at chromosome 1p12 is frequently amplified in melanoma.
Neel N. Jasani, Florian Karreth
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The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis

Cell Reports, 2018
NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein, 3-phosphoglycerate dehydrogenase (PHGDH). Importantly, we find that PHGDHhigh breast cancer cell lines are
Steven Gygi, Derek R Clements, Tanveer Sharif   +2 more
exaly   +3 more sources

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020

Expert Opinion on Therapeutic Patents, 2021
Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010.
Quentin Spillier, Raphaël Frédérick
openaire   +2 more sources

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

Cell
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about AD development in the general population.
Sheng Zhong, Wenxin Zhao
exaly   +4 more sources

PHGDH amplification and altered glucose metabolism in human melanoma

Pigment Cell & Melanoma Research, 2011
SummaryThe metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare.
Edouard, Mullarky, Katherine R, Mattaini, Matthew G, Vander Heiden, Lewis C, Cantley, Jason W, Locasale   +4 more
openaire   +2 more sources