Results 151 to 160 of about 6,588 (185)

Dextrorotatory kynurenine suppresses acute rejection through inhibiting M1 macrophage-mediated inflammation. [PDF]

EMBO Mol Med
Zhao Y, Wu J, Li Y, Cao Y, Zhu T, Guo Y, Yang C, Zhu D.   +7 more
europepmc   +1 more source

Amino Acid Metabolic Enzymes in Gastric Cancer: Roles and Mechanisms in Tumorigenesis and Progression. [PDF]

Oncol Res
Wan Z, Quan J, Qiu Y, Zhang Z.
europepmc   +1 more source

RFWD3: A pivotal E3 ubiquitin ligase in DNA damage response, non-neoplastic disorders and multi-system tumorigenesis. [PDF]

Sci Prog
Ding Y, Zhu M, Shu J, Zhou G, Jin R, Chen M, Zhang R, Chang F.   +7 more
europepmc   +1 more source

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis

Cell Reports, 2018
NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein, 3-phosphoglycerate dehydrogenase (PHGDH). Importantly, we find that PHGDHhigh breast cancer cell lines are
Steven P. Gygi, Derek R. Clements, Tanveer Sharif   +2 more
exaly   +4 more sources

Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease

Metabolism: Clinical and Experimental, 2020
Objective: Supplementation with serine attenuates alcoholic fatty liver by regulating homocysteine metabolism and lipogenesis. However, little is known about scrine metabolism in fatty liver disease (FLD).
Byung-Hoon Lee, Dae Won Jun
exaly   +2 more sources

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Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors

Cellular and Molecular Life Sciences, 2021
The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated promising tumor-suppressing activities. However, the enzyme properties of PHGDH are not well understood and the discovery of PHGDH inhibitors is still in its infancy.
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao, Qingxiang Sun   +8 more
openaire   +2 more sources

A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism

European Journal of Medicinal Chemistry, 2021
Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in ...
Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian   +7 more
openaire   +2 more sources

Abstract 3014: PHGDH- A therapeutic vulnerability in melanoma

Cancer Research, 2022
Abstract Recurrently amplified oncogenes may represent melanoma vulnerabilities that can be exploited for therapy. The genomic locus containing the Phosphoglycerate Dehydrogenase (PHGDH) gene at chromosome 1p12 is frequently amplified in melanoma.
Neel N. Jasani, Florian Karreth
openaire   +1 more source

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

Cell
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about AD development in the general population.
Sheng Zhong, Wenxin Zhao, Jessica Li
exaly   +4 more sources

High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy

Molecular Oncology, 2015
We have previously reported the 2D PAGE-based proteomic profiling of a prospective cohort of 78 triple negative breast cancer (TNBC) patients, and the establishment of a cumulative TNBC protein database.
David L Rimm, José Moreira, Irina Gromova   +2 more
exaly   +2 more sources