Results 141 to 150 of about 5,503 (166)
Some of the next articles are maybe not open access.
An idle PHGDH takes control of cell fate
Cell Research, 2023Linchong Sun, Ping Gao
openaire +2 more sources
Increased Expression of PHGDH Under High-Selenium Stress In Vivo
Biological Trace Element ResearchThe purpose of this study is to explore the glycolytic remodeling under high-selenium (Se) stress. Three groups of male C57BL/6J mice were fed on diets with different Se contents (0.03, 0.15, and 0.30 mg Se/kg). Glucose tolerance test (GTT) and insulin tolerance test (ITT) were measured at the third month. Mice were killed at the fourth month.
Qin, Wang +7 more
openaire +2 more sources
Comparative Analysis of the Effects of PSPH and PHGDH Inhibitors on Tumor Cell Proliferation
Investigational New DrugsAbstract Serine metabolism plays a critical role in supporting the rapid proliferation of tumor cells, with PHGDH recognized as a key rate-limiting enzyme and therapeutic target. However, whether its antitumor effects are solely dependent on serine metabolism remains under debate. In this study, we systematically compared the effects of
Yanbing, Wang, Longze, Sha
openaire +2 more sources
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes
Translational ResearchDiabetic kidney disease (DKD) is a main cause of end-stage renal disorder, yet its pathogenesis is still incompletely understood. Ferroptosis has been implicated in DKD progression; however, its regulatory mechanisms remain unclear. Phosphoglycerate dehydrogenase (PHGDH), a key enzyme in serine biosynthesis, has been minimally studied in DKD ...
Yinghui Wang +7 more
openaire +2 more sources
The role of PHGDH in hypoxic adaptation and metabolic reprogramming
Hypoxia is a common feature of solid tumours and is associated with poor prognosis and resistance to therapy. Attempts to therapeutically target hypoxic tumour cells have shown limited clinical success. This thesis investigates the role of phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine synthesis pathway (SSP), in hypoxicopenaire +1 more source
PHGDH promotes esophageal squamous cell carcinoma progression via Wnt/β-catenin pathway
Cellular Signalling, 2023Ziming Dong +2 more
exaly
Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
Cell Metabolism, 2018Charlotte Dubois +2 more
exaly