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The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of L-serine from glucose. Astrocytic L-serine was proposed to regulate NMDAR activity by shuttling to neurons to sustain D-serine production, but this ...
Herman Wolosker, Simone Engelender, Marialaura Marchetti   +2 more
exaly   +2 more sources

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PHGDH amplification and altered glucose metabolism in human melanoma

Pigment Cell & Melanoma Research, 2011
SummaryThe metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare.
Edouard, Mullarky, Katherine R, Mattaini, Matthew G, Vander Heiden, Lewis C, Cantley, Jason W, Locasale   +4 more
openaire   +2 more sources

An idle PHGDH takes control of cell fate

Cell Research, 2023
Linchong Sun, Ping Gao
openaire   +2 more sources

Increased Expression of PHGDH Under High-Selenium Stress In Vivo

Biological Trace Element Research
The purpose of this study is to explore the glycolytic remodeling under high-selenium (Se) stress. Three groups of male C57BL/6J mice were fed on diets with different Se contents (0.03, 0.15, and 0.30 mg Se/kg). Glucose tolerance test (GTT) and insulin tolerance test (ITT) were measured at the third month. Mice were killed at the fourth month.
Qin, Wang, Jianrong, Wang, Xue, Zhang, Yiqun, Liu, Feng, Han, Xuesong, Xiang, Yanbin, Guo, Zhen-Wu, Huang   +7 more
openaire   +2 more sources

Phosphoglycerate dehydrogenase (PHGDH) deficiency without epilepsy mimicking primary microcephaly

American Journal of Medical Genetics Part A, 2017
Phosphoglycerate dehydrogenase (PHGDH) deficiency (OMIM 256520) is a rare autosomal recessive disorder of serine synthesis, with mostly severe congenital microcephaly, caused by mutations in the PHGDH gene. Fourteen patients reported to date show severe, early onset, drug resistant epilepsy.
Antoine Poli, Yoann Vial, Damien Haye, Sandrine Passemard, Manuel Schiff, Hala Nasser, Catherine Delanoe, Emma Cuadro, Rémi Kom, Narcisse Elanga, Anne Favre, Séverine Drunat, Alain Verloes   +12 more
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PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes

Translational Research
Diabetic kidney disease (DKD) is a main cause of end-stage renal disorder, yet its pathogenesis is still incompletely understood. Ferroptosis has been implicated in DKD progression; however, its regulatory mechanisms remain unclear. Phosphoglycerate dehydrogenase (PHGDH), a key enzyme in serine biosynthesis, has been minimally studied in DKD ...
Yinghui Wang, Qingqing Zhang, Shasha Lv, Xueling Wang, Qingzhen Liu, Xiangchun Liu, Yaping Zhang, Gang Liu   +7 more
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PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

Cell Metabolism, 2023
Yi Fan, Daniel Yoshor
exaly  

PHGDH promotes esophageal squamous cell carcinoma progression via Wnt/β-catenin pathway

Cellular Signalling, 2023
Ziming Dong, Yihuan Chen, Xiaoshuo Dai
exaly  

Discovery of PHGDH inhibitors by virtual screening and preliminary structure–activity relationship study

Bioorganic Chemistry, 2022
Dingding Gao, Min Huang, Ping Tian
exaly  

Targeting the PHGDH-mTOR Metabolic Axis in Osteosarcoma

2021
openaire   +1 more source