Results 181 to 190 of about 8,172 (201)

PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy

Cancer Discovery, 2023
Abstract Phosphoglycerate dehydrogenase (PHGDH) inhibition improves T-cell therapy efficacy in glioblastoma.
openaire   +1 more source

A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism

European Journal of Medicinal Chemistry, 2021
Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in ...
Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian   +7 more
openaire   +2 more sources

Increased Expression of PHGDH Under High-Selenium Stress In Vivo

Biological Trace Element Research
The purpose of this study is to explore the glycolytic remodeling under high-selenium (Se) stress. Three groups of male C57BL/6J mice were fed on diets with different Se contents (0.03, 0.15, and 0.30 mg Se/kg). Glucose tolerance test (GTT) and insulin tolerance test (ITT) were measured at the third month. Mice were killed at the fourth month.
Qin, Wang, Jianrong, Wang, Xue, Zhang, Yiqun, Liu, Feng, Han, Xuesong, Xiang, Yanbin, Guo, Zhen-Wu, Huang   +7 more
openaire   +2 more sources

An idle PHGDH takes control of cell fate

Cell Research, 2023
Linchong Sun, Ping Gao
openaire   +2 more sources

PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism

Cell Death & Differentiation
Immune cells modify their metabolic pathways in response to fungal infections. Nevertheless, the biochemical underpinnings need to be better understood. This study reports that fungal infection drives a switch from glycolysis to the serine synthesis pathway (SSP) and one-carbon metabolism by inducing the interaction of spleen tyrosine kinase (SYK) and ...
Xinyong Zhang, Dongdong Hu, Xiaoyan Sun, Yichun Gu, Yong Zhou, Chuanxin Su, Shi Liu, Caiyan Zhang, Guoping Lu, Qiwen Wu, Aidong Chen   +10 more
openaire   +2 more sources

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

Cell Metabolism, 2023
Duo Zhang, Menggui Huang, Kathryn E Wellen   +2 more
exaly  

Insights from Natural Product PHGDH Inhibitor Studies

Journal of Cellular Signaling, 2022
openaire   +1 more source

The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress

Nature Metabolism, 2021
Tao Chen, Yuzheng Zhao, Yuhui Jiang
exaly  

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Cancer Discovery, 2020
Bryan Ngo, Victoria Osorio-Vasquez, Sophia Doll   +2 more
exaly  

Targeting PHGDH exerts anti-oncogenic effects in bladder cancer

European Urology Supplements, 2019
H. Yoshino, Y. Osako, M. Yonemori, S. Tatarano, H. Enokida, M. Nakagawa   +5 more
openaire   +1 more source