Results 171 to 180 of about 8,172 (201)

Amino acids metabolism: a potential target for cancer treatment. [PDF]

Mol Cancer
Ren S, Zhou X, Wang Z, Yuan K.
europepmc   +1 more source

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Nature, 2022
Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity has also been observed4, yet its role in cancer progression is less explored.
Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni   +2 more
exaly   +7 more sources

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Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors

Cellular and Molecular Life Sciences, 2021
The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated promising tumor-suppressing activities. However, the enzyme properties of PHGDH are not well understood and the discovery of PHGDH inhibitors is still in its infancy.
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao, Qingxiang Sun   +8 more
openaire   +2 more sources

PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms

Cell Metabolism, 2022
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
Xu Chen, Riccardo Calandrelli, Zhangming Yan   +2 more
exaly   +5 more sources

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis

Cell Reports, 2018
NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein, 3-phosphoglycerate dehydrogenase (PHGDH). Importantly, we find that PHGDHhigh breast cancer cell lines are
Michael A Giacomantonio, Joao A Paulo, Derek R Clements   +2 more
exaly   +3 more sources

Abstract 3014: PHGDH- A therapeutic vulnerability in melanoma

Cancer Research, 2022
Abstract Recurrently amplified oncogenes may represent melanoma vulnerabilities that can be exploited for therapy. The genomic locus containing the Phosphoglycerate Dehydrogenase (PHGDH) gene at chromosome 1p12 is frequently amplified in melanoma.
Neel N. Jasani, Florian Karreth
openaire   +1 more source

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

Cell
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about AD development in the general population.
Sheng Zhong
exaly   +4 more sources

Phosphoglycerate dehydrogenase (PHGDH) deficiency without epilepsy mimicking primary microcephaly

American Journal of Medical Genetics Part A, 2017
Phosphoglycerate dehydrogenase (PHGDH) deficiency (OMIM 256520) is a rare autosomal recessive disorder of serine synthesis, with mostly severe congenital microcephaly, caused by mutations in the PHGDH gene. Fourteen patients reported to date show severe, early onset, drug resistant epilepsy.
Antoine Poli, Yoann Vial, Damien Haye, Sandrine Passemard, Manuel Schiff, Hala Nasser, Catherine Delanoe, Emma Cuadro, Rémi Kom, Narcisse Elanga, Anne Favre, Séverine Drunat, Alain Verloes   +12 more
openaire   +2 more sources

Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease

Cell Metabolism, 2022
Recent work from Bonvento and colleagues indicated that synaptic and memory deficits in early Alzheimer's disease (AD) are related to a shortage in L-serine production in astrocytes. Here, the authors, responding to correspondence from Chen and colleagues, discuss how this deficiency does not necessarily require a decrease in PHGDH expression and ...
Bonvento, Gilles, Oliet, Stéphane H.R., Panatier, Aude   +2 more
openaire   +2 more sources

PHGDH amplification and altered glucose metabolism in human melanoma

Pigment Cell & Melanoma Research, 2011
SummaryThe metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare.
Edouard, Mullarky, Katherine R, Mattaini, Matthew G, Vander Heiden, Lewis C, Cantley, Jason W, Locasale   +4 more
openaire   +2 more sources