Results 61 to 70 of about 8,721 (232)
Advanced Science, 2023 Numerous studies have demonstrated that individual proteins can moonlight. Eukaryotic Initiation translation factor 3, f subunit (eIF3f) is involved in critical biological functions; however, its role independent of protein translation in regulating ...
Qihao Pan +18 more
doaj +1 more source
Network rewiring is an important mechanism of gene essentiality change. [PDF]
, 2012 Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the ...
Bowie, James U +4 more
core +1 more source
Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells. [PDF]
iScienceSummary: Human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) differentiation can improve using chemical compounds which mimic early heart development.
Umei TC +16 more
europepmc +2 more sources
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. [PDF]
, 2016 Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic, undergoing circadian (∼24 h) oscillations in many virus-relevant pathways, but whether daily rhythms ...
Edgar, Rachel S +6 more
core +2 more sources
Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
core +2 more sources
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Cell ReportsSummary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available.
Penghui Hu +16 more
doaj +1 more source
The metabolic reprogramming and vulnerability of SF3B1 mutations
Molecular & Cellular Oncology, 2020 Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear.
W. Brian Dalton
doaj +1 more source
Modeling cancer metabolism on a genome scale [PDF]
, 2015 Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton +8 more
core +1 more source
Serine one-carbon catabolism with formate overflow [PDF]
, 2016 Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in
Athineos, Dimitris +11 more
core +1 more source
Ecotoxicology and Environmental SafetyCadmium (Cd) is a widespread environmental contaminant, which has been classified as a human carcinogen. Phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme involved in the serine biosynthesis pathway, was reported to be able to ...
Chunpeng Gao +5 more
doaj +1 more source