Results 81 to 90 of about 8,721 (232)

Suboptimal culture conditions induce more deviations in gene expression in male than female bovine blastocysts [PDF]

, 2016
BACKGROUND: Since the development of in vitro embryo production in cattle, different supplements have been added to culture media to support embryo development, with serum being the most popular.
Bogado Pascottini, Osvaldo Américo, De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Goossens, Karen, Gutierrez-Adan, Alfonso, Heras Garcia, Sonia, Leroy, Jo, Peelman, Luc, Van Nieuwerburgh, Filip, Van Poucke, Mario, Van Soom, Ann   +11 more
core   +11 more sources

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Cell Reports, 2020
Summary: Mechanistic or mammalian target of rapamycin complex 1 (mTORC1) is an important regulator of effector functions, proliferation, and cellular metabolism in macrophages.
Jayne Louise Wilson, Thomas Nägele, Monika Linke, Florian Demel, Stephanie D. Fritsch, Hannah Katharina Mayr, Zhengnan Cai, Karl Katholnig, Xiaoliang Sun, Lena Fragner, Anne Miller, Arvand Haschemi, Alexandra Popa, Andreas Bergthaler, Markus Hengstschläger, Thomas Weichhart, Wolfram Weckwerth   +16 more
doaj   +1 more source

Correction: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis [PDF]

, 2022
Debangshu Samanta, Youngrok Park, Shaida A. Andrabi, Laura M. Shelton, Daniele M. Gilkes, Gregg L. Semenza, Debangshu Samanta, Youngrok Park, Shaida A. Andrabi, Laura M. Shelton, Daniele M. Gilkes, Gregg L. Semenza   +11 more
openalex   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, EarlyView.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source

NF-Y activates genes of metabolic pathways altered in cancer cells [PDF]

, 2015
The trimeric transcription factor NF-Y binds to the CCAAT box, an element enriched in promoters of genes overexpressed in tumors. Previous studies on the NF-Y regulome identified the general term metabolism as significantly enriched.
Benatti, Paolo, Chiaramonte, Maria Luisa, Dolfini, Diletta, Gnesutta, Nerina, Hartley, John A., Hochhauser, Daniel, Imbriano, Carol, Lorenzo, Mariangela, Mantovani, Roberto   +8 more
core   +2 more sources

Benefits of Nutrients and Phytonutrients in Nuts and Legumes on Platelet Aggregation Through DNA Methylation

Molecular Nutrition &Food Research, EarlyView.
Nuts and legumes contain both nutrients and bioactive compounds supporting cardiovascular health related to influencing DNA methylation. These foods are related to reducing oxidative stress, supplying methyl donors, and modulating genes involved in platelet function, such as PEAR1 and mitochondrial genes, in association with helping reduce inflammation
Siwaphorn Chaimati, Jintana Sirivarasai, Nareerat Sutjarit   +2 more
wiley   +1 more source

Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer

Translational Oncology, 2016
Phosphoglycerate dehydrogenase (PHGDH) plays an essential role in cancer-specific metabolic reprogramming. It has been reported as a putative metabolic oncogene in several types of human malignant tumors, such as breast cancer and melanoma.
Xiao-qin Jia, Shu Zhang, Hui-jun Zhu, Wei Wang, Jin-hong Zhu, Xu-dong Wang, Jian-feng Qiang   +6 more
doaj   +1 more source

Metabolic requirements for cancer cell proliferation [PDF]

, 2018
Background: The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated rates of growth and division.
Iliopoulos, Othon, Keibler, Mark Andrew, Kelleher, Joanne Keene, Stephanopoulos, Gregory, Vander Heiden, Matthew G., Wasylenko, Thomas Michael   +5 more
core   +1 more source

cirSIRT5 induces ferroptosis in bladder cancer by forming a ternary complex with SYVN1/PHGDH

Cell Death Discovery
Bladder cancer (BC) represents a prevalent and formidable malignancy necessitating innovative diagnostic and therapeutic strategies. Circular RNAs (circRNAs) have emerged as crucial regulators in cancer biology.
Weijian Li, Y. Ou, Fangdie Ye, Zhang Cheng, Ziang Chen, Quan Zhou, Xiang Yan, Haowen Jiang   +7 more
semanticscholar   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source