Results 81 to 90 of about 8,013 (194)

Metabolic requirements for cancer cell proliferation [PDF]

, 2018
Background: The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated rates of growth and division.
Iliopoulos, Othon, Keibler, Mark Andrew, Kelleher, Joanne Keene, Stephanopoulos, Gregory, Vander Heiden, Matthew G., Wasylenko, Thomas Michael   +5 more
core   +1 more source

The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders [PDF]

, 2016
INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases ...
Cortès-Saladelafont, Elisenda, Fernández-Ramos, Joaquín A, Friedman, Jennifer, Garcia-Cazorla, Àngels, Honzik, Tomas, Horvath, Gabriella, International Working Group on Neurotransmitter related disorders (iNTD), Jeltsch, Kathrin, Jung-Klawitter, Sabine, Kurian, Manju A, Kuseyri, Oya, Lopez-Laso, Eduardo, Mastrangelo, Mario, Opladen, Thomas, Pearson, Toni, Pons, Roser, Scholl-Bürgi, Sabine, Wassenberg, Tessa   +17 more
core   +4 more sources

Down regulating PHGDH affects the lactate production of sertoli cells in varicocele

Reproductive Biology and Endocrinology, 2020
Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele
Wen-bin Guo, Zhen-hui Huang, Cheng Yang, Xian-yuan Lv, Hui Xia, Hu Tian, Jian-kun Yang, Qi-zhao Zhou, Ming-kun Chen, Kang-yi Xue, Cun-dong Liu   +10 more
doaj   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Analyses of plasma multi‐omic data across ancestries identify novel pathways implicated in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Few genetic studies on Alzheimer's disease (AD) have incorporated multiple ancestries and omic datasets to pinpoint actionable AD risk effectors for each ancestry. METHODS Here, we first performed genetic colocalization between molecular phenotypes (proteomics and metabolomics) from two ancestral groups (European [EUR] and African
Chengran Yang, Jigyasha Timsina, Menghan Liu, John Budde, Pat Kohlfeld, William Brock, John C. Morris, David M. Holtzman, Yun Ju Sung, Carlos Cruchaga   +9 more
wiley   +1 more source

Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism [PDF]

, 2012
The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, pathway identification, and pathway kinetics and regulation, among other techniques, has long been used to elucidate and quantify pathways primarily in the
Fendt, Sarah-Maria, Keibler, Mark Andrew, Stephanopoulos, Gregory   +2 more
core   +1 more source

PHGDH promotes the proliferation and differentiation of primary chicken myoblasts

British Poultry Science, 2022
1. Chicken primary myoblasts (CPMs) are precursors that form muscle fibres. The proliferation and differentiation of CPMs is an essential stage in muscle development. Previous RNA-seq analysis showed that phosphoglycerate dehydrogenase (PHGDH) is a differentially expressed gene in chicken muscle tissue at different growth stages.
L. Chen, Y. L. Wu, H. Ding, K. Z. Xie, T. Zhang, G. X. Zhang, J. Y. Wang   +6 more
openaire   +2 more sources

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Cell Reports, 2020
Summary: Mechanistic or mammalian target of rapamycin complex 1 (mTORC1) is an important regulator of effector functions, proliferation, and cellular metabolism in macrophages.
Jayne Louise Wilson, Thomas Nägele, Monika Linke, Florian Demel, Stephanie D. Fritsch, Hannah Katharina Mayr, Zhengnan Cai, Karl Katholnig, Xiaoliang Sun, Lena Fragner, Anne Miller, Arvand Haschemi, Alexandra Popa, Andreas Bergthaler, Markus Hengstschläger, Thomas Weichhart, Wolfram Weckwerth   +16 more
doaj   +1 more source

Association Signals Unveiled by a Comprehensive Gene Set Enrichment Analysis of Dental Caries Genome-Wide Association Studies [PDF]

, 2013
Gene set-based analysis of genome-wide association study (GWAS) data has recently emerged as a useful approach to examine the joint effects of multiple risk loci in complex human diseases or phenotypes.
Cuenco, Karen T., Feingold, Eleanor, Jia, Peilin, Marazita, Mary L., Wang, Kai, Wang, Lily, Wang, Quan, Zeng, Zhen, Zhao, Zhongming   +8 more
core   +3 more sources