Results 41 to 50 of about 714,665 (318)

In or Out of Equilibrium? How Microbial Activity Controls the Oxygen Isotopic Composition of Phosphate in Forest Organic Horizons With Low and High Phosphorus Availability

Frontiers in Environmental Science, 2020
While there are estimates of the abiotic processes contribution to soil phosphorus (P) availability, less is known about the contribution of biological processes.
Chiara Pistocchi, Chiara Pistocchi, Éva Mészáros, Éva Mészáros, Emmanuel Frossard, E. K. Bünemann, E. K. Bünemann, Federica Tamburini   +7 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

A general biochemical kinetics data fitting algorithm for quasi-steady-state detection

Lietuvos Matematikos Rinkinys, 2016
We develop a general algorithm for fitting the biochemical kinetics data. The developed algorithm searches and analyzes numerous minima. This approach allows us to analyze biochemical data without a priori quasi-steady-state assumptions.
Justinas V. Daugmaudis, Audrius Laurynėnas, Juozas Kulys, Feliksas Ivanauskas   +3 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Cerium Oxide Nanoparticles Role as Antioxidant

Medical Journal of Babylon
Cerium oxide nanoparticles (NPs), also known as ceria NPs, are particles of cerium oxide with sizes in the nanometer range. Cerium oxide (CeO2) is a compound composed of cerium and oxygen, and when it is reduced to NPs, it exhibits unique properties and ...
Sura A. Abdulsattar
doaj   +1 more source

Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction

Frontiers in Molecular Neuroscience, 2019
Associative long-term memories (LTMs) support long-lasting behavioral changes resulting from sensory experiences. Retrieval of a stable LTM by means of a large number of conditioned stimulus (CS) alone presentations produces inhibition of the original ...
Mario Rafael Pagani, Emiliano Merlo, Emiliano Merlo   +2 more
doaj   +1 more source

Cdc25 Phosphatases and Cancer [PDF]

Chemistry & Biology, 2004
The Cdc25 phosphatases function as key regulators of the cell cycle during normal eukaryotic cell division and as mediators of the checkpoint response in cells with DNA damage. The role of Cdc25s in cancer has become increasingly evident in recent years.
Johannes Rudolph, Kolbrun Kristjansdottir   +1 more
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source