Results 121 to 130 of about 3,784,388 (393)

FGF23 and Phosphate–Cardiovascular Toxins in CKD

Toxins, 2019
Elevated levels of fibroblast growth factor 23 (FGF23) and phosphate are highly associated with increased cardiovascular disease and mortality in patients suffering from chronic kidney disease (CKD).
Isabel Vogt, Maren Leifheit-Nestler
doaj   +1 more source

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

Science Translational Medicine, 2018
Tenapanor inhibits sodium/hydrogen exchanger isoform 3 to reduce intestinal phosphate absorption via reduction of passive paracellular phosphate flux. Phosphate in flux Kidney failure can decrease the excretion of phosphate, leading to elevated phosphate
A. King, Matthew Siegel, Ying He, Baoming Nie, Ji Wang, S. Koo-McCoy, N. Minassian, Qumber Jafri, D. Pan, Jill Kohler, Padmapriya Kumaraswamy, K. Kozuka, J. G. Lewis, D. Dragoli, D. Rosenbaum, D. O'Neill, Allein Plain, P. Greasley, A. Jönsson-Rylander, D. Karlsson, Margareta Behrendt, M. Strömstedt, T. Rydén-Bergsten, T. Knöpfel, E. M. Pastor Arroyo, N. Hernando, J. Marks, M. Donowitz, C. Wagner, R. T. Alexander, J. Caldwell   +30 more
semanticscholar   +1 more source

High-Affinity Phosphate-Binding Protein (PBP) For Phosphorous Recovery: Proof of Concept Using Recombinant \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 2016
Phosphorus (P) is a critical, non-renewable nutrient; yet excess discharges can lead to eutrophication and deterioration of water quality. Thus, P removal from water must be coupled with P recovery to achieve sustainable P management. P-specific proteins
Ballent, Wendy, Mayer, Brooke, Yang, Yu
core   +1 more source

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium-Phosphate Homeostasis in Healthy Older Cats [PDF]

, 2016
Background Dietary phosphate and protein restriction decreases plasma PTH and FGF‐23 concentrations and improves survival time in azotemic cats, but has not been examined in cats that are not azotemic.
Antoniucci, Backlund, Barber, Barber, Berndt, Brown, Burnett, Dong, Elliott, Ferrari, Finch, Finch, Finch, Freeman, Geddes, Geddes, Greene, Hall, Hoek, Hutchins-Wiese, Isakova, Isakova, Isakova, Jepson, Jepson, Jepson, Jepson, Kamycheva, Kumar, Laflamme, Larsson, Lulich, Marino, Moe, Muntner, Nishida, NRC, Paepe, Parker, Pineda, Reynolds, Ross, Saito, Schulz, Shipov, Sigrist, Spatz, Trivedi, Wakeling, Wakeling, Williams, Zhang   +51 more
core   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Modifying Phosphate Toxicity in Chronic Kidney Disease

Toxins, 2019
Phosphate toxicity is a well-established phenomenon, especially in chronic kidney disease (CKD), where hyperphosphatemia is a frequent occurrence when CKD is advanced. Many therapeutic efforts are targeted at phosphate, and comprise dietary intervention,
Marc Vervloet
doaj   +1 more source

How do arbuscular mycorrhizal fungi handle phosphate? New insight into fine-tuning of phosphate metabolism.

New Phytologist, 2018
Contents Summary 1116 I. Introduction 1116 II. Foraging for phosphate 1117 III. Fine-tuning of phosphate homeostasis 1117 IV. The frontiers: phosphate translocation and export 1119 V.
T. Ezawa, Katsuharu Saito
semanticscholar   +1 more source

PROM Khad an efficient source of P to replace the costly chemical Phosphatic Fertilizer [PDF]

, 2012
The subsidy on phosphate fertilizers rose to an unacceptable level while alternate cost effective technologies are available. Fertilizer industry needs to develop innovative products using the recent advances in the agricultural sciences.
DMR Sekhar, MK Katewa, MS Shaktawat
core   +1 more source

Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family. [PDF]

, 2015
BackgroundIt is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage.
Cooper, Arthur JL, Downs, Diana M, ElBadawi-Sidhu, Mona, Fiehn, Oliver, Gerdes, Svetlana, Hanson, Andrew D, Hodge-Hanson, Kelsey, Niehaus, Thomas D, Zhukov, Aleksey   +8 more
core   +2 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source