Results 71 to 80 of about 917,897 (332)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Fast preparative isoelectric focusing of phycocyanin subunits in layers of granulated gels [PDF]

, 1987
A new method is presented for the fast preparative separation of the light-harvesting photosynthetic pigment C-phycocanin into its and subunits, which is based on isoelectric focusing in layers of granutaled gels containing 7 M urea. The method has been
Fischer, Richard, John, Wolfhart, Köst, Hans-Peter, Köst-Reyes, Eliana, Scheer, Hugo, Schneider, Siegfried   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Selective laser sintering of hydroxyapatite reinforced polyethylene composites for bioactive implants and tissue scaffold development [PDF]

, 2006
Selective laser sintering (SLS) has been investigated for the production of bioactive implants and tissue scaffolds using composites of high-density polyethylene (HDPE) reinforced with hydroxyapatite (HA) with the aim of achieving the rapid manufacturing
Berry E., Bonfield W., Boyan B. D., Chua C. K., Das S., Di Silvio L., Eniwumide J. O., Hing K. A., Kasemo B., Mercuri L. G., Mikos A. G., Rimell J. T., Tan K. H., Tanner K. E., Vacanti J. P., Vail N. K., Wang M., Williams J. D., Williams J. M., Zhang Y.   +19 more
core   +2 more sources

Phosphate binders in uraemia: pharmacodynamics, pharmacoeconomics, pharmacoethics [PDF]

Nephrology Dialysis Transplantation, 2002
In the past nephrologists were aware that the hyperphosphataemia of advanced renal failure triggered hyperparathyroidism, but because only few patients die from skeletal problems, hyperphosphataemia was treated with benign neglect. The panorama has abruptly changed after evidence accrued suggesting that hyperphosphataemia has adverse cardiovascular ...
Olaf, Hergesell, Eberhard, Ritz
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mechanical Properties and Biological Responses of Bioactive Glass Ceramics Processed using Indirect SLS [PDF]

, 2005
This paper will report on research which aims to generate bone replacement components by processing bioactive glass-ceramic powders using indirect selective laser sintering.
Dalgarno, K. W., Dyson, J., Genever, P., Goodridge, R. D., Ohtsuki, C., Wood, D. J., Xiao, K.   +6 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Lanthanum carbonate for dialysis patients with hyperphosphataemia resistant to sevelamer: A retrospective cohort study

Cogent Medicine, 2016
Introduction: Lanthanum carbonate (LC) and sevelamer hydrochloride (SH) are non-calcium-based phosphate binders (NCPB), used to manage hyperphosphatemia in patients with chronic kidney disease.
Asrar Khan, Titi Chen, Anis Khan, Elaine Chan, Karen Byth, Jackson Tan, David Harris   +6 more
doaj   +1 more source