Results 141 to 150 of about 2,579,257 (273)

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Arabidopsis Extra-Large G Proteins (XLGs) in phosphate homeostasis [PDF]

, 2018
Phosphorus, which is taken up as inorganic phosphate (Pi), is one of the most limiting nutrients for plants. To maintain Pi homeostasis, many proteins (e.g.
Sabater Royo, Irene, Ried, Martina, Hothorn, Michael   +2 more
core  

TRANSLATIONAL CHARACTERIZATION OF ACUTE PHOSPHATE DISPOSITION AS IT RELATES TO BONE AND MINERAL HOMEOSTASIS AND CHRONIC KIDNEY DISEASE

, 2021
Elevated serum phosphate is an independent risk factor for cardiovascular disease (CVD) in the general population, and this elevated risk is most prominent in the setting of chronic kidney disease (CKD). Dysregulation of mineral homeostasis is a hallmark
Turner, Mandy
core  

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Molecular regulators of phosphate homeostasis in plants

, 2014
An appropriate cellular phosphate (Pi) concentration is indispensable for essential physiological and biochemical processes. To maintain cellular Pi homeostasis, plants have developed a series of adaptive responses to facilitate external Pi acquisition ...
Chiou, T.J., Lin, S.I., Lin, W.Y.
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

HvPHR1 as a key gene in maintaining phosphate homeostasis in barley

Plant Stress
Phosphorus is an essential macronutrient for all living organisms. Although it is abundant in the Earth’s crust, inorganic phosphate (Pi)—accessible to plants—is often limited due to the soil’s physicochemical properties. To cope with Pi scarcity, plants
Wenhao Yue, Xue Xia, Fangying Ge, Kangfeng Cai, Lei Liu, Yong Li, Chengdao Li, Junmei Wang   +7 more
doaj   +1 more source

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis [PDF]

Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Broger, Larissa, Hothorn, Ludwig A, Zhang, Youjun, Lau, Kelvin, Schaaf, Gabriel, Jessen, Henning J, Dutta, Amit K, Hothorn, Michael, Pries, Verena, Harmel, Robert K, Gaugler, Philipp, Puschmann, Robert, Fiedler, Dorothea, Zhu, Jinsheng, Fernie, Alisdair R, Jessen, Henning J., Harmel, Robert K., Dutta, Amit K., Hothorn, Ludwig A.   +18 more
core   +1 more source