The human pathogenic 91del7 mutation in SLC34A1 has no effect in mineral homeostasis in mice
Scientific Reports, 2022 Kidneys are key regulators of phosphate homeostasis. Biallelic mutations of the renal Na+/phosphate cotransporter SLC34A1/NaPi-IIa cause idiopathic infantile hypercalcemia, whereas monoallelic mutations were frequently noted in adults with kidney stones.
Cornelia Bieri +6 more
doaj +1 more source
arXiv, 2023 Homeostasis is a regulatory mechanism that keeps a specific variable close to a set value as other variables fluctuate. The notion of homeostasis can be rigorously formulated when the model of interest is represented as an input-output network, with distinguished input and output nodes, and the dynamics of the network determines the corresponding input-
arxiv
Mechanical loading modulates phosphate related genes in rat bone.
PLoS ONE, 2023 Mechanical loading determines bone mass and bone structure, which involves many biochemical signal molecules. Of these molecules, Mepe and Fgf23 are involved in bone mineralization and phosphate homeostasis.
Ashwini Kumar Nepal +4 more
doaj +2 more sources
Aqueous Contact Ion Pairs of Phosphate Groups with Na$^+$, Ca$^{2+}$ and Mg$^{2+}$ -- Structural Discrimination by Femtosecond Infrared Spectroscopy and Molecular Dynamics Simulations [PDF]
, 2020 The extent of contact and solvent shared ion pairs of phosphate groups with Na$^+$, Ca$^{2+}$ and Mg$^{2+}$ ions in aqueous environment and their relevance for the stability of polyanionic DNA and RNA structures is highly debated. Employing the asymmetric phosphate stretching vibration of dimethyl phosphate (DMP), a model system of the sugar-phosphate ...
arxiv +1 more source
Criticality in Tissue Homeostasis: Models and Experiments [PDF]
J. Stat. Mech. (2020) 013401, 2020 There is considerable theoretical and experimental support to the proposal that tissue homeostasis in the adult skin can be represented as a critical branching process. The homeostatic condition requires that the proliferation rate of the progenitor (P) cells (capable of cell division) is counterbalanced by the loss rate due to the differentiation of a
arxiv +1 more source
Ca2+ efflux facilitated by co-transport of inorganic phosphate anion in the H+/Ca2+ antiporter YfkE
Communications Biology, 2023 Ca2+ is an important signaling messenger. In microorganisms, fungi, and plants, H+/Ca2+ antiporters (CAX) are known to play key roles in the homeostasis of intracellular Ca2+ by catalyzing its efflux across the cell membrane.
Wei Niu +6 more
doaj +1 more source
Protective roles of DMP1 in high phosphate homeostasis. [PDF]
PLoS ONE, 2012 Dmp1 (dentin matrix protein1) null mice (Dmp1(-/-)) display hypophosphatemic rickets with a sharp increase in fibroblast growth factor 23 (FGF23). Disruption of Klotho (the obligatory co-receptor of FGF23) results in hyperphosphatemia with ectopic ...
Afsaneh Rangiani +9 more
doaj +1 more source
Regulation of the Pho Regulon and Reconstruction of the Photosynthetic Apparatus under Phosphate Limitation in Synechocystis sp. PCC 6803 [PDF]
arXiv, 2021 For millennia, cyanobacteria have evolved strategies for acclimatization to dynamic environments- this requires a molecular response system. Phosphate is essential for cellular integrity and metabolism, yet inorganic phosphate is often the limiting nutrient for most aquatic environments.
arxiv
Modification of the zirconia ceramics by different calcium phosphate coatings:comparative study [PDF]
, 2017 The aim of this study was to characterize different calcium phosphate coatings and evaluate in vitro cell response of these materials to ceramics implants. The physical and chemical properties of calcium phosphate coatings formed by RF-magnetron sputtering of calcium phosphate tribasic, hydroxyapatite, calcium phosphate monobasic, calcium phosphate ...
arxiv +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source