Results 1 to 10 of about 30,263 (277)

Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids [PDF]

Journal of Lipid Research
Long-chain acyl-CoA synthetase 1 (ACSL1) catalyzes the conversion of long-chain fatty acids to acyl-CoAs. ACSL1 is required for β-oxidation in tissues that rely on fatty acids as fuel, but no consensus exists on why ACSL1 is induced by inflammatory ...
Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt   +21 more
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Erucic acid utilization by Lactobacillus johnsonii N6.2 [PDF]

Frontiers in Microbiology
A multivariate nutritional analysis indicated that the consumption of erucic acid-rich food, a fatty acid (FA) found primarily in rapeseed and mustard oil, was positively correlated with higher counts of lactic acid bacteria (LAB). Furthermore, we showed
Sharon C. Thompson, Reagan Beliakoff, Timothy J. Garrett, Claudio F. Gonzalez, Graciela L. Lorca   +4 more
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Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV [PDF]

Viruses
PLA2G16 is a member of the phospholipase A2 family that catalyzes the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. Previously, PLA2G16 was found to be a host factor for picornaviruses.
Bingjie Sun, Xiaodong Qin, Taoqing Zhang, Sujie Dong, Yinbo Ye, Changying Wang, Yan Zhang, Rongzeng Hao, Yi Ru, Hong Tian, Haixue Zheng   +10 more
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Optical Control of Phosphatidic Acid Signaling [PDF]

ACS Central Science, 2021
Phosphatidic acids (PAs) are glycerophospholipids that regulate key cell signaling pathways governing cell growth and proliferation, including the mTOR and Hippo pathways. Their acyl chains vary in tail length and degree of saturation, leading to marked differences in the signaling functions of different PA species.
Reika Tei, Johannes Morstein, Andrej Shemet, Dirk Trauner, Jeremy M. Baskin   +4 more
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Phosphatidic acid and neurotransmission [PDF]

Advances in Biological Regulation, 2017
Lipids play a vital role in the health and functioning of neurons and interest in the physiological role of neuronal lipids is certainly increasing. One neuronal function in which neuronal lipids appears to play key roles in neurotransmission. Our understanding of the role of lipids in the synaptic vesicle cycle and neurotransmitter release is becoming
Casey N. Barber, Daniel M. Raben
openaire   +3 more sources

The Role of Osmolytes and Membrane Lipids in the Adaptation of Acidophilic Fungi

Microorganisms, 2023
Acidophiles maintain near-neutral intracellular pH using proton pumps. We have suggested the protective role of osmolytes and membrane lipids in the adaptation to an acidic environment.
Elena A. Ianutsevich, Olga A. Danilova, Olga A. Grum-Grzhimaylo, Vera M. Tereshina   +3 more
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Phosphatidic acid in membrane rearrangements [PDF]

FEBS Letters, 2019
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from −1 to −2 and this change stabilizes protein–lipid interactions.
Zhukovsky Mikhail A, Filograna Angela, Luini Alberto, Corda Daniela, Valente Carmen   +4 more
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New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein [PDF]

International Journal of Molecular Sciences, 2020
Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of physiological and pathological events, including immune responses, neuronal networking, bipolar disorder, obsessive-compulsive disorder, fragile X syndrome, cancer, and type 2 ...
Fumio Sakane, Fumi Hoshino, Chiaki Murakami   +2 more
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Enhanced Adaptability to Limited Water Supply Regulated by Diethyl Aminoethyl Hexanoate (DA-6) Associated With Lipidomic Reprogramming in Two White Clover Genotypes

Frontiers in Plant Science, 2022
Membrane lipid reprogramming is one of the most important adaptive strategies in plant species under unfavorable environmental circumstances. Therefore, the present experiment was conducted to elucidate the effect of diethyl aminoethyl hexanoate (DA-6 ...
Muhammad Jawad Hassan, Hongyin Qi, Bizhen Cheng, Shafiq Hussain, Yan Peng, Wei Liu, Guangyan Feng, Junming Zhao, Zhou Li   +8 more
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Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

Nature Communications, 2021
Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis ...
Sheena Dass, Serena Shunmugam, Laurence Berry, Christophe-Sebastien Arnold, Nicholas J. Katris, Samuel Duley, Fabien Pierrel, Marie-France Cesbron-Delauw, Yoshiki Yamaryo-Botté, Cyrille Y. Botté   +9 more
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