Results 1 to 10 of about 5,016,109 (334)
Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate. [PDF]
Org Biomol Chem, 2022 With a CoIII(salen)OTs catalyst, dibenzyl phosphate ring-opens a variety of terminal epoxides with excellent regio-selectively and yields up to 85%.
Andringa RLH, Jonker M, Minnaard AJ.
europepmc +2 more sources
Optical Control of Phosphatidic Acid Signaling [PDF]
ACS Central Science, 2021 Phosphatidic acids (PAs) are glycerophospholipids that regulate key cell signaling pathways governing cell growth and proliferation, including the mTOR and Hippo pathways. Their acyl chains vary in tail length and degree of saturation, leading to marked differences in the signaling functions of different PA species.
Reika Tei +4 more
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Phosphatidic acid and neurotransmission [PDF]
Advances in Biological Regulation, 2017 Lipids play a vital role in the health and functioning of neurons and interest in the physiological role of neuronal lipids is certainly increasing. One neuronal function in which neuronal lipids appears to play key roles in neurotransmission. Our understanding of the role of lipids in the synaptic vesicle cycle and neurotransmitter release is becoming
Casey N. Barber, Daniel M. Raben
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Phosphatidic acid in membrane rearrangements [PDF]
FEBS Letters, 2019 Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from −1 to −2 and this change stabilizes protein–lipid interactions.
Zhukovsky Mikhail A +4 more
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New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein [PDF]
International Journal of Molecular Sciences, 2020 Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of physiological and pathological events, including immune responses, neuronal networking, bipolar disorder, obsessive-compulsive disorder, fragile X syndrome, cancer, and type 2 ...
Fumio Sakane +2 more
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Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Mitochondria: Signaling with phosphatidic acid [PDF]
The International Journal of Biochemistry & Cell Biology, 2012 Mitochondria, once viewed as functioning relatively autonomously in the cell, have increasingly been recognized to be involved in numerous signaling networks that impact on a wide range of cell biological processes. In addition to the many types of proteins that mediate these pathways, the importance of signaling functions regulated via lipids and ...
Chia-Ying Yang, Michael A. Frohman
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Phosphatidic acid synthesis in bacteria [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013 Membrane phospholipid synthesis is a vital facet of bacterial physiology. Although the spectrum of phospholipid headgroup structures produced by bacteria is large, the key precursor to all of these molecules is phosphatidic acid (PtdOH). Glycerol-3-phosphate derived from the glycolysis via glycerol-phosphate synthase is the universal source for the ...
Jiangwei Yao, Charles O. Rock
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Mass Spectrometry Reviews, EarlyView., 2023 Abstract Analysis of triacylglycerol (TG) and phospholipid sn‐positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods.
Mikael Fabritius, Baoru Yang
wiley +1 more source
PHOSPHATIDIC ACID SYNTHESIS IN YEAST [PDF]
Biochemical Journal, 1965 1. The presence of palmitoyl-CoA-l-glycerol 1-phosphate palmitoyltransferase (EC2.3.1.15) has been demonstrated in a particulate fraction of baker's yeast. 2. The enzyme has been characterized, and its activity studied as a function of pH and concentration of substrates. 3. Inhibition by thiol poisons and protection by acyl-CoA have been used to obtain
F. Lynen, N. J. Kuhn
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