Results 221 to 230 of about 19,316 (249)

Regulation of mTOR by phosphatidic acid

Trends in Endocrinology & Metabolism, 2023
mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural findings and propose a model for PA activation of mTORC1.
Maria A. Frias, Ahmet Hatipoglu, David A. Foster   +2 more
openaire   +2 more sources

Messenger functions of phosphatidic acid

Chemistry and Physics of Lipids, 1996
Under physiological conditions, phosphatidic acid (PA) is an anionic phospholipid with moderate biological reactivity. Some of its biological effects can be attributed to lyso-PA and diacylglycerol generated by the action of cellular hydrolases. However, it is clear that the parent compound exhibits biological activities of its own.
D, English, Y, Cui, R A, Siddiqui
openaire   +2 more sources

Signaling functions of phosphatidic acid

Progress in Lipid Research, 2006
Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse cellular functions in plants, animals, and microorganisms. Considerable progress has been made recently on the production, cellular function, and mode of action of PA in the cell.
Xuemin, Wang, Shivakumar Pattada, Devaiah, Wenhua, Zhang, Ruth, Welti   +3 more
openaire   +2 more sources

Phosphatidic Acid-Mediated Signaling

2013
Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several enzymatic reactions, including different phospholipases, lipid kinases, and phosphatases. PA interacts with various proteins and the interactions may modulate enzyme catalytic activities and/or ...
Yu, Liu, Yuan, Su, Xuemin, Wang
openaire   +2 more sources

Phosphatidic acids and derivatives VI: Phosphatidic acids derived from batyl alcohol

Recueil des Travaux Chimiques des Pays-Bas, 1956
AbstractThe synthesis of a number of phosphatidic acids derived from batyl alcohol and of the two batyl alcohol phosphoric acids is described.Some properties of these substances are discussed.
L. J. Stegerhoek, P. E. Verkade
openaire   +1 more source

Phosphatide acids and derivatives. VIII). Synthesis of monobenzyl esters of phosphatidic acids

Recueil des Travaux Chimiques des Pays-Bas, 1958
AbstractThe preparation of dibenzyl esters of phosphatidic acids and their mono‐debenzylation by boiling with anhydrous sodium iodide in acetone solution is described.
J. W. Gielkens, M. A. Hoefnagel, L. J. Stegerhoek, P. E. Verkade   +3 more
openaire   +1 more source

Thyroid al Synthesis of Phosphatidic Acid

Endocrinology, 1968
The enzymatic formation of phosphatidic acid from l-α-glycerophosphate and fatty acid was studied in cell free systems of calf and guinea pig thyroid. Phosphatidic acid formation was assayed by measuring the conversion of water-soluble l-α-glycerophosphate to the lipid which is extractable by organic solvents.
openaire   +2 more sources

Phosphatidic acids as intermediates in fatty acid absorption

Archives of Biochemistry and Biophysics, 1960
Abstract Following the incubation of intestinal segments from the hamster in either palmitic acid-C 14 or NaH 2 P 32 O 4 , the phospholipid fraction containing the major activity is phosphatidic acids. The incorporation of P 32 into phosphatidic acids in the intestinal wall is increased two- to threefold when fatty acids are included in the ...
J M, JOHNSTON, J H, BEARDEN
openaire   +2 more sources

Genetically Encoded Probes for Phosphatidic Acid

2012
In addition to forming bilayers to separate cellular compartments, lipids participate in vesicular trafficking and signal transduction. Among others, phosphatidic acid (PA) is emerging as an important signaling molecule. The spatiotemporal distribution of cellular PA appears to be tightly regulated by localized synthesis and a rapid metabolism ...
Kassas, Nawal, Tryoen, Petra, Corrotte, Matthias, Thahouly, Tamou, Bader, Marie-France, Grant, Nancy, Vitale, Nicolas   +6 more
openaire   +3 more sources

Phosphatidic acid- and phosphatidylserine-binding proteins

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids with well-recognized structural roles in cellular membranes. They are also signaling lipids since their regulated formation (or appearance) can constitute an important signal for downstream responses.
Catherine L, Stace, Nicholas T, Ktistakis   +1 more
openaire   +2 more sources