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Regulation of mTOR by phosphatidic acid
Trends in Endocrinology & Metabolism, 2023mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural findings and propose a model for PA activation of mTORC1.
Maria A. Frias +2 more
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Messenger functions of phosphatidic acid
Chemistry and Physics of Lipids, 1996Under physiological conditions, phosphatidic acid (PA) is an anionic phospholipid with moderate biological reactivity. Some of its biological effects can be attributed to lyso-PA and diacylglycerol generated by the action of cellular hydrolases. However, it is clear that the parent compound exhibits biological activities of its own.
Rafat A. Siddiqui +5 more
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Signaling functions of phosphatidic acid
Progress in Lipid Research, 2006Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse cellular functions in plants, animals, and microorganisms. Considerable progress has been made recently on the production, cellular function, and mode of action of PA in the cell.
Xuemin Wang +5 more
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Phosphatidic Acid-Mediated Signaling
2013Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several enzymatic reactions, including different phospholipases, lipid kinases, and phosphatases. PA interacts with various proteins and the interactions may modulate enzyme catalytic activities and/or ...
Yuan Su, Xuemin Wang, Yu Liu
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
1. The membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activity of rat lung has been investigated in cytosol and microsomal fractions using as a substrate [32P]phosphatidate bound to heat inactivated rat liver microsomes. Both activities demonstrated broad pH optima with a maximum of 7.4--8 for the cytosol and a maximum of 6.5--7.5
Paul G. Casola, Fred Possmayer
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1. The membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activity of rat lung has been investigated in cytosol and microsomal fractions using as a substrate [32P]phosphatidate bound to heat inactivated rat liver microsomes. Both activities demonstrated broad pH optima with a maximum of 7.4--8 for the cytosol and a maximum of 6.5--7.5
Paul G. Casola, Fred Possmayer
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Phosphatidic acids and derivatives VI: Phosphatidic acids derived from batyl alcohol [PDF]
Recueil des Travaux Chimiques des Pays-Bas, 1956 AbstractThe synthesis of a number of phosphatidic acids derived from batyl alcohol and of the two batyl alcohol phosphoric acids is described.Some properties of these substances are discussed.
P. E. Verkade, L. J. Stegerhoek
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Phosphatide acids and derivatives. VIII). Synthesis of monobenzyl esters of phosphatidic acids
Recueil des Travaux Chimiques des Pays-Bas, 1958AbstractThe preparation of dibenzyl esters of phosphatidic acids and their mono‐debenzylation by boiling with anhydrous sodium iodide in acetone solution is described.
P. E. Verkade +3 more
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Phosphatidic acids as intermediates in fatty acid absorption
Archives of Biochemistry and Biophysics, 1960Abstract Following the incubation of intestinal segments from the hamster in either palmitic acid-C 14 or NaH 2 P 32 O 4 , the phospholipid fraction containing the major activity is phosphatidic acids. The incorporation of P 32 into phosphatidic acids in the intestinal wall is increased two- to threefold when fatty acids are included in the ...
John M. Johnston, James H. Bearden
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