Results 241 to 250 of about 30,263 (277)

VLDL lipidomics reveals hepatocellular lipidome changes in metabolic dysfunction-associated steatotic liver disease. [PDF]

open access: yesHepatol Commun
Guardamino Ojeda D   +10 more
europepmc   +1 more source

Unexpected contribution of the Fak system and the thioesterase TesE to the growth and membrane physiology of <i>Enterococcus faecalis</i>. [PDF]

open access: yesJ Bacteriol
Johnston RD   +8 more
europepmc   +1 more source

Regulation of mTOR by phosphatidic acid

Trends in Endocrinology & Metabolism, 2023
mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural findings and propose a model for PA activation of mTORC1.
Maria A. Frias   +2 more
openaire   +2 more sources

Signaling functions of phosphatidic acid

Progress in Lipid Research, 2006
Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse cellular functions in plants, animals, and microorganisms. Considerable progress has been made recently on the production, cellular function, and mode of action of PA in the cell.
Xuemin Wang   +5 more
openaire   +3 more sources

Messenger functions of phosphatidic acid

Chemistry and Physics of Lipids, 1996
Under physiological conditions, phosphatidic acid (PA) is an anionic phospholipid with moderate biological reactivity. Some of its biological effects can be attributed to lyso-PA and diacylglycerol generated by the action of cellular hydrolases. However, it is clear that the parent compound exhibits biological activities of its own.
Rafat A. Siddiqui   +5 more
openaire   +3 more sources

Phosphatidic Acid-Mediated Signaling

2013
Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several enzymatic reactions, including different phospholipases, lipid kinases, and phosphatases. PA interacts with various proteins and the interactions may modulate enzyme catalytic activities and/or ...
Yuan Su, Xuemin Wang, Yu Liu
openaire   +3 more sources

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