Results 251 to 260 of about 20,811 (292)
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Regulation of mTOR by phosphatidic acid
Trends in Endocrinology & Metabolism, 2023mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural findings and propose a model for PA activation of mTORC1.
Maria A. Frias +2 more
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Signaling functions of phosphatidic acid
Progress in Lipid Research, 2006Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse cellular functions in plants, animals, and microorganisms. Considerable progress has been made recently on the production, cellular function, and mode of action of PA in the cell.
Xuemin, Wang +3 more
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Messenger functions of phosphatidic acid
Chemistry and Physics of Lipids, 1996Under physiological conditions, phosphatidic acid (PA) is an anionic phospholipid with moderate biological reactivity. Some of its biological effects can be attributed to lyso-PA and diacylglycerol generated by the action of cellular hydrolases. However, it is clear that the parent compound exhibits biological activities of its own.
D, English, Y, Cui, R A, Siddiqui
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
1. The membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activity of rat lung has been investigated in cytosol and microsomal fractions using as a substrate [32P]phosphatidate bound to heat inactivated rat liver microsomes. Both activities demonstrated broad pH optima with a maximum of 7.4--8 for the cytosol and a maximum of 6.5--7.5
P G, Casola, F, Possmayer
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1. The membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activity of rat lung has been investigated in cytosol and microsomal fractions using as a substrate [32P]phosphatidate bound to heat inactivated rat liver microsomes. Both activities demonstrated broad pH optima with a maximum of 7.4--8 for the cytosol and a maximum of 6.5--7.5
P G, Casola, F, Possmayer
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Phosphatidic Acid-Mediated Signaling
2013Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several enzymatic reactions, including different phospholipases, lipid kinases, and phosphatases. PA interacts with various proteins and the interactions may modulate enzyme catalytic activities and/or ...
Yu, Liu, Yuan, Su, Xuemin, Wang
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Phosphatidic acid phosphatase in the erythrocyte membrane
Biochimica et Biophysica Acta, 1963A magnesium-dependent α-phosphatidic acid phosphatase is present in the erythrocyte membrane which is stimulated by sodium, and to a lesser extent by lithium, ammonium, potassium and rubidium. Cesium produces little or no stimulation. No magnesium-dependent, sodium-stimulated, activity was observed with β-phosphatidic acid or lysophosphatidic acid; but
L E, HOKIN, M R, HOKIN, D, MATHISON
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Evidence for Phosphatidic Acid as the Sodium Carrier
Nature, 1959THE mechanism of active transport of ions is one of the basic problems of cell physiology. For example, most cells extrude sodium against a concentration gradient, and the system which brings this about has been termed the ‘sodium pump’. The biochemical mechanism of the ‘sodium pump’ has remained a mystery.
L E, HOKIN, M R, HOKIN
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Phosphatidic acid- and phosphatidylserine-binding proteins
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids with well-recognized structural roles in cellular membranes. They are also signaling lipids since their regulated formation (or appearance) can constitute an important signal for downstream responses.
Catherine L, Stace +1 more
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Thyroid al Synthesis of Phosphatidic Acid
Endocrinology, 1968The enzymatic formation of phosphatidic acid from l-α-glycerophosphate and fatty acid was studied in cell free systems of calf and guinea pig thyroid. Phosphatidic acid formation was assayed by measuring the conversion of water-soluble l-α-glycerophosphate to the lipid which is extractable by organic solvents.
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Genetically Encoded Probes for Phosphatidic Acid
2012In addition to forming bilayers to separate cellular compartments, lipids participate in vesicular trafficking and signal transduction. Among others, phosphatidic acid (PA) is emerging as an important signaling molecule. The spatiotemporal distribution of cellular PA appears to be tightly regulated by localized synthesis and a rapid metabolism ...
Kassas, Nawal +6 more
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